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Evidence for a role of Anopheles stephensi in the spread of drug and diagnosis-resistant malaria in Africa

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Evidence for a role of Anopheles stephensi in the spread of drug and diagnosis-resistant malaria in Africa. / Emiru, Tadele; Getachew, Dejene; Murphy, Maxwell et al.
In: Nature Medicine, 26.10.2023.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Emiru, T, Getachew, D, Murphy, M, Sedda, L, Ejigu, LA, Bulto, MG, Byrne, I, Demisse, M, Abdo, M, Chali, W, Elliott, A, Vickers, EN, Aranda-Díaz, A, Alemayehu, L, Behaksera, SW, Jebessa, G, Dinka, H, Tsegaye, T, Teka, H, Chibsa, S, Mumba, P, Girma, S, Hwang, J, Yoshimizu, M, Sutcliffe, A, Taffese, HS, Bayissa, GA, Zohdy, S, Tongren, JE, Drakeley, C, Greenhouse, B, Bousema, T & Tadesse, FG 2023, 'Evidence for a role of Anopheles stephensi in the spread of drug and diagnosis-resistant malaria in Africa', Nature Medicine. https://doi.org/10.1038/s41591-023-02641-9

APA

Emiru, T., Getachew, D., Murphy, M., Sedda, L., Ejigu, L. A., Bulto, M. G., Byrne, I., Demisse, M., Abdo, M., Chali, W., Elliott, A., Vickers, E. N., Aranda-Díaz, A., Alemayehu, L., Behaksera, S. W., Jebessa, G., Dinka, H., Tsegaye, T., Teka, H., ... Tadesse, F. G. (2023). Evidence for a role of Anopheles stephensi in the spread of drug and diagnosis-resistant malaria in Africa. Nature Medicine. Advance online publication. https://doi.org/10.1038/s41591-023-02641-9

Vancouver

Emiru T, Getachew D, Murphy M, Sedda L, Ejigu LA, Bulto MG et al. Evidence for a role of Anopheles stephensi in the spread of drug and diagnosis-resistant malaria in Africa. Nature Medicine. 2023 Oct 26. Epub 2023 Oct 26. doi: 10.1038/s41591-023-02641-9

Author

Emiru, Tadele ; Getachew, Dejene ; Murphy, Maxwell et al. / Evidence for a role of Anopheles stephensi in the spread of drug and diagnosis-resistant malaria in Africa. In: Nature Medicine. 2023.

Bibtex

@article{2c44335de570474b81962e3c6672ea7a,
title = "Evidence for a role of Anopheles stephensi in the spread of drug and diagnosis-resistant malaria in Africa",
abstract = "Anopheles stephensi, an Asian malaria vector, continues to expand across Africa. The vector is now firmly established in urban settings in the Horn of Africa. Its presence in areas where malaria resurged suggested a possible role in causing malaria outbreaks. Using a prospective case control design, we investigated the role of An. stephensi in transmission following a malaria outbreak in Dire Dawa, Ethiopia in April-July 2022. Screening contacts of malaria patients and febrile controls revealed spatial clustering of P. falciparum infections around malaria patients in strong association with An. stephensi presence in the household vicinity. Plasmodium sporozoites were detected in these mosquitoes. This outbreak involved clonal propagation of parasites with molecular signatures of artemisinin and diagnostic resistance. This study provides the strongest evidence to date for a role of An. stephensi in driving an urban malaria outbreak in Africa, highlighting the major public health threat this fast-spreading mosquito poses.",
author = "Tadele Emiru and Dejene Getachew and Maxwell Murphy and Luigi Sedda and Ejigu, {Legesse Alamerie} and Bulto, {Mikiyas Gebremichael} and Isabel Byrne and Mulugeta Demisse and Melat Abdo and Wakweya Chali and Aaron Elliott and Vickers, {Eric Neubauer} and Andr{\'e}s Aranda-D{\'i}az and Lina Alemayehu and Behaksera, {Sinknesh W.} and Gutema Jebessa and Hunduma Dinka and Tizita Tsegaye and Hiwot Teka and Sheleme Chibsa and Peter Mumba and Samuel Girma and Jimee Hwang and Melissa Yoshimizu and Alice Sutcliffe and Taffese, {Hiwot Solomon} and Bayissa, {Gudissa Aseffa} and Sarah Zohdy and Tongren, {Jon Eric} and Chris Drakeley and Bryan Greenhouse and Teun Bousema and Tadesse, {Fitsum G.}",
year = "2023",
month = oct,
day = "26",
doi = "10.1038/s41591-023-02641-9",
language = "English",
journal = "Nature Medicine",
issn = "1078-8956",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Evidence for a role of Anopheles stephensi in the spread of drug and diagnosis-resistant malaria in Africa

