Home > Research > Publications & Outputs > Effects of Maternal Worm Infections and Anthelm...
View graph of relations

Effects of Maternal Worm Infections and Anthelminthic Treatment during Pregnancy on Infant Motor and Neurocognitive Functioning

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Published

Standard

Effects of Maternal Worm Infections and Anthelminthic Treatment during Pregnancy on Infant Motor and Neurocognitive Functioning. / Nampijja, Margaret; Apule, Barbara; Lule, Swaib; Akurut, Hellen; Muhangi, Lawrence; Webb, Emily L; Lewis, Charlie; Elliott, Alison M; Alcock, Katie J.

In: Journal of the International Neuropsychological Society, Vol. 18, No. 6, 11.2012, p. 1019-1030.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Nampijja, M, Apule, B, Lule, S, Akurut, H, Muhangi, L, Webb, EL, Lewis, C, Elliott, AM & Alcock, KJ 2012, 'Effects of Maternal Worm Infections and Anthelminthic Treatment during Pregnancy on Infant Motor and Neurocognitive Functioning', Journal of the International Neuropsychological Society, vol. 18, no. 6, pp. 1019-1030. https://doi.org/10.1017/S1355617712000768

APA

Nampijja, M., Apule, B., Lule, S., Akurut, H., Muhangi, L., Webb, E. L., Lewis, C., Elliott, A. M., & Alcock, K. J. (2012). Effects of Maternal Worm Infections and Anthelminthic Treatment during Pregnancy on Infant Motor and Neurocognitive Functioning. Journal of the International Neuropsychological Society, 18(6), 1019-1030. https://doi.org/10.1017/S1355617712000768

Vancouver

Nampijja M, Apule B, Lule S, Akurut H, Muhangi L, Webb EL et al. Effects of Maternal Worm Infections and Anthelminthic Treatment during Pregnancy on Infant Motor and Neurocognitive Functioning. Journal of the International Neuropsychological Society. 2012 Nov;18(6):1019-1030. https://doi.org/10.1017/S1355617712000768

Author

Nampijja, Margaret ; Apule, Barbara ; Lule, Swaib ; Akurut, Hellen ; Muhangi, Lawrence ; Webb, Emily L ; Lewis, Charlie ; Elliott, Alison M ; Alcock, Katie J. / Effects of Maternal Worm Infections and Anthelminthic Treatment during Pregnancy on Infant Motor and Neurocognitive Functioning. In: Journal of the International Neuropsychological Society. 2012 ; Vol. 18, No. 6. pp. 1019-1030.

Bibtex

@article{c5164e73f8624d4998ecb394de349f49,
title = "Effects of Maternal Worm Infections and Anthelminthic Treatment during Pregnancy on Infant Motor and Neurocognitive Functioning",
abstract = "We tested the hypothesis that maternal worm infections in pregnancy affect infant motor and neurocognitive development, and that anthelminthic treatment during pregnancy can reverse these effects. We used measures which examine infant motor, cognitive and executive function, including inhibition. We assessed 983 Ugandan infants aged 15 months, using locally appropriate measures within the Entebbe Mother and Baby Study, a trial of anthelminthic treatment during pregnancy. Key exposures were maternal worm infections and anthelminthic treatment during pregnancy. Effects of other health and social factors were controlled for statistically. Of the five major worm species found in the pregnant women, two had influences on the developmental measures: Maternal Mansonella perstans and Strongyloides stercoralis infections showed negative associations with the A-not B-task, and Language, respectively. Performance on other psychomotor and cognitive measures was associated with illnesses during infancy and infants' behavior during assessment, but not with maternal worm infections. There were no positive effects of maternal anthelminthic treatment on infant abilities. Mansonella perstans and Strongyloides stercoralis infection during pregnancy seem associated with impaired early executive function and language, respectively, but single-dose anthelminthic treatment during pregnancy was not beneficial. The biological mechanisms that could underlie these neurocognitive effects are discussed. (JINS, 2012, 18, 1019-1030).",
keywords = "Pregnancy, Helminths, De-worming, Infancy, Psychomotor, Executive function",
author = "Margaret Nampijja and Barbara Apule and Swaib Lule and Hellen Akurut and Lawrence Muhangi and Webb, {Emily L} and Charlie Lewis and Elliott, {Alison M} and Alcock, {Katie J}",
note = "http://journals.cambridge.org/action/displayJournal?jid=INS The final, definitive version of this article has been published in the Journal, Journal of the International Neuropsychological Society, 18, (6) pp 1019-1030 2012, {\textcopyright} 2012 Cambridge University Press.",
year = "2012",
month = nov,
doi = "10.1017/S1355617712000768",
language = "English",
volume = "18",
pages = "1019--1030",
journal = "Journal of the International Neuropsychological Society",
issn = "1355-6177",
publisher = "Cambridge University Press",
number = "6",

