Accepted author manuscript, 355 KB, PDF document
Available under license: CC BY: Creative Commons Attribution 4.0 International License
Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Dexterity and Bimanual Coordination, Cognitive Function, and Mental and Cognitive Well-Being in People with Young Onset Dementia
T2 - A Case-Control Study
AU - Berry, Ethan C J
AU - Sanal-Hayes, Nilihan E M
AU - Sculthorpe, Nicholas F
AU - Munishankar, Sowmya
AU - Tolson, Debbie
AU - Hayes, Lawrence D
PY - 2025/5/21
Y1 - 2025/5/21
N2 - BACKGROUND: Dexterity and bimanual coordination, cognitive function, and mental and cognitive well-being have not been previously examined in people with young onset dementia. Therefore, this study examined dexterity and bimanual coordination, cognitive function, and mental and cognitive well-being in people with young onset dementia (n = 16), and age-matched healthy controls (n = 17).METHODS: Both groups completed the Purdue Pegboard Test (dexterity and bimanual coordination), Addenbrooke's Cognitive Examination III (cognitive function), General Anxiety Disorder-7 (general anxiety), Generic health-related quality of life measures (overall health), General Self-Efficacy Scale (self-efficacy), Patient Health Questionnaire (depression), and The Pittsburgh Sleep Quality Index (sleep quality).RESULTS: The main findings of the present investigation were that people with young onset dementia displayed poorer dexterity and bimanual coordination, generic health-related quality of life analogue, and generic self-efficacy compared with age-matched healthy controls. However, people with young onset dementia and age-matched healthy controls were comparable for anxiety, depression, generic health-related quality of life index, and sleep quality index.CONCLUSIONS: This study highlights differences in dexterity and bimanual coordination, quality of life, and self-efficacy between people with young onset dementia and controls. People with young onset dementia exhibited poorer dexterity, generic health-related quality of life analogue, and self-efficacy. The study highlights the potential impacts of young onset dementia on dexterity, health-related quality of life, and self-efficacy. More longitudinal research is needed to assess the time course of this impact and explore support strategies.
AB - BACKGROUND: Dexterity and bimanual coordination, cognitive function, and mental and cognitive well-being have not been previously examined in people with young onset dementia. Therefore, this study examined dexterity and bimanual coordination, cognitive function, and mental and cognitive well-being in people with young onset dementia (n = 16), and age-matched healthy controls (n = 17).METHODS: Both groups completed the Purdue Pegboard Test (dexterity and bimanual coordination), Addenbrooke's Cognitive Examination III (cognitive function), General Anxiety Disorder-7 (general anxiety), Generic health-related quality of life measures (overall health), General Self-Efficacy Scale (self-efficacy), Patient Health Questionnaire (depression), and The Pittsburgh Sleep Quality Index (sleep quality).RESULTS: The main findings of the present investigation were that people with young onset dementia displayed poorer dexterity and bimanual coordination, generic health-related quality of life analogue, and generic self-efficacy compared with age-matched healthy controls. However, people with young onset dementia and age-matched healthy controls were comparable for anxiety, depression, generic health-related quality of life index, and sleep quality index.CONCLUSIONS: This study highlights differences in dexterity and bimanual coordination, quality of life, and self-efficacy between people with young onset dementia and controls. People with young onset dementia exhibited poorer dexterity, generic health-related quality of life analogue, and self-efficacy. The study highlights the potential impacts of young onset dementia on dexterity, health-related quality of life, and self-efficacy. More longitudinal research is needed to assess the time course of this impact and explore support strategies.
KW - cognitive function
KW - neurodegenerative disease
KW - Self-efficacy
KW - Dexterity and bimanual coordination
KW - Anxiety
KW - Sleep, depression, comparative study, age-matched healthy controls, quality of life
KW - Health
KW - Young-onset dementia
U2 - 10.1016/j.amjmed.2025.05.034
DO - 10.1016/j.amjmed.2025.05.034
M3 - Journal article
C2 - 40472955
JO - The American Journal of Medicine
JF - The American Journal of Medicine
SN - 0002-9343
ER -