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Emergence of Lineage IV Peste des Petits Ruminants Virus in Ethiopia: Complete Genome Sequence of an Ethiopian Isolate 2010

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  • M. Muniraju
  • M. Mahapatra
  • G. Ayelet
  • A. Babu
  • G. Olivier
  • M. Munir
  • G. Libeau
  • C. Batten
  • A. C. Banyard
  • S. Parida
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<mark>Journal publication date</mark>1/08/2016
<mark>Journal</mark>Transboundary and Emerging Diseases
Issue number4
Volume63
Number of pages8
Pages (from-to)435-442
Publication StatusPublished
Early online date14/11/14
<mark>Original language</mark>English

Abstract

Isolates of peste des petits ruminants virus (PPRV) can be segregated genetically into four lineages. For decades, lineages I-III have been reported across Africa whilst lineage IV has predominantly circulated across Asia. However, the lineage distribution is currently changing in Africa. Importantly, full genome sequence data for African field isolates have been lacking. Here, we announce the first complete genome sequence of a field isolate of peste des petits ruminants virus (PPRV) from East Africa. This isolate was derived from the intestine of a goat suffering from severe clinical disease during the 2010 outbreak in Ethiopia. The full genome sequence of this isolate, PPRV Ethiopia/2010, clusters genetically with other lineage IV isolates of PPRV, sharing high levels of sequence identity across the genome. Further, we have carried out a phylogenetic analysis of all of the available African partial N gene and F gene PPRV sequences to investigate the epidemiology of PPRV with a focus on the emergence of different lineages of PPRV in Africa.