An energy-balance-based analytical method and finite element (FE) simulations were developed in this paper to study the dynamic response of metallic sandwich panels subject to blast loadings. The analytical model can be used to predict approximately the deflection of the panels, while the FE model can take into account fluid structure interactions and the effect of strain rate. Both models were validated by comparing their predictions with the test results available in the literature. Parametric studies were then carried out to assess various factors that are influential in characterizing the dynamic behavior of sandwich panels subject to blast loads.