The Covid pandemic has exerted unprecedented damage to economies globally. This chapter recognises that the COVID-19 pandemic threatened African entrepreneurial activities with resultant social problems. The chapter further documents the relatively understudied aspect of the socio-psychological effects of Covid-19 on entrepreneurship within the African context, focusing on the experience of Nigerian entrepreneurs. The chapter highlights the interplay between the economic, social, and psychological aspects of entrepreneurship. Theoretically, the social and psychological impacts of the pandemic on entrepreneurship are explored under the critical lens of the socio-psychological theory buttressing the role of the society and institutions in shaping the entrepreneurial context. The chapter concludes that African entrepreneurs must possess vital skills to survive in a fast-paced, changing, and increasingly uncertain society. Recommendations are offered on the critical roles of entrepreneurial- and government-based initiatives in mitigating the challenges faced by entrepreneurs in pandemics and other national emergencies. To inspire knowledge development in this domain, future research directions have been flagged.