Home > Research > Publications & Outputs > Epidemiology of Human Seasonal Coronaviruses Am...

Research

Text available via DOI:

Keywords

View graph of relations

Epidemiology of Human Seasonal Coronaviruses Among People With Mild and Severe Acute Respiratory Illness in Blantyre, Malawi, 2011-2017

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

Epidemiology of Human Seasonal Coronaviruses Among People With Mild and Severe Acute Respiratory Illness in Blantyre, Malawi, 2011-2017. / Kovacs, Dory; Mambule, Ivan; Read, Jonathan M et al.
In: The Journal of infectious diseases, Vol. 230, No. 2, 16.08.2024, p. e363-e373.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Kovacs, D, Mambule, I, Read, JM, Kiran, A, Chilombe, M, Bvumbwe, T, Aston, S, Menyere, M, Masina, M, Kamzati, M, Ganiza, TN, Iuliano, D, McMorrow, M, Bar-Zeev, N, Everett, D, French, N & Ho, A 2024, 'Epidemiology of Human Seasonal Coronaviruses Among People With Mild and Severe Acute Respiratory Illness in Blantyre, Malawi, 2011-2017', The Journal of infectious diseases, vol. 230, no. 2, pp. e363-e373. https://doi.org/10.1093/infdis/jiad587

APA

Kovacs, D., Mambule, I., Read, J. M., Kiran, A., Chilombe, M., Bvumbwe, T., Aston, S., Menyere, M., Masina, M., Kamzati, M., Ganiza, T. N., Iuliano, D., McMorrow, M., Bar-Zeev, N., Everett, D., French, N., & Ho, A. (2024). Epidemiology of Human Seasonal Coronaviruses Among People With Mild and Severe Acute Respiratory Illness in Blantyre, Malawi, 2011-2017. The Journal of infectious diseases, 230(2), e363-e373. https://doi.org/10.1093/infdis/jiad587

Vancouver

Kovacs D, Mambule I, Read JM, Kiran A, Chilombe M, Bvumbwe T et al. Epidemiology of Human Seasonal Coronaviruses Among People With Mild and Severe Acute Respiratory Illness in Blantyre, Malawi, 2011-2017. The Journal of infectious diseases. 2024 Aug 16;230(2):e363-e373. Epub 2024 Feb 14. doi: 10.1093/infdis/jiad587

Author

Kovacs, Dory ; Mambule, Ivan ; Read, Jonathan M et al. / Epidemiology of Human Seasonal Coronaviruses Among People With Mild and Severe Acute Respiratory Illness in Blantyre, Malawi, 2011-2017. In: The Journal of infectious diseases. 2024 ; Vol. 230, No. 2. pp. e363-e373.

Bibtex

@article{6a4b4d07bdec43288eb2941a6b07a0c4,
title = "Epidemiology of Human Seasonal Coronaviruses Among People With Mild and Severe Acute Respiratory Illness in Blantyre, Malawi, 2011-2017",
abstract = "Background The aim of this study was to characterize the epidemiology of human seasonal coronaviruses (HCoVs) in southern Malawi. Methods We tested for HCoVs 229E, OC43, NL63, and HKU1 using real-time polymerase chain reaction (PCR) on upper respiratory specimens from asymptomatic controls and individuals of all ages recruited through severe acute respiratory illness (SARI) surveillance at Queen Elizabeth Central Hospital, Blantyre, and a prospective influenza-like illness (ILI) observational study between 2011 and 2017. We modeled the probability of having a positive PCR for each HCoV using negative binomial models, and calculated pathogen-attributable fractions (PAFs). Results Overall, 8.8% (539/6107) of specimens were positive for ≥1 HCoV. OC43 was the most frequently detected HCoV (3.1% [191/6107]). NL63 was more frequently detected in ILI patients (adjusted incidence rate ratio [aIRR], 9.60 [95% confidence interval {CI}, 3.25–28.30]), while 229E (aIRR, 8.99 [95% CI, 1.81–44.70]) was more frequent in SARI patients than asymptomatic controls. In adults, 229E and OC43 were associated with SARI (PAF, 86.5% and 89.4%, respectively), while NL63 was associated with ILI (PAF, 85.1%). The prevalence of HCoVs was similar between children with SARI and controls. All HCoVs had bimodal peaks but distinct seasonality. Conclusions OC43 was the most prevalent HCoV in acute respiratory illness of all ages. Individual HCoVs had distinct seasonality that differed from temperate settings.",
keywords = "Adolescent, Adult, Aged, Child, Child, Preschool, Coronavirus Infections/epidemiology, Coronavirus/genetics, Female, Humans, Infant, Infant, Newborn, Malawi/epidemiology, Male, Middle Aged, Prospective Studies, Respiratory Tract Infections/epidemiology, Seasons, Young Adult",
author = "Dory Kovacs and Ivan Mambule and Read, {Jonathan M} and Anmol Kiran and Moses Chilombe and Thandiwe Bvumbwe and Stephen Aston and Mavis Menyere and Mazuba Masina and Moses Kamzati and Ganiza, {Thokozani Namale} and Danielle Iuliano and Meredith McMorrow and Naor Bar-Zeev and Dean Everett and Neil French and Antonia Ho",
year = "2024",
month = aug,
day = "16",
doi = "10.1093/infdis/jiad587",
language = "English",
volume = "230",
pages = "e363--e373",
journal = "The Journal of infectious diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Epidemiology of Human Seasonal Coronaviruses Among People With Mild and Severe Acute Respiratory Illness in Blantyre, Malawi, 2011-2017

