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Effects of an intervention to promote breastfeeding on maternal adiposity and blood pressure at 11.5 y postpartum: results from the Promotion of Breastfeeding Intervention Trial, a cluster-randomized controlled trial

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Effects of an intervention to promote breastfeeding on maternal adiposity and blood pressure at 11.5 y postpartum : results from the Promotion of Breastfeeding Intervention Trial, a cluster-randomized controlled trial. / Oken, Emily; Patel, Rita; Guthrie, Lauren B.; Vilchuck, Konstantin; Bogdanovich, Natalia; Sergeichick, Natalia; Palmer, Tom M.; Kramer, Michael S.; Martin, Richard M.

In: American Journal of Clinical Nutrition, Vol. 98, No. 4, 10.2013, p. 1048-1056.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Oken, E, Patel, R, Guthrie, LB, Vilchuck, K, Bogdanovich, N, Sergeichick, N, Palmer, TM, Kramer, MS & Martin, RM 2013, 'Effects of an intervention to promote breastfeeding on maternal adiposity and blood pressure at 11.5 y postpartum: results from the Promotion of Breastfeeding Intervention Trial, a cluster-randomized controlled trial', American Journal of Clinical Nutrition, vol. 98, no. 4, pp. 1048-1056. https://doi.org/10.3945/ajcn.113.065300

APA

Oken, E., Patel, R., Guthrie, L. B., Vilchuck, K., Bogdanovich, N., Sergeichick, N., Palmer, T. M., Kramer, M. S., & Martin, R. M. (2013). Effects of an intervention to promote breastfeeding on maternal adiposity and blood pressure at 11.5 y postpartum: results from the Promotion of Breastfeeding Intervention Trial, a cluster-randomized controlled trial. American Journal of Clinical Nutrition, 98(4), 1048-1056. https://doi.org/10.3945/ajcn.113.065300

Vancouver

Author

Oken, Emily ; Patel, Rita ; Guthrie, Lauren B. ; Vilchuck, Konstantin ; Bogdanovich, Natalia ; Sergeichick, Natalia ; Palmer, Tom M. ; Kramer, Michael S. ; Martin, Richard M. / Effects of an intervention to promote breastfeeding on maternal adiposity and blood pressure at 11.5 y postpartum : results from the Promotion of Breastfeeding Intervention Trial, a cluster-randomized controlled trial. In: American Journal of Clinical Nutrition. 2013 ; Vol. 98, No. 4. pp. 1048-1056.

Bibtex

@article{ad12008355194e47b49ad75d8e0a4f63,
title = "Effects of an intervention to promote breastfeeding on maternal adiposity and blood pressure at 11.5 y postpartum: results from the Promotion of Breastfeeding Intervention Trial, a cluster-randomized controlled trial",
abstract = "BACKGROUND: Differences between mothers who do and do not succeed in breastfeeding are likely to confound associations of lactation with later maternal adiposity.OBJECTIVE: We compared adiposity and blood pressure (BP) in women randomly assigned to an intervention to promote prolonged and exclusive breastfeeding or usual care.DESIGN: We performed a cluster-randomized trial at 31 hospitals in Belarus in 1996-1997.RESULTS: Of 17,046 women enrolled at delivery, we assessed 11,867 women (69.6%) at 11.5 y postpartum. The prevalence of exclusive breastfeeding ≥3 mo was 44.5% in 6321 women in the intervention group and 7.1% in 5546 women in the control group. At 11.5 y postpartum, mean (±SD) body mass index (BMI; in kg/m(2)) was 26.5 ± 5.5, the percentage of body fat was 33.6% ± 8.3%, and systolic BP was 124.6 ± 14.6 mm Hg. On intention-to-treat analysis (without imputation) with adjustment for clustering by hospital, mean outcomes were lower in intervention compared with control mothers for BMI (mean difference: -0.27; 95% CI: -0.91, 0.37), body fat (-0.49%; 95% CI: -1.25%, 0.27%), and systolic BP (-0.81 mm Hg; 95% CI: -3.33, 1.71 mm Hg), but effect sizes were small, CIs were wide, and results were attenuated further toward the null after adjustment for baseline characteristics. Results were similar in sensitivity analyses [ie, by using conventional observational analyses disregarding treatment assignment, instrumental variable analyses to estimate the causal effect of breastfeeding, and multiple imputation to account for missing outcome measures (n = 17,046)].CONCLUSION: In women who initiated breastfeeding, an intervention to promote longer breastfeeding duration did not result in an important lowering of adiposity or BP. This trial was registered at clinicaltrials.gov as NCT01561612 and at Current Controlled Trials as ISRCTN37687716.",
keywords = "Adiposity, Adult, Blood Pressure, Body Mass Index, Breast Feeding, Female, Follow-Up Studies, Health Promotion, Humans, Lactation, Maternal Welfare, Pregnancy, Quality Assurance, Health Care, Republic of Belarus, Time Factors",
author = "Emily Oken and Rita Patel and Guthrie, {Lauren B.} and Konstantin Vilchuck and Natalia Bogdanovich and Natalia Sergeichick and Palmer, {Tom M.} and Kramer, {Michael S.} and Martin, {Richard M.}",
year = "2013",
month = oct,
doi = "10.3945/ajcn.113.065300",
language = "English",
volume = "98",
pages = "1048--1056",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "4",

}

RIS

TY - JOUR

T1 - Effects of an intervention to promote breastfeeding on maternal adiposity and blood pressure at 11.5 y postpartum

T2 - results from the Promotion of Breastfeeding Intervention Trial, a cluster-randomized controlled trial

AU - Oken, Emily

AU - Patel, Rita

AU - Guthrie, Lauren B.

