Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Development of a proteolytically stable retro-inverso peptide inhibitor of β-amyloid oligomerization as a potential novel treatment for Alzheimer's disease
AU - Taylor, Mark
AU - Moore, Susan
AU - Mayes, Jennifer
AU - Parkin, Edward
AU - Beeg, Marten
AU - Canovi, Mara
AU - Gobbi, Marco
AU - Mann, David M A
AU - Allsop, David
PY - 2010
Y1 - 2010
N2 - The formation of beta-amyloid (Abeta) deposits in the brain is likely to be a seminal step in the development of Alzheimer's disease. Recent studies support the hypothesis that Abeta soluble oligomers are toxic to cells and have potent effects on memory and learning. Inhibiting the early stages of Abeta aggregation could, therefore, provide a novel approach to treating the underlying cause of AD. We have designed a retro-inverso peptide (RI-OR2, H(2)N-r
AB - The formation of beta-amyloid (Abeta) deposits in the brain is likely to be a seminal step in the development of Alzheimer's disease. Recent studies support the hypothesis that Abeta soluble oligomers are toxic to cells and have potent effects on memory and learning. Inhibiting the early stages of Abeta aggregation could, therefore, provide a novel approach to treating the underlying cause of AD. We have designed a retro-inverso peptide (RI-OR2, H(2)N-r
KW - Alzheimer Disease
KW - Amino Acid Sequence
KW - Amyloid beta-Peptides
KW - Animals
KW - Cell Aggregation
KW - Cell Line
KW - Cell Survival
KW - Humans
KW - Immunoassay
KW - Molecular Sequence Data
KW - Peptide Fragments
KW - Peptides
KW - Surface Plasmon Resonance
KW - Thiazoles
U2 - 10.1021/bi100144m
DO - 10.1021/bi100144m
M3 - Journal article
C2 - 20230062
VL - 49
SP - 3261
EP - 3272
JO - Biochemistry
JF - Biochemistry
SN - 1520-4995
IS - 15
ER -