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Development of Large-Scale Functional Networks over the Lifespan

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Development of Large-Scale Functional Networks over the Lifespan. / Schlee, Winfried; Leirer, Vera Maria; Kolassa, Stephan et al.
In: Neurobiology of Aging, Vol. 33, No. 10, 01.10.2012, p. 2411-2421.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Schlee, W, Leirer, VM, Kolassa, S, Thurm, F, Elbert, T & Kolassa, IT 2012, 'Development of Large-Scale Functional Networks over the Lifespan', Neurobiology of Aging, vol. 33, no. 10, pp. 2411-2421. https://doi.org/10.1016/j.neurobiolaging.2011.11.031

APA

Schlee, W., Leirer, V. M., Kolassa, S., Thurm, F., Elbert, T., & Kolassa, I. T. (2012). Development of Large-Scale Functional Networks over the Lifespan. Neurobiology of Aging, 33(10), 2411-2421. https://doi.org/10.1016/j.neurobiolaging.2011.11.031

Vancouver

Schlee W, Leirer VM, Kolassa S, Thurm F, Elbert T, Kolassa IT. Development of Large-Scale Functional Networks over the Lifespan. Neurobiology of Aging. 2012 Oct 1;33(10):2411-2421. Epub 2012 Jan 10. doi: 10.1016/j.neurobiolaging.2011.11.031

Author

Schlee, Winfried ; Leirer, Vera Maria ; Kolassa, Stephan et al. / Development of Large-Scale Functional Networks over the Lifespan. In: Neurobiology of Aging. 2012 ; Vol. 33, No. 10. pp. 2411-2421.

Bibtex

@article{1b77675877e148dab0687911eac607ec,
title = "Development of Large-Scale Functional Networks over the Lifespan",
abstract = "The development of large-scale functional organization of the human brain across the lifespan is not well understood. Here we used magnetoencephalographic recordings of 53 adults (ages 18–89) to characterize functional brain networks in the resting state. Slow frequencies engage larger networks than higher frequencies and show different development over the lifespan. Networks in the delta (2–4 Hz) frequency range decrease, while networks in the beta/gamma frequency range (> 16 Hz) increase in size with advancing age. Results show that the right frontal lobe and the temporal areas in both hemispheres are important relay stations in the expanding high-frequency networks. Neuropsychological tests confirmed the tendency of cognitive decline with older age. The decrease in visual memory and visuoconstructive functions was strongly associated with the age-dependent enhancement of functional connectivity in both temporal lobes. Using functional network analysis this study elucidates important neuronal principles underlying age-related cognitive decline paving mental deterioration in senescence.",
keywords = "Functional networks, Lifespan, MEG, Cognitive decline",
author = "Winfried Schlee and Leirer, {Vera Maria} and Stephan Kolassa and Franka Thurm and Thomas Elbert and Kolassa, {Iris- Tatjana}",
year = "2012",
month = oct,
day = "1",
doi = "10.1016/j.neurobiolaging.2011.11.031",
language = "English",
volume = "33",
pages = "2411--2421",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "10",

}

RIS

TY - JOUR

T1 - Development of Large-Scale Functional Networks over the Lifespan

AU - Schlee, Winfried

AU - Leirer, Vera Maria

AU - Kolassa, Stephan

AU - Thurm, Franka

AU - Elbert, Thomas

AU - Kolassa, Iris- Tatjana

PY - 2012/10/1

Y1 - 2012/10/1

N2 - The development of large-scale functional organization of the human brain across the lifespan is not well understood. Here we used magnetoencephalographic recordings of 53 adults (ages 18–89) to characterize functional brain networks in the resting state. Slow frequencies engage larger networks than higher frequencies and show different development over the lifespan. Networks in the delta (2–4 Hz) frequency range decrease, while networks in the beta/gamma frequency range (> 16 Hz) increase in size with advancing age. Results show that the right frontal lobe and the temporal areas in both hemispheres are important relay stations in the expanding high-frequency networks. Neuropsychological tests confirmed the tendency of cognitive decline with older age. The decrease in visual memory and visuoconstructive functions was strongly associated with the age-dependent enhancement of functional connectivity in both temporal lobes. Using functional network analysis this study elucidates important neuronal principles underlying age-related cognitive decline paving mental deterioration in senescence.

AB - The development of large-scale functional organization of the human brain across the lifespan is not well understood. Here we used magnetoencephalographic recordings of 53 adults (ages 18–89) to characterize functional brain networks in the resting state. Slow frequencies engage larger networks than higher frequencies and show different development over the lifespan. Networks in the delta (2–4 Hz) frequency range decrease, while networks in the beta/gamma frequency range (> 16 Hz) increase in size with advancing age. Results show that the right frontal lobe and the temporal areas in both hemispheres are important relay stations in the expanding high-frequency networks. Neuropsychological tests confirmed the tendency of cognitive decline with older age. The decrease in visual memory and visuoconstructive functions was strongly associated with the age-dependent enhancement of functional connectivity in both temporal lobes. Using functional network analysis this study elucidates important neuronal principles underlying age-related cognitive decline paving mental deterioration in senescence.

KW - Functional networks

KW - Lifespan

KW - MEG

KW - Cognitive decline

U2 - 10.1016/j.neurobiolaging.2011.11.031

DO - 10.1016/j.neurobiolaging.2011.11.031

M3 - Journal article

VL - 33

SP - 2411

EP - 2421

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 10

ER -