Electrochemically Enhanced Drug Delivery Using Polypyrrole Films

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

Electrochemically Enhanced Drug Delivery Using Polypyrrole Films. / Shah, Sayed Ashfaq Ali; Firlak, Melike; Berrow, Stuart et al.
In: Materials, Vol. 11, No. 7, 1123, 01.07.2018.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Shah, SAA, Firlak, M, Berrow, S, Halcovitch, N , Baldock, SJ, Yousafzai, B, Hathout, R & Hardy, JG 2018, 'Electrochemically Enhanced Drug Delivery Using Polypyrrole Films', Materials, vol. 11, no. 7, 1123. https://doi.org/10.3390/ma11071123

APA

Shah, S. A. A., Firlak, M., Berrow, S., Halcovitch, N., Baldock, S. J., Yousafzai, B., Hathout, R., & Hardy, J. G. (2018). Electrochemically Enhanced Drug Delivery Using Polypyrrole Films. Materials, 11(7), Article 1123. https://doi.org/10.3390/ma11071123

Vancouver

Shah SAA, Firlak M, Berrow S, Halcovitch N , Baldock SJ, Yousafzai B et al. Electrochemically Enhanced Drug Delivery Using Polypyrrole Films. Materials. 2018 Jul 1;11(7):1123. doi: 10.3390/ma11071123

Author

Shah, Sayed Ashfaq Ali ; Firlak, Melike ; Berrow, Stuart et al. / Electrochemically Enhanced Drug Delivery Using Polypyrrole Films. In: Materials. 2018 ; Vol. 11, No. 7.

Bibtex

@article{4e332433adb54ef0a1a6a29d449367fc,

title = "Electrochemically Enhanced Drug Delivery Using Polypyrrole Films",

abstract = "The delivery of drugs in a controllable fashion is a topic of intense research activity in both academia and industry because of its impact in healthcare. Implantable electronic interfaces for the body have great potential for positive economic, health, and societal impacts; however, the implantation of such interfaces results in inflammatory responses due to a mechanical mismatch between the inorganic substrate and soft tissue, and also results in the potential for microbial infection during complex surgical procedures. Here, we report the use of conducting polypyrrole (PPY)-based coatings loaded with clinically relevant drugs (either an anti-inflammatory, dexamethasone phosphate (DMP), or an antibiotic, meropenem (MER)). The films were characterized and were shown to enhance the delivery of the drugs upon the application of an electrochemical stimulus in vitro, by circa (ca.) 10–30% relative to the passive release from non-stimulated samples. Interestingly, the loading and release of the drugs was correlated with the physical descriptors of the drugs. In the long term, such materials have the potential for application to the surfaces of medical devices to diminish adverse reactions to their implantation in vivo.",

keywords = "bioelectronics, drug delivery, biomaterials, conducting polymers, electroactive polymers, medical devices, neuromodulation",

author = "Shah, {Sayed Ashfaq Ali} and Melike Firlak and Stuart Berrow and Nathan Halcovitch and Baldock, {Sara Jane} and Bakhtiar Yousafzai and Rania Hathout and Hardy, {John George}",

year = "2018",

month = jul,

day = "1",

doi = "10.3390/ma11071123",

language = "English",

volume = "11",

journal = "Materials",

issn = "1996-1944",

publisher = "MDPI AG",

number = "7",

}

RIS

TY - JOUR

T1 - Electrochemically Enhanced Drug Delivery Using Polypyrrole Films

AU - Shah, Sayed Ashfaq Ali

AU - Firlak, Melike

AU - Berrow, Stuart

AU - Halcovitch, Nathan

AU - Baldock, Sara Jane

AU - Yousafzai, Bakhtiar

AU - Hathout, Rania

AU - Hardy, John George

PY - 2018/7/1

Y1 - 2018/7/1

N2 - The delivery of drugs in a controllable fashion is a topic of intense research activity in both academia and industry because of its impact in healthcare. Implantable electronic interfaces for the body have great potential for positive economic, health, and societal impacts; however, the implantation of such interfaces results in inflammatory responses due to a mechanical mismatch between the inorganic substrate and soft tissue, and also results in the potential for microbial infection during complex surgical procedures. Here, we report the use of conducting polypyrrole (PPY)-based coatings loaded with clinically relevant drugs (either an anti-inflammatory, dexamethasone phosphate (DMP), or an antibiotic, meropenem (MER)). The films were characterized and were shown to enhance the delivery of the drugs upon the application of an electrochemical stimulus in vitro, by circa (ca.) 10–30% relative to the passive release from non-stimulated samples. Interestingly, the loading and release of the drugs was correlated with the physical descriptors of the drugs. In the long term, such materials have the potential for application to the surfaces of medical devices to diminish adverse reactions to their implantation in vivo.

AB - The delivery of drugs in a controllable fashion is a topic of intense research activity in both academia and industry because of its impact in healthcare. Implantable electronic interfaces for the body have great potential for positive economic, health, and societal impacts; however, the implantation of such interfaces results in inflammatory responses due to a mechanical mismatch between the inorganic substrate and soft tissue, and also results in the potential for microbial infection during complex surgical procedures. Here, we report the use of conducting polypyrrole (PPY)-based coatings loaded with clinically relevant drugs (either an anti-inflammatory, dexamethasone phosphate (DMP), or an antibiotic, meropenem (MER)). The films were characterized and were shown to enhance the delivery of the drugs upon the application of an electrochemical stimulus in vitro, by circa (ca.) 10–30% relative to the passive release from non-stimulated samples. Interestingly, the loading and release of the drugs was correlated with the physical descriptors of the drugs. In the long term, such materials have the potential for application to the surfaces of medical devices to diminish adverse reactions to their implantation in vivo.

KW - bioelectronics

KW - drug delivery

KW - biomaterials

KW - conducting polymers

KW - electroactive polymers

KW - medical devices

KW - neuromodulation

U2 - 10.3390/ma11071123

DO - 10.3390/ma11071123

M3 - Journal article

VL - 11

JO - Materials

JF - Materials

SN - 1996-1944

IS - 7

M1 - 1123

ER -

Research

Associated organisational unit

Electronic data

Links

Text available via DOI:

Keywords