}

RIS

TY - JOUR

T1 - Effects of Maternal Worm Infections and Anthelminthic Treatment during Pregnancy on Infant Motor and Neurocognitive Functioning

AU - Nampijja, Margaret

AU - Apule, Barbara

AU - Lule, Swaib

AU - Akurut, Hellen

AU - Muhangi, Lawrence

AU - Webb, Emily L

AU - Lewis, Charlie

AU - Elliott, Alison M

AU - Alcock, Katie J

N1 - http://journals.cambridge.org/action/displayJournal?jid=INS The final, definitive version of this article has been published in the Journal, Journal of the International Neuropsychological Society, 18, (6) pp 1019-1030 2012, © 2012 Cambridge University Press.

PY - 2012/11

Y1 - 2012/11

N2 - We tested the hypothesis that maternal worm infections in pregnancy affect infant motor and neurocognitive development, and that anthelminthic treatment during pregnancy can reverse these effects. We used measures which examine infant motor, cognitive and executive function, including inhibition. We assessed 983 Ugandan infants aged 15 months, using locally appropriate measures within the Entebbe Mother and Baby Study, a trial of anthelminthic treatment during pregnancy. Key exposures were maternal worm infections and anthelminthic treatment during pregnancy. Effects of other health and social factors were controlled for statistically. Of the five major worm species found in the pregnant women, two had influences on the developmental measures: Maternal Mansonella perstans and Strongyloides stercoralis infections showed negative associations with the A-not B-task, and Language, respectively. Performance on other psychomotor and cognitive measures was associated with illnesses during infancy and infants' behavior during assessment, but not with maternal worm infections. There were no positive effects of maternal anthelminthic treatment on infant abilities. Mansonella perstans and Strongyloides stercoralis infection during pregnancy seem associated with impaired early executive function and language, respectively, but single-dose anthelminthic treatment during pregnancy was not beneficial. The biological mechanisms that could underlie these neurocognitive effects are discussed. (JINS, 2012, 18, 1019-1030).

AB - We tested the hypothesis that maternal worm infections in pregnancy affect infant motor and neurocognitive development, and that anthelminthic treatment during pregnancy can reverse these effects. We used measures which examine infant motor, cognitive and executive function, including inhibition. We assessed 983 Ugandan infants aged 15 months, using locally appropriate measures within the Entebbe Mother and Baby Study, a trial of anthelminthic treatment during pregnancy. Key exposures were maternal worm infections and anthelminthic treatment during pregnancy. Effects of other health and social factors were controlled for statistically. Of the five major worm species found in the pregnant women, two had influences on the developmental measures: Maternal Mansonella perstans and Strongyloides stercoralis infections showed negative associations with the A-not B-task, and Language, respectively. Performance on other psychomotor and cognitive measures was associated with illnesses during infancy and infants' behavior during assessment, but not with maternal worm infections. There were no positive effects of maternal anthelminthic treatment on infant abilities. Mansonella perstans and Strongyloides stercoralis infection during pregnancy seem associated with impaired early executive function and language, respectively, but single-dose anthelminthic treatment during pregnancy was not beneficial. The biological mechanisms that could underlie these neurocognitive effects are discussed. (JINS, 2012, 18, 1019-1030).

KW - Pregnancy

KW - Helminths

KW - De-worming

KW - Infancy

KW - Psychomotor

KW - Executive function

UR - http://www.scopus.com/inward/record.url?scp=84870184409&partnerID=8YFLogxK

U2 - 10.1017/S1355617712000768

DO - 10.1017/S1355617712000768

M3 - Journal article

C2 - 23158229

VL - 18

SP - 1019

EP - 1030

JO - Journal of the International Neuropsychological Society

JF - Journal of the International Neuropsychological Society

SN - 1355-6177

IS - 6

ER -