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Does peripheral neuropathy invariably accompany nephropathy in type 1 diabetes mellitus?

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Does peripheral neuropathy invariably accompany nephropathy in type 1 diabetes mellitus? / Shaw, J. E.; Gokal, R.; Hollis, Sally et al.
In: Diabetes Research and Clincal Practice, Vol. 39, No. 1, 01.1998, p. 55-61.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Shaw, JE, Gokal, R, Hollis, S & Boulton, AJM 1998, 'Does peripheral neuropathy invariably accompany nephropathy in type 1 diabetes mellitus?', Diabetes Research and Clincal Practice, vol. 39, no. 1, pp. 55-61. https://doi.org/10.1016/S0168-8227(97)00122-8

APA

Shaw, J. E., Gokal, R., Hollis, S., & Boulton, A. J. M. (1998). Does peripheral neuropathy invariably accompany nephropathy in type 1 diabetes mellitus? Diabetes Research and Clincal Practice, 39(1), 55-61. https://doi.org/10.1016/S0168-8227(97)00122-8

Vancouver

Shaw JE, Gokal R, Hollis S, Boulton AJM. Does peripheral neuropathy invariably accompany nephropathy in type 1 diabetes mellitus? Diabetes Research and Clincal Practice. 1998 Jan;39(1):55-61. doi: 10.1016/S0168-8227(97)00122-8

Author

Shaw, J. E. ; Gokal, R. ; Hollis, Sally et al. / Does peripheral neuropathy invariably accompany nephropathy in type 1 diabetes mellitus?. In: Diabetes Research and Clincal Practice. 1998 ; Vol. 39, No. 1. pp. 55-61.

Bibtex

@article{555e92569eb44095a4d39bc8424e17fa,
title = "Does peripheral neuropathy invariably accompany nephropathy in type 1 diabetes mellitus?",
abstract = "In patients with Type 1 diabetes mellitus complicated by diabetic nephropathy and retinopathy, it is usually believed that significant neuropathy is almost universal, but few studies have directly addressed this. This study assessed neuropathy in 91 such subjects, using vibration perception thresholds (VPT) and the neuropathy disability score (NDS). A total of 34% of subjects had no neuropathy on age adjusted VPT (z score) and 26% had no neuropathy on NDS. The severity of neuropathy as measured by VPT z score was related to increasing glycated haemoglobin (P=0.02) and male sex (P=0.03), and NDS was independently associated with age (P<0.0001) and HbA1c (P=0.003). These factors together accounted for only 12 and 31% of the total variance in VPT z score and NDS, respectively. In conclusion, the study has shown that a significant proportion of patients with diabetic nephropathy are free of neuropathy, but the full explanation for their protection from neuropathy is unclear.",
keywords = "Diabetic neuropathy, Diabetic nephropathy, Diabetes mellitus, Renal transplantation",
author = "Shaw, {J. E.} and R. Gokal and Sally Hollis and Boulton, {A. J. M.}",
year = "1998",
month = jan,
doi = "10.1016/S0168-8227(97)00122-8",
language = "English",
volume = "39",
pages = "55--61",
journal = "Diabetes Research and Clincal Practice",
issn = "0168-8227",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Does peripheral neuropathy invariably accompany nephropathy in type 1 diabetes mellitus?

AU - Shaw, J. E.

AU - Gokal, R.

AU - Hollis, Sally

AU - Boulton, A. J. M.

PY - 1998/1

Y1 - 1998/1

N2 - In patients with Type 1 diabetes mellitus complicated by diabetic nephropathy and retinopathy, it is usually believed that significant neuropathy is almost universal, but few studies have directly addressed this. This study assessed neuropathy in 91 such subjects, using vibration perception thresholds (VPT) and the neuropathy disability score (NDS). A total of 34% of subjects had no neuropathy on age adjusted VPT (z score) and 26% had no neuropathy on NDS. The severity of neuropathy as measured by VPT z score was related to increasing glycated haemoglobin (P=0.02) and male sex (P=0.03), and NDS was independently associated with age (P<0.0001) and HbA1c (P=0.003). These factors together accounted for only 12 and 31% of the total variance in VPT z score and NDS, respectively. In conclusion, the study has shown that a significant proportion of patients with diabetic nephropathy are free of neuropathy, but the full explanation for their protection from neuropathy is unclear.

AB - In patients with Type 1 diabetes mellitus complicated by diabetic nephropathy and retinopathy, it is usually believed that significant neuropathy is almost universal, but few studies have directly addressed this. This study assessed neuropathy in 91 such subjects, using vibration perception thresholds (VPT) and the neuropathy disability score (NDS). A total of 34% of subjects had no neuropathy on age adjusted VPT (z score) and 26% had no neuropathy on NDS. The severity of neuropathy as measured by VPT z score was related to increasing glycated haemoglobin (P=0.02) and male sex (P=0.03), and NDS was independently associated with age (P<0.0001) and HbA1c (P=0.003). These factors together accounted for only 12 and 31% of the total variance in VPT z score and NDS, respectively. In conclusion, the study has shown that a significant proportion of patients with diabetic nephropathy are free of neuropathy, but the full explanation for their protection from neuropathy is unclear.

KW - Diabetic neuropathy

KW - Diabetic nephropathy

KW - Diabetes mellitus

KW - Renal transplantation

U2 - 10.1016/S0168-8227(97)00122-8

DO - 10.1016/S0168-8227(97)00122-8

M3 - Journal article

VL - 39

SP - 55

EP - 61

JO - Diabetes Research and Clincal Practice

JF - Diabetes Research and Clincal Practice

SN - 0168-8227

IS - 1

ER -