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Development of K-doped ZnO nanoparticles encapsulated crosslinked chitosan based new membranes to stimulate angiogenesis in tissue engineered skin grafts

Research output: Contribution to Journal/MagazineJournal articlepeer-review

  • Lubna Shahzadi
  • Aqif Anwar Chaudhry
  • Abdur Raheem Aleem
  • Muhammad Hamza Malik
  • Kashif Ijaz
  • Hafsah Akhtar
  • Farah Alvi
  • Ather Farooq Khan
  • Ihtesham Ur Rehman
  • Muhammad Yar
<mark>Journal publication date</mark>1/12/2018
<mark>Journal</mark>International Journal of Biological Macromolecules
Number of pages8
Pages (from-to)721-728
Publication StatusPublished
Early online date24/08/18
<mark>Original language</mark>English


Nanoparticles are well recognized for their biological applications including tissue-regeneration due to large surface area and chemical properties. In this study, K-doped zinc oxide (ZnO) nanoparticles containing porous hydrogels were synthesized via freeze gelation. The morphology and pore dimensions were studied by scanning electron microscopy (SEM). The chemical structural analysis of the synthesized hydrogels was investigated by Fourier Transform Infrared (FTIR) spectroscopy. In swelling studies, material containing ZnO nanoparticles with 2% potassium dopant concentration CLH-K2.0) showed greater degree of swelling as compared to all other materials. The degradation studied was tested in three different degradation media, i.e. phosphate buffer saline (PBS), lysozyme and hydrogen peroxide and relatively higher degradation was seen in hydrogen peroxide. The synthesized hydrogels were implanted on the chick chorioallantoic membrane (CAM) to investigate their angiogenic potential. The CLH-K2.0 hydrogel stimulated angiogenesis greater than all other materials; blood vessels were attached and grown inside this scaffold, showing its strong angiogenic potential.