Neuroleptics modulate the expression level of some regulatory neuropeptides in the brain. However, if these therapeutics infuence the peptidergic circuits in the amygdala remains unclear. This study specifes the impact profle of the classical antipsychotic drugs on mRNA expression of the spexin/NPQ, kisspeptin-1 and POMC in the rat amygdala. Animals were treated with haloperidol and chlorpromazine for 28 days prior to transcript quantifcation via qPCR. Haloperidol and chlorpromazine induced a change in the expression of all neuropeptides analyzed. Both drugs led to the decrease of Kiss-1 expression, whereas in POMC and spexin/NPQ their up-regulation in the amygdala was detected. These modulating efects on may represent alternative, so far unknown mechanisms, of classical antipsychotic drugs triggering pharmacological responses