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Development of guidelines to reduce, handle and report missing data in palliative care trials: A multi-stakeholder modified nominal group technique

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Development of guidelines to reduce, handle and report missing data in palliative care trials: A multi-stakeholder modified nominal group technique. / Hussain, Jamilla A; White, Ian R; Johnson, Miriam J et al.
In: Palliative Medicine, Vol. 36, No. 1, 17.01.2022, p. 59-70.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Hussain, JA, White, IR, Johnson, MJ, Byrne, A, Preston, NJ, Haines, A, Seddon, K & Peters, TJ 2022, 'Development of guidelines to reduce, handle and report missing data in palliative care trials: A multi-stakeholder modified nominal group technique', Palliative Medicine, vol. 36, no. 1, pp. 59-70. https://doi.org/10.1177/02692163211065597

APA

Hussain, J. A., White, I. R., Johnson, M. J., Byrne, A., Preston, N. J., Haines, A., Seddon, K., & Peters, T. J. (2022). Development of guidelines to reduce, handle and report missing data in palliative care trials: A multi-stakeholder modified nominal group technique. Palliative Medicine, 36(1), 59-70. https://doi.org/10.1177/02692163211065597

Vancouver

Hussain JA, White IR, Johnson MJ, Byrne A, Preston NJ, Haines A et al. Development of guidelines to reduce, handle and report missing data in palliative care trials: A multi-stakeholder modified nominal group technique. Palliative Medicine. 2022 Jan 17;36(1):59-70. Epub 2022 Jan 17. doi: 10.1177/02692163211065597

Author

Hussain, Jamilla A ; White, Ian R ; Johnson, Miriam J et al. / Development of guidelines to reduce, handle and report missing data in palliative care trials : A multi-stakeholder modified nominal group technique. In: Palliative Medicine. 2022 ; Vol. 36, No. 1. pp. 59-70.

Bibtex

@article{b9d6687d97ef47508360a54498161a00,
title = "Development of guidelines to reduce, handle and report missing data in palliative care trials: A multi-stakeholder modified nominal group technique",
abstract = "Background:: Missing data can introduce bias and reduce the power, precision and generalisability of study findings. Guidelines on how to address missing data are limited in scope and detail, and poorly implemented. Aim:: To develop guidelines on how best to (i) reduce, (ii) handle and (iii) report missing data in palliative care clinical trials. Design:: Modified nominal group technique. Setting/participants:: Patient and public research partners, palliative care clinicians, trialists, methodologists and statisticians attended a 1-day workshop, following which a multi-stakeholder development group drafted the guidelines. Results:: Seven main recommendations for reducing missing data, nine for handling missing data and twelve for reporting missing data were developed. The top five recommendations were: (i) train all research staff on missing data, (ii) prepare for missing data at the trial design stage, (iii) address missing data in the statistical analysis plan, (iv) collect the reasons for missing data and (v) report descriptive statistics comparing the baseline characteristics of those with missing and observed data. Reducing missing data, preparing for missing data and understanding the reasons for missing data were greater priorities for stakeholders than how to deal with missing data once they had occurred. Conclusion:: Comprehensive guidelines on how to address missing data were developed by stakeholders involved in palliative care trials. Implementation of the guidelines will require endorsement of research funders and research journals.",
keywords = "Original Articles, Missing data, lost to follow up, randomised controlled trials, palliative care, palliative medicine, guideline",
author = "Hussain, {Jamilla A} and White, {Ian R} and Johnson, {Miriam J} and Anthony Byrne and Preston, {Nancy J} and Andy Haines and Kathy Seddon and Peters, {Tim J}",
year = "2022",
month = jan,
day = "17",
doi = "10.1177/02692163211065597",
language = "English",
volume = "36",
pages = "59--70",
journal = "Palliative Medicine",
issn = "0269-2163",
publisher = "SAGE Publications Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Development of guidelines to reduce, handle and report missing data in palliative care trials

T2 - A multi-stakeholder modified nominal group technique

AU - Hussain, Jamilla A

AU - White, Ian R

AU - Johnson, Miriam J

AU - Byrne, Anthony

AU - Preston, Nancy J

AU - Haines, Andy

AU - Seddon, Kathy

AU - Peters, Tim J

PY - 2022/1/17

Y1 - 2022/1/17

N2 - Background:: Missing data can introduce bias and reduce the power, precision and generalisability of study findings. Guidelines on how to address missing data are limited in scope and detail, and poorly implemented. Aim:: To develop guidelines on how best to (i) reduce, (ii) handle and (iii) report missing data in palliative care clinical trials. Design:: Modified nominal group technique. Setting/participants:: Patient and public research partners, palliative care clinicians, trialists, methodologists and statisticians attended a 1-day workshop, following which a multi-stakeholder development group drafted the guidelines. Results:: Seven main recommendations for reducing missing data, nine for handling missing data and twelve for reporting missing data were developed. The top five recommendations were: (i) train all research staff on missing data, (ii) prepare for missing data at the trial design stage, (iii) address missing data in the statistical analysis plan, (iv) collect the reasons for missing data and (v) report descriptive statistics comparing the baseline characteristics of those with missing and observed data. Reducing missing data, preparing for missing data and understanding the reasons for missing data were greater priorities for stakeholders than how to deal with missing data once they had occurred. Conclusion:: Comprehensive guidelines on how to address missing data were developed by stakeholders involved in palliative care trials. Implementation of the guidelines will require endorsement of research funders and research journals.

AB - Background:: Missing data can introduce bias and reduce the power, precision and generalisability of study findings. Guidelines on how to address missing data are limited in scope and detail, and poorly implemented. Aim:: To develop guidelines on how best to (i) reduce, (ii) handle and (iii) report missing data in palliative care clinical trials. Design:: Modified nominal group technique. Setting/participants:: Patient and public research partners, palliative care clinicians, trialists, methodologists and statisticians attended a 1-day workshop, following which a multi-stakeholder development group drafted the guidelines. Results:: Seven main recommendations for reducing missing data, nine for handling missing data and twelve for reporting missing data were developed. The top five recommendations were: (i) train all research staff on missing data, (ii) prepare for missing data at the trial design stage, (iii) address missing data in the statistical analysis plan, (iv) collect the reasons for missing data and (v) report descriptive statistics comparing the baseline characteristics of those with missing and observed data. Reducing missing data, preparing for missing data and understanding the reasons for missing data were greater priorities for stakeholders than how to deal with missing data once they had occurred. Conclusion:: Comprehensive guidelines on how to address missing data were developed by stakeholders involved in palliative care trials. Implementation of the guidelines will require endorsement of research funders and research journals.

KW - Original Articles

KW - Missing data

KW - lost to follow up

KW - randomised controlled trials

KW - palliative care

KW - palliative medicine

KW - guideline

U2 - 10.1177/02692163211065597

DO - 10.1177/02692163211065597

M3 - Journal article

VL - 36

SP - 59

EP - 70

JO - Palliative Medicine

JF - Palliative Medicine

SN - 0269-2163

IS - 1

ER -