AU - Vilchuck, Konstantin

AU - Bogdanovich, Natalia

AU - Sergeichick, Natalia

AU - Palmer, Tom M.

AU - Kramer, Michael S.

AU - Martin, Richard M.

PY - 2013/10

Y1 - 2013/10

N2 - BACKGROUND: Differences between mothers who do and do not succeed in breastfeeding are likely to confound associations of lactation with later maternal adiposity.OBJECTIVE: We compared adiposity and blood pressure (BP) in women randomly assigned to an intervention to promote prolonged and exclusive breastfeeding or usual care.DESIGN: We performed a cluster-randomized trial at 31 hospitals in Belarus in 1996-1997.RESULTS: Of 17,046 women enrolled at delivery, we assessed 11,867 women (69.6%) at 11.5 y postpartum. The prevalence of exclusive breastfeeding ≥3 mo was 44.5% in 6321 women in the intervention group and 7.1% in 5546 women in the control group. At 11.5 y postpartum, mean (±SD) body mass index (BMI; in kg/m(2)) was 26.5 ± 5.5, the percentage of body fat was 33.6% ± 8.3%, and systolic BP was 124.6 ± 14.6 mm Hg. On intention-to-treat analysis (without imputation) with adjustment for clustering by hospital, mean outcomes were lower in intervention compared with control mothers for BMI (mean difference: -0.27; 95% CI: -0.91, 0.37), body fat (-0.49%; 95% CI: -1.25%, 0.27%), and systolic BP (-0.81 mm Hg; 95% CI: -3.33, 1.71 mm Hg), but effect sizes were small, CIs were wide, and results were attenuated further toward the null after adjustment for baseline characteristics. Results were similar in sensitivity analyses [ie, by using conventional observational analyses disregarding treatment assignment, instrumental variable analyses to estimate the causal effect of breastfeeding, and multiple imputation to account for missing outcome measures (n = 17,046)].CONCLUSION: In women who initiated breastfeeding, an intervention to promote longer breastfeeding duration did not result in an important lowering of adiposity or BP. This trial was registered at clinicaltrials.gov as NCT01561612 and at Current Controlled Trials as ISRCTN37687716.

AB - BACKGROUND: Differences between mothers who do and do not succeed in breastfeeding are likely to confound associations of lactation with later maternal adiposity.OBJECTIVE: We compared adiposity and blood pressure (BP) in women randomly assigned to an intervention to promote prolonged and exclusive breastfeeding or usual care.DESIGN: We performed a cluster-randomized trial at 31 hospitals in Belarus in 1996-1997.RESULTS: Of 17,046 women enrolled at delivery, we assessed 11,867 women (69.6%) at 11.5 y postpartum. The prevalence of exclusive breastfeeding ≥3 mo was 44.5% in 6321 women in the intervention group and 7.1% in 5546 women in the control group. At 11.5 y postpartum, mean (±SD) body mass index (BMI; in kg/m(2)) was 26.5 ± 5.5, the percentage of body fat was 33.6% ± 8.3%, and systolic BP was 124.6 ± 14.6 mm Hg. On intention-to-treat analysis (without imputation) with adjustment for clustering by hospital, mean outcomes were lower in intervention compared with control mothers for BMI (mean difference: -0.27; 95% CI: -0.91, 0.37), body fat (-0.49%; 95% CI: -1.25%, 0.27%), and systolic BP (-0.81 mm Hg; 95% CI: -3.33, 1.71 mm Hg), but effect sizes were small, CIs were wide, and results were attenuated further toward the null after adjustment for baseline characteristics. Results were similar in sensitivity analyses [ie, by using conventional observational analyses disregarding treatment assignment, instrumental variable analyses to estimate the causal effect of breastfeeding, and multiple imputation to account for missing outcome measures (n = 17,046)].CONCLUSION: In women who initiated breastfeeding, an intervention to promote longer breastfeeding duration did not result in an important lowering of adiposity or BP. This trial was registered at clinicaltrials.gov as NCT01561612 and at Current Controlled Trials as ISRCTN37687716.

KW - Adiposity

KW - Adult

KW - Blood Pressure

KW - Body Mass Index

KW - Breast Feeding

KW - Female

KW - Follow-Up Studies

KW - Health Promotion

KW - Humans

KW - Lactation

KW - Maternal Welfare

KW - Pregnancy

KW - Quality Assurance, Health Care

KW - Republic of Belarus

KW - Time Factors

U2 - 10.3945/ajcn.113.065300

DO - 10.3945/ajcn.113.065300

M3 - Journal article

C2 - 23945719

VL - 98

SP - 1048

EP - 1056

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 4

ER -