T2K reports its first results in the search for CP violation in neutrino oscillations using appearance and disappearance channels for neutrino- and antineutrino-mode beam. The data include all runs from Jan 2010 to May 2016 and comprise $7.482\times10^{20}$,protons on target in neutrino mode, which yielded in the far detector 32 e-like and 135 $\mu$-like events, and $7.471\times10^{20}$,protons on target in antineutrino mode which yielded 4 e-like and 66 $\mu$-like events. Reactor measurements of $\sin^{2}2\theta_{13}$ have been used as an additional constraint. The one-dimensional confidence interval at 90% for $\delta_{CP}$ spans the range ($-3.13$, $-0.39$) for normal mass ordering. The CP conservation hypothesis ($\delta_{CP}=0,\pi$) is excluded at 90% C.L.