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From Batch to Continuous: Freeze-Drying of Suspended Vials for Pharmaceuticals in Unit-Doses

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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From Batch to Continuous: Freeze-Drying of Suspended Vials for Pharmaceuticals in Unit-Doses. / Capozzi, Luigi C.; Trout, Bernhardt L.; Pisano, Roberto.
In: Industrial and Engineering Chemistry Research, Vol. 58, No. 4, 30.01.2019, p. 1635-1649.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Capozzi, LC, Trout, BL & Pisano, R 2019, 'From Batch to Continuous: Freeze-Drying of Suspended Vials for Pharmaceuticals in Unit-Doses', Industrial and Engineering Chemistry Research, vol. 58, no. 4, pp. 1635-1649. https://doi.org/10.1021/acs.iecr.8b02886

APA

Capozzi, L. C., Trout, B. L., & Pisano, R. (2019). From Batch to Continuous: Freeze-Drying of Suspended Vials for Pharmaceuticals in Unit-Doses. Industrial and Engineering Chemistry Research, 58(4), 1635-1649. https://doi.org/10.1021/acs.iecr.8b02886

Vancouver

Capozzi LC, Trout BL, Pisano R. From Batch to Continuous: Freeze-Drying of Suspended Vials for Pharmaceuticals in Unit-Doses. Industrial and Engineering Chemistry Research. 2019 Jan 30;58(4):1635-1649. doi: 10.1021/acs.iecr.8b02886

Author

Capozzi, Luigi C. ; Trout, Bernhardt L. ; Pisano, Roberto. / From Batch to Continuous : Freeze-Drying of Suspended Vials for Pharmaceuticals in Unit-Doses. In: Industrial and Engineering Chemistry Research. 2019 ; Vol. 58, No. 4. pp. 1635-1649.

Bibtex

@article{57a279d51e374d5db20a8096c7a5006b,
title = "From Batch to Continuous: Freeze-Drying of Suspended Vials for Pharmaceuticals in Unit-Doses",
abstract = "In response to the current trend in the pharmaceutical industry, a new concept for the freeze-drying of pharmaceuticals in unit-doses is presented: the continuous freeze-drying/lyophilization of suspended vials. This configuration makes it possible to set up a continuous freeze-drying process that produces a final product with similar characteristics to those traditionally obtained by means of the batch process but which avoids the drawbacks of conventional, batch freeze-drying. The feasibility and advantages of this new concept are presented in this work. Continuous freeze-drying has been found to improve heat transfer uniformity and reduce the primary drying duration by 2-4 times. As far as the structure of lyophilized products is concerned, SEM micrographs of the lyophilized samples showed that this technology improves vial-to-vial and intravial homogeneity.",
author = "Capozzi, {Luigi C.} and Trout, {Bernhardt L.} and Roberto Pisano",
year = "2019",
month = jan,
day = "30",
doi = "10.1021/acs.iecr.8b02886",
language = "English",
volume = "58",
pages = "1635--1649",
journal = "Industrial and Engineering Chemistry Research",
issn = "0888-5885",
publisher = "American Chemical Society",
number = "4",

}

RIS

TY - JOUR

T1 - From Batch to Continuous

T2 - Freeze-Drying of Suspended Vials for Pharmaceuticals in Unit-Doses

AU - Capozzi, Luigi C.

AU - Trout, Bernhardt L.

AU - Pisano, Roberto

PY - 2019/1/30

Y1 - 2019/1/30

N2 - In response to the current trend in the pharmaceutical industry, a new concept for the freeze-drying of pharmaceuticals in unit-doses is presented: the continuous freeze-drying/lyophilization of suspended vials. This configuration makes it possible to set up a continuous freeze-drying process that produces a final product with similar characteristics to those traditionally obtained by means of the batch process but which avoids the drawbacks of conventional, batch freeze-drying. The feasibility and advantages of this new concept are presented in this work. Continuous freeze-drying has been found to improve heat transfer uniformity and reduce the primary drying duration by 2-4 times. As far as the structure of lyophilized products is concerned, SEM micrographs of the lyophilized samples showed that this technology improves vial-to-vial and intravial homogeneity.

AB - In response to the current trend in the pharmaceutical industry, a new concept for the freeze-drying of pharmaceuticals in unit-doses is presented: the continuous freeze-drying/lyophilization of suspended vials. This configuration makes it possible to set up a continuous freeze-drying process that produces a final product with similar characteristics to those traditionally obtained by means of the batch process but which avoids the drawbacks of conventional, batch freeze-drying. The feasibility and advantages of this new concept are presented in this work. Continuous freeze-drying has been found to improve heat transfer uniformity and reduce the primary drying duration by 2-4 times. As far as the structure of lyophilized products is concerned, SEM micrographs of the lyophilized samples showed that this technology improves vial-to-vial and intravial homogeneity.

U2 - 10.1021/acs.iecr.8b02886

DO - 10.1021/acs.iecr.8b02886

M3 - Journal article

AN - SCOPUS:85060294738

VL - 58

SP - 1635

EP - 1649

JO - Industrial and Engineering Chemistry Research

JF - Industrial and Engineering Chemistry Research

SN - 0888-5885

IS - 4

ER -