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Effective screening of Coulomb repulsions in water accelerates reactions of like-charged compounds by orders of magnitude

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Effective screening of Coulomb repulsions in water accelerates reactions of like-charged compounds by orders of magnitude. / Kowalski, Adam; Bielec, Krzysztof; Bubak, Grzegorz et al.
In: Nature Communications, Vol. 13, 451, 28.10.2022.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Kowalski, A, Bielec, K, Bubak, G, Zuk, P, Czjakowski, M, Sashuk, V, Huck, W, Antosiewicz, J & Hołyst, R 2022, 'Effective screening of Coulomb repulsions in water accelerates reactions of like-charged compounds by orders of magnitude', Nature Communications, vol. 13, 451. https://doi.org/10.1038/s41467-022-34182-z

APA

Kowalski, A., Bielec, K., Bubak, G., Zuk, P., Czjakowski, M., Sashuk, V., Huck, W., Antosiewicz, J., & Hołyst, R. (2022). Effective screening of Coulomb repulsions in water accelerates reactions of like-charged compounds by orders of magnitude. Nature Communications, 13, Article 451. https://doi.org/10.1038/s41467-022-34182-z

Vancouver

Kowalski A, Bielec K, Bubak G, Zuk P, Czjakowski M, Sashuk V et al. Effective screening of Coulomb repulsions in water accelerates reactions of like-charged compounds by orders of magnitude. Nature Communications. 2022 Oct 28;13:451. doi: 10.1038/s41467-022-34182-z

Author

Kowalski, Adam ; Bielec, Krzysztof ; Bubak, Grzegorz et al. / Effective screening of Coulomb repulsions in water accelerates reactions of like-charged compounds by orders of magnitude. In: Nature Communications. 2022 ; Vol. 13.

Bibtex

@article{0b00f3e945ca48d698b5e91cc4b0c1e0,
title = "Effective screening of Coulomb repulsions in water accelerates reactions of like-charged compounds by orders of magnitude",
abstract = "The reaction kinetics between like-charged compounds in water is extremely slow due to Coulomb repulsions. Here, we demonstrate that by screening these interactions and, in consequence, increasing the local concentration of reactants, we boost the reactions by many orders of magnitude. The reaction between negatively charged Coenzyme A molecules accelerates ~5 million-fold using cationic micelles. That is ~104 faster kinetics than in 0.5 M NaCl, although the salt is ~106 more concentrated. Rate enhancements are not limited to micelles, as evidenced by significant catalytic effects (104–105-fold) of other highly charged species such as oligomers and polymers. We generalize the observed phenomenon by analogously speeding up a non-covalent complex formation—DNA hybridization. A theoretical analysis shows that the acceleration is correlated to the catalysts{\textquoteright} surface charge density in both experimental systems and enables predicting and controlling reaction rates of like-charged compounds with counter-charged species.",
author = "Adam Kowalski and Krzysztof Bielec and Grzegorz Bubak and Pawel Zuk and Maciej Czjakowski and Volodymyr Sashuk and Wilhelm Huck and Jan Antosiewicz and Robert Ho{\l}yst",
year = "2022",
month = oct,
day = "28",
doi = "10.1038/s41467-022-34182-z",
language = "English",
volume = "13",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Effective screening of Coulomb repulsions in water accelerates reactions of like-charged compounds by orders of magnitude

AU - Kowalski, Adam

AU - Bielec, Krzysztof

AU - Bubak, Grzegorz

AU - Zuk, Pawel

AU - Czjakowski, Maciej

AU - Sashuk, Volodymyr

AU - Huck, Wilhelm

AU - Antosiewicz, Jan

AU - Hołyst, Robert

PY - 2022/10/28

Y1 - 2022/10/28

N2 - The reaction kinetics between like-charged compounds in water is extremely slow due to Coulomb repulsions. Here, we demonstrate that by screening these interactions and, in consequence, increasing the local concentration of reactants, we boost the reactions by many orders of magnitude. The reaction between negatively charged Coenzyme A molecules accelerates ~5 million-fold using cationic micelles. That is ~104 faster kinetics than in 0.5 M NaCl, although the salt is ~106 more concentrated. Rate enhancements are not limited to micelles, as evidenced by significant catalytic effects (104–105-fold) of other highly charged species such as oligomers and polymers. We generalize the observed phenomenon by analogously speeding up a non-covalent complex formation—DNA hybridization. A theoretical analysis shows that the acceleration is correlated to the catalysts’ surface charge density in both experimental systems and enables predicting and controlling reaction rates of like-charged compounds with counter-charged species.

AB - The reaction kinetics between like-charged compounds in water is extremely slow due to Coulomb repulsions. Here, we demonstrate that by screening these interactions and, in consequence, increasing the local concentration of reactants, we boost the reactions by many orders of magnitude. The reaction between negatively charged Coenzyme A molecules accelerates ~5 million-fold using cationic micelles. That is ~104 faster kinetics than in 0.5 M NaCl, although the salt is ~106 more concentrated. Rate enhancements are not limited to micelles, as evidenced by significant catalytic effects (104–105-fold) of other highly charged species such as oligomers and polymers. We generalize the observed phenomenon by analogously speeding up a non-covalent complex formation—DNA hybridization. A theoretical analysis shows that the acceleration is correlated to the catalysts’ surface charge density in both experimental systems and enables predicting and controlling reaction rates of like-charged compounds with counter-charged species.

U2 - 10.1038/s41467-022-34182-z

DO - 10.1038/s41467-022-34182-z

M3 - Journal article

VL - 13

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 451

ER -