AU - Kovacs, Dory

AU - Mambule, Ivan

AU - Read, Jonathan M

AU - Kiran, Anmol

AU - Chilombe, Moses

AU - Bvumbwe, Thandiwe

AU - Aston, Stephen

AU - Menyere, Mavis

AU - Masina, Mazuba

AU - Kamzati, Moses

AU - Ganiza, Thokozani Namale

AU - Iuliano, Danielle

AU - McMorrow, Meredith

AU - Bar-Zeev, Naor

AU - Everett, Dean

AU - French, Neil

AU - Ho, Antonia

PY - 2024/8/16

Y1 - 2024/8/16

N2 - Background The aim of this study was to characterize the epidemiology of human seasonal coronaviruses (HCoVs) in southern Malawi. Methods We tested for HCoVs 229E, OC43, NL63, and HKU1 using real-time polymerase chain reaction (PCR) on upper respiratory specimens from asymptomatic controls and individuals of all ages recruited through severe acute respiratory illness (SARI) surveillance at Queen Elizabeth Central Hospital, Blantyre, and a prospective influenza-like illness (ILI) observational study between 2011 and 2017. We modeled the probability of having a positive PCR for each HCoV using negative binomial models, and calculated pathogen-attributable fractions (PAFs). Results Overall, 8.8% (539/6107) of specimens were positive for ≥1 HCoV. OC43 was the most frequently detected HCoV (3.1% [191/6107]). NL63 was more frequently detected in ILI patients (adjusted incidence rate ratio [aIRR], 9.60 [95% confidence interval {CI}, 3.25–28.30]), while 229E (aIRR, 8.99 [95% CI, 1.81–44.70]) was more frequent in SARI patients than asymptomatic controls. In adults, 229E and OC43 were associated with SARI (PAF, 86.5% and 89.4%, respectively), while NL63 was associated with ILI (PAF, 85.1%). The prevalence of HCoVs was similar between children with SARI and controls. All HCoVs had bimodal peaks but distinct seasonality. Conclusions OC43 was the most prevalent HCoV in acute respiratory illness of all ages. Individual HCoVs had distinct seasonality that differed from temperate settings.

AB - Background The aim of this study was to characterize the epidemiology of human seasonal coronaviruses (HCoVs) in southern Malawi. Methods We tested for HCoVs 229E, OC43, NL63, and HKU1 using real-time polymerase chain reaction (PCR) on upper respiratory specimens from asymptomatic controls and individuals of all ages recruited through severe acute respiratory illness (SARI) surveillance at Queen Elizabeth Central Hospital, Blantyre, and a prospective influenza-like illness (ILI) observational study between 2011 and 2017. We modeled the probability of having a positive PCR for each HCoV using negative binomial models, and calculated pathogen-attributable fractions (PAFs). Results Overall, 8.8% (539/6107) of specimens were positive for ≥1 HCoV. OC43 was the most frequently detected HCoV (3.1% [191/6107]). NL63 was more frequently detected in ILI patients (adjusted incidence rate ratio [aIRR], 9.60 [95% confidence interval {CI}, 3.25–28.30]), while 229E (aIRR, 8.99 [95% CI, 1.81–44.70]) was more frequent in SARI patients than asymptomatic controls. In adults, 229E and OC43 were associated with SARI (PAF, 86.5% and 89.4%, respectively), while NL63 was associated with ILI (PAF, 85.1%). The prevalence of HCoVs was similar between children with SARI and controls. All HCoVs had bimodal peaks but distinct seasonality. Conclusions OC43 was the most prevalent HCoV in acute respiratory illness of all ages. Individual HCoVs had distinct seasonality that differed from temperate settings.

KW - Adolescent

KW - Adult

KW - Aged

KW - Child

KW - Child, Preschool

KW - Coronavirus Infections/epidemiology

KW - Coronavirus/genetics

KW - Female

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Malawi/epidemiology

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - Respiratory Tract Infections/epidemiology

KW - Seasons

KW - Young Adult

U2 - 10.1093/infdis/jiad587

DO - 10.1093/infdis/jiad587

M3 - Journal article

C2 - 38365443

VL - 230

SP - e363-e373

JO - The Journal of infectious diseases

JF - The Journal of infectious diseases

SN - 0022-1899

IS - 2

ER -