Home > Research > Publications & Outputs > Epstein-Barr virus isolates retain their capaci...

Links

Text available via DOI:

View graph of relations

Epstein-Barr virus isolates retain their capacity to evade T cell immunity through BNLF2a despite extensive sequence variation

Research output: Contribution to journalJournal articlepeer-review

Published
  • Daniëlle Horst
  • Scott R. Burrows
  • Derek Gatherer
  • Bonnie van Wilgenburg
  • Ingrid G. J. Boer
  • Melissa J. Bell
  • Maaike E. Ressing
  • Emmanuel J. H. J. Wiertz
Close
<mark>Journal publication date</mark>01/2012
<mark>Journal</mark>Journal of Virology
Issue number1
Volume86
Number of pages6
Pages (from-to)572-577
Publication StatusPublished
<mark>Original language</mark>English

Abstract

The Epstein-Barr virus (EBV)-encoded immune evasion protein BNLF2a inhibits the transporter associated with antigen processing (TAP), thereby downregulating HLA class I expression at the cell surface. As a consequence, recognition of EBV-infected cells by cytotoxic T cells is impaired. Here, we show that sequence polymorphism of the BNLF2a protein is observed with natural EBV isolates, with evidence for positive selection. Despite these mutations, the BNLF2a variants efficiently reduce cell surface HLA class I levels. This conservation of BNLF2a function during evolution of EBV implies an important role for the viral TAP inhibitor in preventing T cell recognition during viral infection.