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Design, synthesis and Photodynamic antimicrobial activity of ruthenium trischelate diimine complexes

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Published
  • R. F. Donnelly
  • N. C. Fletcher
  • P. J. McCague
  • J. Donnelly
  • P. A. McCarron
  • M. M. Tunney
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<mark>Journal publication date</mark>30/04/2007
<mark>Journal</mark>Letters in Drug Design and Discovery
Issue number3
Volume4
Number of pages5
Pages (from-to)175-179
Publication StatusPublished
<mark>Original language</mark>English

Abstract

In this study, we describe, for the first time, the synthesis and photophysical and microbiological investigation of ruthenium trischelate diimine complexes designed so as to possess properties specifically suited for use in Photodynamic antimicrobial chemotherapy (PACT). Of the three compounds investigated, one ([Ru(dmob)3]Cl2) has demonstrated considerable promise as a photosensitiser for use in PACT. As a result, this compound is now the subject of comprehensive chemical, toxicological and formulation studies.