The aim of this study was to evaluate the viricidal action of fourteen commonly used and commercially available disinfectants on poultry farms and are belonging to different groups of biocides against Velogenic Newcastle disease virus (NDV). Evaluation was carried on two different surfaces (cement and rubber) contaminated experimentally with Newcastle disease virus. Reliable disinfectants should pass the test if at least 2.8 log reductions were achieved, and no recoverable viruses were isolated after the treatment, the last point is very important in the evaluation as although the direct reduction in virus titer is critically needed in terminal disinfection, the recovered virus after disinfection or shed virus after vaccination will be always capable of introducing infections. Our results revealed that three disinfectants out of fourteen were able to achieve the previous test criteria 1. Calcium hypochlorite (5.5 log reduction on cement coupons, and 4.38 on rubber coupons) 2. Halamid ® (5.5 log reduction on cement coupons, and 4.38 on rubber coupons) and 3. ZixVirox ® (5.5 log reduction on cement coupons, and 4.38 on rubber coupons) while Virkon S ® , PIQuat 20 ® , Synergize ® +Formalin, and GroundZero ® had only achieved the required log reduction on both surfaces but failed to stop viral propagation, it’s also worth to mention that disinfectants Aquazix E52 ® and FumagriEffisafe ® achieved the required log reduction on cement surface only but also failed to stop viral replication, disinfectants Synergize ® , Formic, and Citric acid neither achieved the required log reduction on both surfaces, nor stopped the virus propagation after treatment. © 2017 @ author (s).