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Elevated HsCRP in Chronic Obstructive Pulmonary Disease: A Prospective Study of Long-Term Outcomes After Percutaneous Coronary Intervention

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Elevated HsCRP in Chronic Obstructive Pulmonary Disease: A Prospective Study of Long-Term Outcomes After Percutaneous Coronary Intervention. / Zheng, Y.; Qi, Y.; Seery, S. et al.
In: International Journal of COPD, Vol. 17, 07.10.2022, p. 2517-2528.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Zheng, Y, Qi, Y, Seery, S, Yang, J, Li, C, Wang, W, Gao, J, Meng, X, Shao, C & Tang, Y-D 2022, 'Elevated HsCRP in Chronic Obstructive Pulmonary Disease: A Prospective Study of Long-Term Outcomes After Percutaneous Coronary Intervention', International Journal of COPD, vol. 17, pp. 2517-2528. https://doi.org/10.2147/COPD.S380194

APA

Zheng, Y., Qi, Y., Seery, S., Yang, J., Li, C., Wang, W., Gao, J., Meng, X., Shao, C., & Tang, Y-D. (2022). Elevated HsCRP in Chronic Obstructive Pulmonary Disease: A Prospective Study of Long-Term Outcomes After Percutaneous Coronary Intervention. International Journal of COPD, 17, 2517-2528. https://doi.org/10.2147/COPD.S380194

Vancouver

Zheng Y, Qi Y, Seery S, Yang J, Li C, Wang W et al. Elevated HsCRP in Chronic Obstructive Pulmonary Disease: A Prospective Study of Long-Term Outcomes After Percutaneous Coronary Intervention. International Journal of COPD. 2022 Oct 7;17:2517-2528. doi: 10.2147/COPD.S380194

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Bibtex

@article{bd29ca04a61744e38f1b8b6760e1f3ce,
title = "Elevated HsCRP in Chronic Obstructive Pulmonary Disease: A Prospective Study of Long-Term Outcomes After Percutaneous Coronary Intervention",
abstract = "Objective: Anti-inflammatory therapies are reported to have additional benefits beyond lipid control for patients with cardiovascular disease. However, no study has focused on the relationship between inflammation status and long-term outcomes for chronic obstructive pulmonary disease (COPD) patients, after percutaneous coronary intervention (PCI). Methods: 277 COPD-PCI patients were divided into two groups according to hsCRP status upon admission. Major adverse cardiac events (MACE) in high hsCRP patients were compared to patients with low hsCRP. Restricted cubic spline (RCS) analysis was performed using MACE hazard ratios (HR) to investigate interrelations with hsCRP, as a continuous variable. Results: Patients in the high hsCRP group incurred more inflammation activation, in terms of higher white blood cell counts, neutrophil, lymphocytes, and had higher smoking rates, compared to those with lower hsCRPs. A significant increase in MACEs was observed in hsCRP high group, compared to the low hsCRP group (HR: 2.47, 95% CI: 1.22–5.00; p = 0.012). RCS curves suggest that HRs rise beyond 1.0, after the 0.24 juncture for Lg HsCRP (base 10 logarithm with hsCRP), HR per SD: 1.19 (95% CI: 0.96–1.48). Further subgroup analysis implies that elevated hsCRP is associated with a higher risk of MACEs across the sub-groups tested. Conclusion: HsCRP could be a useful indicator for COPD-CAD patient prognosis, after PCI. This is because hsCRP highlights inflammation activation. More multi-center research, designed for COPD-CAD patients should be conducted to more accurately determine the cut-off value for hsCRP. {\textcopyright} 2022 Zheng et al.",
keywords = "chronic obstructive pulmonary disease, coronary artery disease, HsCRP, outcomes, percutaneous coronary intervention",
author = "Y. Zheng and Y. Qi and S. Seery and J. Yang and C. Li and W. Wang and J. Gao and X. Meng and C. Shao and Y.-D. Tang",
note = "Export Date: 20 October 2022",
year = "2022",
month = oct,
day = "7",
doi = "10.2147/COPD.S380194",
language = "English",
volume = "17",
pages = "2517--2528",
journal = "International Journal of COPD",

}

RIS

TY - JOUR

T1 - Elevated HsCRP in Chronic Obstructive Pulmonary Disease

T2 - A Prospective Study of Long-Term Outcomes After Percutaneous Coronary Intervention

AU - Zheng, Y.

