Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Design, synthesis and Photodynamic antimicrobial activity of ruthenium trischelate diimine complexes
AU - Donnelly, R. F.
AU - Fletcher, N. C.
AU - McCague, P. J.
AU - Donnelly, J.
AU - McCarron, P. A.
AU - Tunney, M. M.
PY - 2007/4/30
Y1 - 2007/4/30
N2 - In this study, we describe, for the first time, the synthesis and photophysical and microbiological investigation of ruthenium trischelate diimine complexes designed so as to possess properties specifically suited for use in Photodynamic antimicrobial chemotherapy (PACT). Of the three compounds investigated, one ([Ru(dmob)3]Cl2) has demonstrated considerable promise as a photosensitiser for use in PACT. As a result, this compound is now the subject of comprehensive chemical, toxicological and formulation studies.
AB - In this study, we describe, for the first time, the synthesis and photophysical and microbiological investigation of ruthenium trischelate diimine complexes designed so as to possess properties specifically suited for use in Photodynamic antimicrobial chemotherapy (PACT). Of the three compounds investigated, one ([Ru(dmob)3]Cl2) has demonstrated considerable promise as a photosensitiser for use in PACT. As a result, this compound is now the subject of comprehensive chemical, toxicological and formulation studies.
KW - Photodynamic antimicrobial chemotherapy
KW - Ruthenium
U2 - 10.2174/157018007780077390
DO - 10.2174/157018007780077390
M3 - Journal article
AN - SCOPUS:33947545074
VL - 4
SP - 175
EP - 179
JO - Letters in Drug Design and Discovery
JF - Letters in Drug Design and Discovery
SN - 1570-1808
IS - 3
ER -