Research output: Contribution to Journal/Magazine › Journal article
Research output: Contribution to Journal/Magazine › Journal article
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TY - JOUR
T1 - Estimation of Spatial Variation in Risk Using Matched Case-control Data.
AU - Jarner, Mikala F.
AU - Diggle, Peter J.
AU - Chetwynd, Amanda G.
PY - 2002/12
Y1 - 2002/12
N2 - A common problem in environmental epidemiology is to estimate spatial variation in disease risk after accounting for known risk factors. In this paper we consider this problem in the context of matched case-control studies. We extend the generalised additive model approach of Kelsall and Diggle (1998) to studies in which each case has been individually matched to a set of controls. We discuss a method for fitting this model to data, apply the method to a matched study on perinatal death in the North West Thames region of England and explain why, if spatial variation is of particular scientific interest, matching is undesirable.
AB - A common problem in environmental epidemiology is to estimate spatial variation in disease risk after accounting for known risk factors. In this paper we consider this problem in the context of matched case-control studies. We extend the generalised additive model approach of Kelsall and Diggle (1998) to studies in which each case has been individually matched to a set of controls. We discuss a method for fitting this model to data, apply the method to a matched study on perinatal death in the North West Thames region of England and explain why, if spatial variation is of particular scientific interest, matching is undesirable.
KW - Spatial variation in risk • Generalised additive models • Epidemiology • Matched case-control design
U2 - 10.1002/bimj.200290005
DO - 10.1002/bimj.200290005
M3 - Journal article
VL - 44
SP - 936
EP - 945
JO - Biometrical Journal
JF - Biometrical Journal
SN - 1521-4036
IS - 8
ER -