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Epidemiological and Genetic Insights of the Circulating Foot-and-Mouth Disease Virus Serotypes in Egypt

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Epidemiological and Genetic Insights of the Circulating Foot-and-Mouth Disease Virus Serotypes in Egypt. / Hassanein, Rabab T.; Abdelmegeed, Hala K.; Abdelwahed, Dina A. et al.
In: Current Microbiology, Vol. 81, 435, 30.10.2024.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Hassanein, RT, Abdelmegeed, HK, Abdelwahed, DA, Zaki, AG, Saad, AS, Shahein, MA, Afify, AF & Rohaim, MA 2024, 'Epidemiological and Genetic Insights of the Circulating Foot-and-Mouth Disease Virus Serotypes in Egypt', Current Microbiology, vol. 81, 435. https://doi.org/10.1007/s00284-024-03944-x

APA

Hassanein, R. T., Abdelmegeed, H. K., Abdelwahed, D. A., Zaki, A. G., Saad, A. S., Shahein, M. A., Afify, A. F., & Rohaim, M. A. (2024). Epidemiological and Genetic Insights of the Circulating Foot-and-Mouth Disease Virus Serotypes in Egypt. Current Microbiology, 81, Article 435. https://doi.org/10.1007/s00284-024-03944-x

Vancouver

Hassanein RT, Abdelmegeed HK, Abdelwahed DA, Zaki AG, Saad AS, Shahein MA et al. Epidemiological and Genetic Insights of the Circulating Foot-and-Mouth Disease Virus Serotypes in Egypt. Current Microbiology. 2024 Oct 30;81:435. doi: 10.1007/s00284-024-03944-x

Author

Hassanein, Rabab T. ; Abdelmegeed, Hala K. ; Abdelwahed, Dina A. et al. / Epidemiological and Genetic Insights of the Circulating Foot-and-Mouth Disease Virus Serotypes in Egypt. In: Current Microbiology. 2024 ; Vol. 81.

Bibtex

@article{efb40194c38c41ff93613c9f56fff72b,
title = "Epidemiological and Genetic Insights of the Circulating Foot-and-Mouth Disease Virus Serotypes in Egypt",
abstract = "Foot-and-mouth disease virus (FMDV) remains a major threat to livestock in Egypt, with ongoing outbreaks involving serotypes A, O, and SAT2. This study aimed to improve the understanding of these circulating FMDV strains to improve control measures. Between 2022 and 2023, 134 cattle samples from across Egypt were analyzed, revealing a 67.9% positivity rate for Pan FMDV. Of these positive samples, 64 were identified as serotype A and 27 as serotype O. Genetic analysis indicated that serotype O strains clustered within the EA-3 topotype, suggesting endemic persistence and potential vaccine evasion, while serotype A strains were associated with the African topotype and linked to regions such as Ethiopia, Kenya, and Sudan. Notable amino acid mutations in the VP1 protein of both serotypes highlighted potential challenges to vaccine effectiveness. These findings underscore the need for enhanced surveillance, timely vaccine updates, and regional cooperation to effectively manage FMD outbreaks in Egypt and neighboring countries.",
author = "Hassanein, {Rabab T.} and Abdelmegeed, {Hala K.} and Abdelwahed, {Dina A.} and Zaki, {Abeer G.} and Saad, {Alaa S.} and Shahein, {Momtaz A.} and Afify, {Ahmed F.} and Rohaim, {Mohammed A.}",
year = "2024",
month = oct,
day = "30",
doi = "10.1007/s00284-024-03944-x",
language = "English",
volume = "81",
journal = "Current Microbiology",

}

RIS

TY - JOUR

T1 - Epidemiological and Genetic Insights of the Circulating Foot-and-Mouth Disease Virus Serotypes in Egypt

AU - Hassanein, Rabab T.

AU - Abdelmegeed, Hala K.

AU - Abdelwahed, Dina A.

AU - Zaki, Abeer G.

AU - Saad, Alaa S.

AU - Shahein, Momtaz A.

AU - Afify, Ahmed F.

AU - Rohaim, Mohammed A.

PY - 2024/10/30

Y1 - 2024/10/30

N2 - Foot-and-mouth disease virus (FMDV) remains a major threat to livestock in Egypt, with ongoing outbreaks involving serotypes A, O, and SAT2. This study aimed to improve the understanding of these circulating FMDV strains to improve control measures. Between 2022 and 2023, 134 cattle samples from across Egypt were analyzed, revealing a 67.9% positivity rate for Pan FMDV. Of these positive samples, 64 were identified as serotype A and 27 as serotype O. Genetic analysis indicated that serotype O strains clustered within the EA-3 topotype, suggesting endemic persistence and potential vaccine evasion, while serotype A strains were associated with the African topotype and linked to regions such as Ethiopia, Kenya, and Sudan. Notable amino acid mutations in the VP1 protein of both serotypes highlighted potential challenges to vaccine effectiveness. These findings underscore the need for enhanced surveillance, timely vaccine updates, and regional cooperation to effectively manage FMD outbreaks in Egypt and neighboring countries.

AB - Foot-and-mouth disease virus (FMDV) remains a major threat to livestock in Egypt, with ongoing outbreaks involving serotypes A, O, and SAT2. This study aimed to improve the understanding of these circulating FMDV strains to improve control measures. Between 2022 and 2023, 134 cattle samples from across Egypt were analyzed, revealing a 67.9% positivity rate for Pan FMDV. Of these positive samples, 64 were identified as serotype A and 27 as serotype O. Genetic analysis indicated that serotype O strains clustered within the EA-3 topotype, suggesting endemic persistence and potential vaccine evasion, while serotype A strains were associated with the African topotype and linked to regions such as Ethiopia, Kenya, and Sudan. Notable amino acid mutations in the VP1 protein of both serotypes highlighted potential challenges to vaccine effectiveness. These findings underscore the need for enhanced surveillance, timely vaccine updates, and regional cooperation to effectively manage FMD outbreaks in Egypt and neighboring countries.

U2 - 10.1007/s00284-024-03944-x

DO - 10.1007/s00284-024-03944-x

M3 - Journal article

VL - 81

JO - Current Microbiology

JF - Current Microbiology

M1 - 435

ER -