Final published version
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter
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TY - CHAP
T1 - Estimation of evolutionary dynamics and selection pressure in coronaviruses
AU - Munir, Muhammad
AU - Cortey, Martí
PY - 2015/2/26
Y1 - 2015/2/26
N2 - Evolution of coronaviruses is facilitated by the strong selection, large population size, and great genetic diversity within the susceptible hosts. This predisposition is primarily due to high error rate, and limited proofreading capability of the viral polymerase and by recombination. These characteristics make coronaviruses an interesting model system to study the mechanisms involved in viral evolution and the ways viruses adapt to switch host or to gain novel functions. Here we describe the protocol to estimate selection pressures for the spike gene and evolutionary dynamics of bovine coronaviruses.
AB - Evolution of coronaviruses is facilitated by the strong selection, large population size, and great genetic diversity within the susceptible hosts. This predisposition is primarily due to high error rate, and limited proofreading capability of the viral polymerase and by recombination. These characteristics make coronaviruses an interesting model system to study the mechanisms involved in viral evolution and the ways viruses adapt to switch host or to gain novel functions. Here we describe the protocol to estimate selection pressures for the spike gene and evolutionary dynamics of bovine coronaviruses.
KW - Coronaviruses
KW - Emergence
KW - Evolution
KW - Genetics
KW - S gene
KW - Selection
U2 - 10.1007/978-1-4939-2438-7_4
DO - 10.1007/978-1-4939-2438-7_4
M3 - Chapter
C2 - 25720469
AN - SCOPUS:84954604697
SN - 9781493924370
SP - 41
EP - 48
BT - Coronaviruses
PB - Springer New York LLC
ER -