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From adversity to psychosis: pathways and mechanisms from specific adversities to specific symptoms

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From adversity to psychosis: pathways and mechanisms from specific adversities to specific symptoms. / Bentall, Richard P.; de Sousa, Paulo; Varese, Filippo et al.
In: Social Psychiatry and Psychiatric Epidemiology, Vol. 49, No. 7, 07.2014, p. 1011-1022.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Bentall, RP, de Sousa, P, Varese, F, Wickham, S, Sitko, K, Haarmans, M & Read, J 2014, 'From adversity to psychosis: pathways and mechanisms from specific adversities to specific symptoms', Social Psychiatry and Psychiatric Epidemiology, vol. 49, no. 7, pp. 1011-1022. https://doi.org/10.1007/s00127-014-0914-0

APA

Bentall, R. P., de Sousa, P., Varese, F., Wickham, S., Sitko, K., Haarmans, M., & Read, J. (2014). From adversity to psychosis: pathways and mechanisms from specific adversities to specific symptoms. Social Psychiatry and Psychiatric Epidemiology, 49(7), 1011-1022. https://doi.org/10.1007/s00127-014-0914-0

Vancouver

Bentall RP, de Sousa P, Varese F, Wickham S, Sitko K, Haarmans M et al. From adversity to psychosis: pathways and mechanisms from specific adversities to specific symptoms. Social Psychiatry and Psychiatric Epidemiology. 2014 Jul;49(7):1011-1022. doi: 10.1007/s00127-014-0914-0

Author

Bentall, Richard P. ; de Sousa, Paulo ; Varese, Filippo et al. / From adversity to psychosis : pathways and mechanisms from specific adversities to specific symptoms. In: Social Psychiatry and Psychiatric Epidemiology. 2014 ; Vol. 49, No. 7. pp. 1011-1022.

Bibtex

@article{e26aa0212364421c938fbca7528b3111,
title = "From adversity to psychosis: pathways and mechanisms from specific adversities to specific symptoms",
abstract = "PURPOSE: Although there is considerable evidence that adversities in childhood such as social deprivation, sexual abuse, separation from parents, neglect and exposure to deviant parental communication are associated with psychosis in later life, most studies have considered broad diagnoses as outcomes. In this review we consider evidence for pathways between specific types of adversity and specific symptoms of psychosis.METHODS: We present theoretical arguments for expecting some degree of specificity (although by no means perfect specificity) between different kinds of adversity and different symptoms of psychosis. We review studies that have investigated social-environmental risk factors for thought disorder, auditory-verbal hallucinations and paranoid delusions, and consider how these risk factors may impact on specific psychological and biological mechanisms.RESULTS: Communication deviance in parents has been implicated in the development of thought disorder in offspring, childhood sexual abuse has been particularly implicated in auditory-verbal hallucinations, and attachment-disrupting events (e.g. neglect, being brought up in an institution) may have particular potency for the development of paranoid symptoms. Current research on psychological mechanisms underlying these symptoms suggests a number of symptom-specific mechanisms that may explain these associations.CONCLUSIONS: Few studies have considered symptoms, underlying mechanisms and different kinds of adversity at the same time. Future research along these lines will have the potential to elucidate the mechanisms that lead to severe mental illness, and may have considerable clinical implications.",
keywords = "Childhood adversity , Psychosis, Paranoia , Thought disorder , Hallucinations",
author = "Bentall, {Richard P.} and {de Sousa}, Paulo and Filippo Varese and Sophie Wickham and Katarzyna Sitko and Maria Haarmans and John Read",
year = "2014",
month = jul,
doi = "10.1007/s00127-014-0914-0",
language = "English",
volume = "49",
pages = "1011--1022",
journal = "Social Psychiatry and Psychiatric Epidemiology",
issn = "0933-7954",
publisher = "D. Steinkopff-Verlag",
number = "7",

}

RIS

TY - JOUR

T1 - From adversity to psychosis

T2 - pathways and mechanisms from specific adversities to specific symptoms

AU - Bentall, Richard P.

AU - de Sousa, Paulo

AU - Varese, Filippo

AU - Wickham, Sophie

AU - Sitko, Katarzyna

AU - Haarmans, Maria

AU - Read, John

PY - 2014/7

Y1 - 2014/7

N2 - PURPOSE: Although there is considerable evidence that adversities in childhood such as social deprivation, sexual abuse, separation from parents, neglect and exposure to deviant parental communication are associated with psychosis in later life, most studies have considered broad diagnoses as outcomes. In this review we consider evidence for pathways between specific types of adversity and specific symptoms of psychosis.METHODS: We present theoretical arguments for expecting some degree of specificity (although by no means perfect specificity) between different kinds of adversity and different symptoms of psychosis. We review studies that have investigated social-environmental risk factors for thought disorder, auditory-verbal hallucinations and paranoid delusions, and consider how these risk factors may impact on specific psychological and biological mechanisms.RESULTS: Communication deviance in parents has been implicated in the development of thought disorder in offspring, childhood sexual abuse has been particularly implicated in auditory-verbal hallucinations, and attachment-disrupting events (e.g. neglect, being brought up in an institution) may have particular potency for the development of paranoid symptoms. Current research on psychological mechanisms underlying these symptoms suggests a number of symptom-specific mechanisms that may explain these associations.CONCLUSIONS: Few studies have considered symptoms, underlying mechanisms and different kinds of adversity at the same time. Future research along these lines will have the potential to elucidate the mechanisms that lead to severe mental illness, and may have considerable clinical implications.

AB - PURPOSE: Although there is considerable evidence that adversities in childhood such as social deprivation, sexual abuse, separation from parents, neglect and exposure to deviant parental communication are associated with psychosis in later life, most studies have considered broad diagnoses as outcomes. In this review we consider evidence for pathways between specific types of adversity and specific symptoms of psychosis.METHODS: We present theoretical arguments for expecting some degree of specificity (although by no means perfect specificity) between different kinds of adversity and different symptoms of psychosis. We review studies that have investigated social-environmental risk factors for thought disorder, auditory-verbal hallucinations and paranoid delusions, and consider how these risk factors may impact on specific psychological and biological mechanisms.RESULTS: Communication deviance in parents has been implicated in the development of thought disorder in offspring, childhood sexual abuse has been particularly implicated in auditory-verbal hallucinations, and attachment-disrupting events (e.g. neglect, being brought up in an institution) may have particular potency for the development of paranoid symptoms. Current research on psychological mechanisms underlying these symptoms suggests a number of symptom-specific mechanisms that may explain these associations.CONCLUSIONS: Few studies have considered symptoms, underlying mechanisms and different kinds of adversity at the same time. Future research along these lines will have the potential to elucidate the mechanisms that lead to severe mental illness, and may have considerable clinical implications.

KW - Childhood adversity

KW - Psychosis

KW - Paranoia

KW - Thought disorder

KW - Hallucinations

U2 - 10.1007/s00127-014-0914-0

DO - 10.1007/s00127-014-0914-0

M3 - Journal article

C2 - 24919446

VL - 49

SP - 1011

EP - 1022

JO - Social Psychiatry and Psychiatric Epidemiology

JF - Social Psychiatry and Psychiatric Epidemiology

SN - 0933-7954

IS - 7

ER -