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Energy Dynamics in the Brain: Contributions of Astrocytes to Metabolism and pH Homeostasis.

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Energy Dynamics in the Brain: Contributions of Astrocytes to Metabolism and pH Homeostasis. / Deitmer, JW; Theparambil, SM; Ruminot, I et al.
In: Frontiers in Neuroscience, Vol. 13, 1301, 06.12.2019.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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Deitmer JW, Theparambil SM, Ruminot I, Noor SI, Becker H. Energy Dynamics in the Brain: Contributions of Astrocytes to Metabolism and pH Homeostasis. Frontiers in Neuroscience. 2019 Dec 6;13:1301. doi: 10.3389/fnins.2019.01301

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Deitmer, JW ; Theparambil, SM ; Ruminot, I et al. / Energy Dynamics in the Brain: Contributions of Astrocytes to Metabolism and pH Homeostasis. In: Frontiers in Neuroscience. 2019 ; Vol. 13.

Bibtex

@article{bcc437b67a65405a921ddab9e7f7a2aa,
title = "Energy Dynamics in the Brain: Contributions of Astrocytes to Metabolism and pH Homeostasis.",
abstract = "Regulation of metabolism is complex and involves enzymes and membrane transporters, which form networks to support energy dynamics. Lactate, as a metabolic intermediate from glucose or glycogen breakdown, appears to play a major role as additional energetic substrate, which is shuttled between glycolytic and oxidative cells, both under hypoxic and normoxic conditions. Transport of lactate across the cell membrane is mediated by monocarboxylate transporters (MCTs) in cotransport with H+, which is a substrate, a signal and a modulator of metabolic processes. MCTs form a {"}transport metabolon{"} with carbonic anhydrases (CAs), which not only provide a rapid equilibrium between CO2, HCO3 - and H+, but, in addition, enhances lactate transport, as found in Xenopus oocytes, employed as heterologous expression system, as well as in astrocytes and cancer cells. Functional interactions between different CA isoforms and MCTs have been found to be isoform-specific, independent of the enzyme's catalytic activity, and they require physical interaction between the proteins. CAs mediate between different states of metabolic acidosis, induced by glycolysis and oxidative phosphorylation, and play a relay function in coupling pH regulation and metabolism. In the brain, metabolic processes in astrocytes appear to be linked to bicarbonate transport and to neuronal activity. Here, we focus on physiological processes of energy dynamics in astrocytes as well as on the transfer of energetic substrates to neurons.",
author = "JW Deitmer and SM Theparambil and I Ruminot and SI Noor and Holger Becker",
year = "2019",
month = dec,
day = "6",
doi = "10.3389/fnins.2019.01301",
language = "English",
volume = "13",
journal = "Frontiers in Neuroscience",
issn = "1662-453X",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Energy Dynamics in the Brain: Contributions of Astrocytes to Metabolism and pH Homeostasis.

AU - Deitmer, JW

AU - Theparambil, SM

AU - Ruminot, I

AU - Noor, SI

AU - Becker, Holger

PY - 2019/12/6

Y1 - 2019/12/6

N2 - Regulation of metabolism is complex and involves enzymes and membrane transporters, which form networks to support energy dynamics. Lactate, as a metabolic intermediate from glucose or glycogen breakdown, appears to play a major role as additional energetic substrate, which is shuttled between glycolytic and oxidative cells, both under hypoxic and normoxic conditions. Transport of lactate across the cell membrane is mediated by monocarboxylate transporters (MCTs) in cotransport with H+, which is a substrate, a signal and a modulator of metabolic processes. MCTs form a "transport metabolon" with carbonic anhydrases (CAs), which not only provide a rapid equilibrium between CO2, HCO3 - and H+, but, in addition, enhances lactate transport, as found in Xenopus oocytes, employed as heterologous expression system, as well as in astrocytes and cancer cells. Functional interactions between different CA isoforms and MCTs have been found to be isoform-specific, independent of the enzyme's catalytic activity, and they require physical interaction between the proteins. CAs mediate between different states of metabolic acidosis, induced by glycolysis and oxidative phosphorylation, and play a relay function in coupling pH regulation and metabolism. In the brain, metabolic processes in astrocytes appear to be linked to bicarbonate transport and to neuronal activity. Here, we focus on physiological processes of energy dynamics in astrocytes as well as on the transfer of energetic substrates to neurons.

AB - Regulation of metabolism is complex and involves enzymes and membrane transporters, which form networks to support energy dynamics. Lactate, as a metabolic intermediate from glucose or glycogen breakdown, appears to play a major role as additional energetic substrate, which is shuttled between glycolytic and oxidative cells, both under hypoxic and normoxic conditions. Transport of lactate across the cell membrane is mediated by monocarboxylate transporters (MCTs) in cotransport with H+, which is a substrate, a signal and a modulator of metabolic processes. MCTs form a "transport metabolon" with carbonic anhydrases (CAs), which not only provide a rapid equilibrium between CO2, HCO3 - and H+, but, in addition, enhances lactate transport, as found in Xenopus oocytes, employed as heterologous expression system, as well as in astrocytes and cancer cells. Functional interactions between different CA isoforms and MCTs have been found to be isoform-specific, independent of the enzyme's catalytic activity, and they require physical interaction between the proteins. CAs mediate between different states of metabolic acidosis, induced by glycolysis and oxidative phosphorylation, and play a relay function in coupling pH regulation and metabolism. In the brain, metabolic processes in astrocytes appear to be linked to bicarbonate transport and to neuronal activity. Here, we focus on physiological processes of energy dynamics in astrocytes as well as on the transfer of energetic substrates to neurons.

U2 - 10.3389/fnins.2019.01301

DO - 10.3389/fnins.2019.01301

M3 - Journal article

C2 - 31866811

VL - 13

JO - Frontiers in Neuroscience

JF - Frontiers in Neuroscience

SN - 1662-453X

M1 - 1301

ER -