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End-resection at DNA double-strand breaks in the three domains of life

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<mark>Journal publication date</mark>1/02/2013
<mark>Journal</mark>Biochemical Society Transactions
Issue number1
Volume41
Number of pages7
Pages (from-to)314-320
Publication StatusPublished
<mark>Original language</mark>English

Abstract

During DNA repair by HR (homologous recombination), the ends of a DNA DSB (double-strand break) must be resected to generate single-stranded tails, which are required for strand invasion and exchange with homologous chromosomes. This 5'-3' end-resection of the DNA duplex is an essential process, conserved across all three domains of life: the bacteria, eukaryota and archaea. In the present review, we examine the numerous and redundant helicase and nuclease systems that function as the enzymatic analogues for this crucial process in the three major phylogenetic divisions.