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Efect of long‑term treatment with classical neuroleptics on NPQ/ spexin, kisspeptin and POMC mRNA expression in the male rat amygdala

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Efect of long‑term treatment with classical neuroleptics on NPQ/ spexin, kisspeptin and POMC mRNA expression in the male rat amygdala. / Palasz, Artur; Palka, Marcelina; Filipczyk, Lukasz et al.
In: Journal of Neural Transmission, Vol. 125, No. 7, 07.2018, p. 1099-1105.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Palasz, A, Palka, M, Filipczyk, L, Castro Menezes, I, Rojczyk, E, Worthington, JJ, Piwowarczyk-Nowak, A, Krzystanek, M & Wiaderkiewicz, R 2018, 'Efect of long‑term treatment with classical neuroleptics on NPQ/ spexin, kisspeptin and POMC mRNA expression in the male rat amygdala', Journal of Neural Transmission, vol. 125, no. 7, pp. 1099-1105. https://doi.org/10.1007/s00702-018-1868-2

APA

Palasz, A., Palka, M., Filipczyk, L., Castro Menezes, I., Rojczyk, E., Worthington, J. J., Piwowarczyk-Nowak, A., Krzystanek, M., & Wiaderkiewicz, R. (2018). Efect of long‑term treatment with classical neuroleptics on NPQ/ spexin, kisspeptin and POMC mRNA expression in the male rat amygdala. Journal of Neural Transmission, 125(7), 1099-1105. https://doi.org/10.1007/s00702-018-1868-2

Vancouver

Palasz A, Palka M, Filipczyk L, Castro Menezes I, Rojczyk E, Worthington JJ et al. Efect of long‑term treatment with classical neuroleptics on NPQ/ spexin, kisspeptin and POMC mRNA expression in the male rat amygdala. Journal of Neural Transmission. 2018 Jul;125(7):1099-1105. Epub 2018 Feb 27. doi: 10.1007/s00702-018-1868-2

Author

Palasz, Artur ; Palka, Marcelina ; Filipczyk, Lukasz et al. / Efect of long‑term treatment with classical neuroleptics on NPQ/ spexin, kisspeptin and POMC mRNA expression in the male rat amygdala. In: Journal of Neural Transmission. 2018 ; Vol. 125, No. 7. pp. 1099-1105.

Bibtex

@article{52c834a479c644de8ddf9a4301ad7ea8,
title = "Efect of long‑term treatment with classical neuroleptics on NPQ/ spexin, kisspeptin and POMC mRNA expression in the male rat amygdala",
abstract = "Neuroleptics modulate the expression level of some regulatory neuropeptides in the brain. However, if these therapeutics infuence the peptidergic circuits in the amygdala remains unclear. This study specifes the impact profle of the classical antipsychotic drugs on mRNA expression of the spexin/NPQ, kisspeptin-1 and POMC in the rat amygdala. Animals were treated with haloperidol and chlorpromazine for 28 days prior to transcript quantifcation via qPCR. Haloperidol and chlorpromazine induced a change in the expression of all neuropeptides analyzed. Both drugs led to the decrease of Kiss-1 expression, whereas in POMC and spexin/NPQ their up-regulation in the amygdala was detected. These modulating efects on may represent alternative, so far unknown mechanisms, of classical antipsychotic drugs triggering pharmacological responses",
keywords = "Amygdala , Spexin , Kisspeptin, POMC, Chlorpromazine, Haloperidol ",
author = "Artur Palasz and Marcelina Palka and Lukasz Filipczyk and {Castro Menezes}, Itiana and Ewa Rojczyk and Worthington, {John Joseph} and Aneta Piwowarczyk-Nowak and Marek Krzystanek and Ryszard Wiaderkiewicz",
year = "2018",
month = jul,
doi = "10.1007/s00702-018-1868-2",
language = "English",
volume = "125",
pages = "1099--1105",
journal = "Journal of Neural Transmission",
issn = "0300-9564",
publisher = "Springer Verlag",
number = "7",

}

RIS

TY - JOUR

T1 - Efect of long‑term treatment with classical neuroleptics on NPQ/ spexin, kisspeptin and POMC mRNA expression in the male rat amygdala

AU - Palasz, Artur

AU - Palka, Marcelina

AU - Filipczyk, Lukasz

AU - Castro Menezes, Itiana

AU - Rojczyk, Ewa

AU - Worthington, John Joseph

AU - Piwowarczyk-Nowak, Aneta

AU - Krzystanek, Marek

AU - Wiaderkiewicz, Ryszard

PY - 2018/7

Y1 - 2018/7

N2 - Neuroleptics modulate the expression level of some regulatory neuropeptides in the brain. However, if these therapeutics infuence the peptidergic circuits in the amygdala remains unclear. This study specifes the impact profle of the classical antipsychotic drugs on mRNA expression of the spexin/NPQ, kisspeptin-1 and POMC in the rat amygdala. Animals were treated with haloperidol and chlorpromazine for 28 days prior to transcript quantifcation via qPCR. Haloperidol and chlorpromazine induced a change in the expression of all neuropeptides analyzed. Both drugs led to the decrease of Kiss-1 expression, whereas in POMC and spexin/NPQ their up-regulation in the amygdala was detected. These modulating efects on may represent alternative, so far unknown mechanisms, of classical antipsychotic drugs triggering pharmacological responses

AB - Neuroleptics modulate the expression level of some regulatory neuropeptides in the brain. However, if these therapeutics infuence the peptidergic circuits in the amygdala remains unclear. This study specifes the impact profle of the classical antipsychotic drugs on mRNA expression of the spexin/NPQ, kisspeptin-1 and POMC in the rat amygdala. Animals were treated with haloperidol and chlorpromazine for 28 days prior to transcript quantifcation via qPCR. Haloperidol and chlorpromazine induced a change in the expression of all neuropeptides analyzed. Both drugs led to the decrease of Kiss-1 expression, whereas in POMC and spexin/NPQ their up-regulation in the amygdala was detected. These modulating efects on may represent alternative, so far unknown mechanisms, of classical antipsychotic drugs triggering pharmacological responses

KW - Amygdala

KW - Spexin

KW - Kisspeptin

KW - POMC

KW - Chlorpromazine

KW - Haloperidol

U2 - 10.1007/s00702-018-1868-2

DO - 10.1007/s00702-018-1868-2

M3 - Journal article

VL - 125

SP - 1099

EP - 1105

JO - Journal of Neural Transmission

JF - Journal of Neural Transmission

SN - 0300-9564

IS - 7

ER -