Rights statement: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Environmental Science and Technology, copyright ©2015 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/10.1021/acs.est.5b02412
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Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - From bioavailability science to regulation of organic chemicals
AU - Ortega-Calvo, Jose-J.
AU - Harmsen, Joop
AU - Parsons, John R.
AU - Semple, Kirk T.
AU - Aitken, Michael D.
AU - Ajao, Charmaine
AU - Eadsforth, Charles
AU - Galay-Burgos, Malyka
AU - Naidu, Ravi
AU - Oliver, Robin
AU - Peijnenburg, Willie J. G. M.
AU - Roembke, Joerg
AU - Streck, Georg
AU - Versonnen, Bram
N1 - This document is the Accepted Manuscript version of a Published Work that appeared in final form in Environmental Science and Technology, copyright ©2015 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/10.1021/acs.est.5b02412
PY - 2015/9/1
Y1 - 2015/9/1
N2 - The bioavailability of organic chemicals in soil and sediment is an important area of scientific investigation for environmental scientists, although this area of study remains only partially recognized by regulators and industries working in the environmental sector. Regulators have recently started to consider bioavailability within retrospective risk assessment frameworks for organic chemicals; by doing so, realistic decision-making with regard to polluted environments can be achieved, rather than relying on the traditional approach of using total-extractable concentrations. However, implementation remains difficult because scientific developments on bioavailability are not always translated into ready-to-use approaches for regulators. Similarly, bioavailability remains largely unexplored within prospective regulatory frameworks that address the approval and regulation of organic chemicals. This article discusses bioavailability concepts and methods, as well as possible pathways for the implementation of bioavailability into risk assessment and regulation; in addition, this article offers a simple, pragmatic and justifiable approach for use within retrospective and prospective risk assessment.
AB - The bioavailability of organic chemicals in soil and sediment is an important area of scientific investigation for environmental scientists, although this area of study remains only partially recognized by regulators and industries working in the environmental sector. Regulators have recently started to consider bioavailability within retrospective risk assessment frameworks for organic chemicals; by doing so, realistic decision-making with regard to polluted environments can be achieved, rather than relying on the traditional approach of using total-extractable concentrations. However, implementation remains difficult because scientific developments on bioavailability are not always translated into ready-to-use approaches for regulators. Similarly, bioavailability remains largely unexplored within prospective regulatory frameworks that address the approval and regulation of organic chemicals. This article discusses bioavailability concepts and methods, as well as possible pathways for the implementation of bioavailability into risk assessment and regulation; in addition, this article offers a simple, pragmatic and justifiable approach for use within retrospective and prospective risk assessment.
KW - POLYCYCLIC AROMATIC-HYDROCARBONS
KW - DESORPTION-KINETICS
KW - CONTAMINATED SEDIMENTS
KW - MICROBIAL AVAILABILITY
KW - PAH BIOAVAILABILITY
KW - IN-SITU
KW - SOIL
KW - EXTRACTION
KW - BIODEGRADATION
KW - FRAMEWORK
U2 - 10.1021/acs.est.5b02412
DO - 10.1021/acs.est.5b02412
M3 - Journal article
VL - 49
SP - 10255
EP - 10264
JO - Environmental Science and Technology
JF - Environmental Science and Technology
SN - 0013-936X
IS - 17
ER -