AU - Qi, Y.

AU - Seery, S.

AU - Yang, J.

AU - Li, C.

AU - Wang, W.

AU - Gao, J.

AU - Meng, X.

AU - Shao, C.

AU - Tang, Y.-D.

N1 - Export Date: 20 October 2022

PY - 2022/10/7

Y1 - 2022/10/7

N2 - Objective: Anti-inflammatory therapies are reported to have additional benefits beyond lipid control for patients with cardiovascular disease. However, no study has focused on the relationship between inflammation status and long-term outcomes for chronic obstructive pulmonary disease (COPD) patients, after percutaneous coronary intervention (PCI). Methods: 277 COPD-PCI patients were divided into two groups according to hsCRP status upon admission. Major adverse cardiac events (MACE) in high hsCRP patients were compared to patients with low hsCRP. Restricted cubic spline (RCS) analysis was performed using MACE hazard ratios (HR) to investigate interrelations with hsCRP, as a continuous variable. Results: Patients in the high hsCRP group incurred more inflammation activation, in terms of higher white blood cell counts, neutrophil, lymphocytes, and had higher smoking rates, compared to those with lower hsCRPs. A significant increase in MACEs was observed in hsCRP high group, compared to the low hsCRP group (HR: 2.47, 95% CI: 1.22–5.00; p = 0.012). RCS curves suggest that HRs rise beyond 1.0, after the 0.24 juncture for Lg HsCRP (base 10 logarithm with hsCRP), HR per SD: 1.19 (95% CI: 0.96–1.48). Further subgroup analysis implies that elevated hsCRP is associated with a higher risk of MACEs across the sub-groups tested. Conclusion: HsCRP could be a useful indicator for COPD-CAD patient prognosis, after PCI. This is because hsCRP highlights inflammation activation. More multi-center research, designed for COPD-CAD patients should be conducted to more accurately determine the cut-off value for hsCRP. © 2022 Zheng et al.

AB - Objective: Anti-inflammatory therapies are reported to have additional benefits beyond lipid control for patients with cardiovascular disease. However, no study has focused on the relationship between inflammation status and long-term outcomes for chronic obstructive pulmonary disease (COPD) patients, after percutaneous coronary intervention (PCI). Methods: 277 COPD-PCI patients were divided into two groups according to hsCRP status upon admission. Major adverse cardiac events (MACE) in high hsCRP patients were compared to patients with low hsCRP. Restricted cubic spline (RCS) analysis was performed using MACE hazard ratios (HR) to investigate interrelations with hsCRP, as a continuous variable. Results: Patients in the high hsCRP group incurred more inflammation activation, in terms of higher white blood cell counts, neutrophil, lymphocytes, and had higher smoking rates, compared to those with lower hsCRPs. A significant increase in MACEs was observed in hsCRP high group, compared to the low hsCRP group (HR: 2.47, 95% CI: 1.22–5.00; p = 0.012). RCS curves suggest that HRs rise beyond 1.0, after the 0.24 juncture for Lg HsCRP (base 10 logarithm with hsCRP), HR per SD: 1.19 (95% CI: 0.96–1.48). Further subgroup analysis implies that elevated hsCRP is associated with a higher risk of MACEs across the sub-groups tested. Conclusion: HsCRP could be a useful indicator for COPD-CAD patient prognosis, after PCI. This is because hsCRP highlights inflammation activation. More multi-center research, designed for COPD-CAD patients should be conducted to more accurately determine the cut-off value for hsCRP. © 2022 Zheng et al.

KW - chronic obstructive pulmonary disease

KW - coronary artery disease

KW - HsCRP

KW - outcomes

KW - percutaneous coronary intervention

U2 - 10.2147/COPD.S380194

DO - 10.2147/COPD.S380194

M3 - Journal article

VL - 17

SP - 2517

EP - 2528

JO - International Journal of COPD

JF - International Journal of COPD

ER -