AU - Emiru, Tadele

AU - Getachew, Dejene

AU - Murphy, Maxwell

AU - Sedda, Luigi

AU - Ejigu, Legesse Alamerie

AU - Bulto, Mikiyas Gebremichael

AU - Byrne, Isabel

AU - Demisse, Mulugeta

AU - Abdo, Melat

AU - Chali, Wakweya

AU - Elliott, Aaron

AU - Vickers, Eric Neubauer

AU - Aranda-Díaz, Andrés

AU - Alemayehu, Lina

AU - Behaksera, Sinknesh W.

AU - Jebessa, Gutema

AU - Dinka, Hunduma

AU - Tsegaye, Tizita

AU - Teka, Hiwot

AU - Chibsa, Sheleme

AU - Mumba, Peter

AU - Girma, Samuel

AU - Hwang, Jimee

AU - Yoshimizu, Melissa

AU - Sutcliffe, Alice

AU - Taffese, Hiwot Solomon

AU - Bayissa, Gudissa Aseffa

AU - Zohdy, Sarah

AU - Tongren, Jon Eric

AU - Drakeley, Chris

AU - Greenhouse, Bryan

AU - Bousema, Teun

AU - Tadesse, Fitsum G.

PY - 2023/10/26

Y1 - 2023/10/26

N2 - Anopheles stephensi, an Asian malaria vector, continues to expand across Africa. The vector is now firmly established in urban settings in the Horn of Africa. Its presence in areas where malaria resurged suggested a possible role in causing malaria outbreaks. Using a prospective case control design, we investigated the role of An. stephensi in transmission following a malaria outbreak in Dire Dawa, Ethiopia in April-July 2022. Screening contacts of malaria patients and febrile controls revealed spatial clustering of P. falciparum infections around malaria patients in strong association with An. stephensi presence in the household vicinity. Plasmodium sporozoites were detected in these mosquitoes. This outbreak involved clonal propagation of parasites with molecular signatures of artemisinin and diagnostic resistance. This study provides the strongest evidence to date for a role of An. stephensi in driving an urban malaria outbreak in Africa, highlighting the major public health threat this fast-spreading mosquito poses.

AB - Anopheles stephensi, an Asian malaria vector, continues to expand across Africa. The vector is now firmly established in urban settings in the Horn of Africa. Its presence in areas where malaria resurged suggested a possible role in causing malaria outbreaks. Using a prospective case control design, we investigated the role of An. stephensi in transmission following a malaria outbreak in Dire Dawa, Ethiopia in April-July 2022. Screening contacts of malaria patients and febrile controls revealed spatial clustering of P. falciparum infections around malaria patients in strong association with An. stephensi presence in the household vicinity. Plasmodium sporozoites were detected in these mosquitoes. This outbreak involved clonal propagation of parasites with molecular signatures of artemisinin and diagnostic resistance. This study provides the strongest evidence to date for a role of An. stephensi in driving an urban malaria outbreak in Africa, highlighting the major public health threat this fast-spreading mosquito poses.

U2 - 10.1038/s41591-023-02641-9

DO - 10.1038/s41591-023-02641-9

M3 - Journal article

JO - Nature Medicine

JF - Nature Medicine

SN - 1078-8956

ER -