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    Rights statement: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Environmental Science and Technology, copyright ©2015 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/10.1021/acs.est.5b02412

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From bioavailability science to regulation of organic chemicals

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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From bioavailability science to regulation of organic chemicals. / Ortega-Calvo, Jose-J.; Harmsen, Joop; Parsons, John R. et al.
In: Environmental Science and Technology, Vol. 49, No. 17, 01.09.2015, p. 10255-10264.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Ortega-Calvo, J-J, Harmsen, J, Parsons, JR, Semple, KT, Aitken, MD, Ajao, C, Eadsforth, C, Galay-Burgos, M, Naidu, R, Oliver, R, Peijnenburg, WJGM, Roembke, J, Streck, G & Versonnen, B 2015, 'From bioavailability science to regulation of organic chemicals', Environmental Science and Technology, vol. 49, no. 17, pp. 10255-10264. https://doi.org/10.1021/acs.est.5b02412

APA

Ortega-Calvo, J-J., Harmsen, J., Parsons, J. R., Semple, K. T., Aitken, M. D., Ajao, C., Eadsforth, C., Galay-Burgos, M., Naidu, R., Oliver, R., Peijnenburg, W. J. G. M., Roembke, J., Streck, G., & Versonnen, B. (2015). From bioavailability science to regulation of organic chemicals. Environmental Science and Technology, 49(17), 10255-10264. https://doi.org/10.1021/acs.est.5b02412

Vancouver

Ortega-Calvo J-J, Harmsen J, Parsons JR, Semple KT, Aitken MD, Ajao C et al. From bioavailability science to regulation of organic chemicals. Environmental Science and Technology. 2015 Sept 1;49(17):10255-10264. Epub 2015 Jul 31. doi: 10.1021/acs.est.5b02412

Author

Ortega-Calvo, Jose-J. ; Harmsen, Joop ; Parsons, John R. et al. / From bioavailability science to regulation of organic chemicals. In: Environmental Science and Technology. 2015 ; Vol. 49, No. 17. pp. 10255-10264.

Bibtex

@article{199678f372ad4b98b22f3424f8566c4d,
title = "From bioavailability science to regulation of organic chemicals",
abstract = "The bioavailability of organic chemicals in soil and sediment is an important area of scientific investigation for environmental scientists, although this area of study remains only partially recognized by regulators and industries working in the environmental sector. Regulators have recently started to consider bioavailability within retrospective risk assessment frameworks for organic chemicals; by doing so, realistic decision-making with regard to polluted environments can be achieved, rather than relying on the traditional approach of using total-extractable concentrations. However, implementation remains difficult because scientific developments on bioavailability are not always translated into ready-to-use approaches for regulators. Similarly, bioavailability remains largely unexplored within prospective regulatory frameworks that address the approval and regulation of organic chemicals. This article discusses bioavailability concepts and methods, as well as possible pathways for the implementation of bioavailability into risk assessment and regulation; in addition, this article offers a simple, pragmatic and justifiable approach for use within retrospective and prospective risk assessment.",
keywords = "POLYCYCLIC AROMATIC-HYDROCARBONS, DESORPTION-KINETICS, CONTAMINATED SEDIMENTS, MICROBIAL AVAILABILITY, PAH BIOAVAILABILITY, IN-SITU, SOIL, EXTRACTION, BIODEGRADATION, FRAMEWORK",
author = "Jose-J. Ortega-Calvo and Joop Harmsen and Parsons, {John R.} and Semple, {Kirk T.} and Aitken, {Michael D.} and Charmaine Ajao and Charles Eadsforth and Malyka Galay-Burgos and Ravi Naidu and Robin Oliver and Peijnenburg, {Willie J. G. M.} and Joerg Roembke and Georg Streck and Bram Versonnen",
note = "This document is the Accepted Manuscript version of a Published Work that appeared in final form in Environmental Science and Technology, copyright {\textcopyright}2015 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/10.1021/acs.est.5b02412 ",
year = "2015",
month = sep,
day = "1",
doi = "10.1021/acs.est.5b02412",
language = "English",
volume = "49",
pages = "10255--10264",
journal = "Environmental Science and Technology",
issn = "0013-936X",
publisher = "American Chemical Society",
number = "17",

}

RIS

TY - JOUR

T1 - From bioavailability science to regulation of organic chemicals

AU - Ortega-Calvo, Jose-J.

AU - Harmsen, Joop

AU - Parsons, John R.

AU - Semple, Kirk T.

AU - Aitken, Michael D.

AU - Ajao, Charmaine

AU - Eadsforth, Charles

AU - Galay-Burgos, Malyka

AU - Naidu, Ravi

AU - Oliver, Robin

AU - Peijnenburg, Willie J. G. M.

AU - Roembke, Joerg

AU - Streck, Georg

AU - Versonnen, Bram

N1 - This document is the Accepted Manuscript version of a Published Work that appeared in final form in Environmental Science and Technology, copyright ©2015 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/10.1021/acs.est.5b02412

PY - 2015/9/1

Y1 - 2015/9/1

N2 - The bioavailability of organic chemicals in soil and sediment is an important area of scientific investigation for environmental scientists, although this area of study remains only partially recognized by regulators and industries working in the environmental sector. Regulators have recently started to consider bioavailability within retrospective risk assessment frameworks for organic chemicals; by doing so, realistic decision-making with regard to polluted environments can be achieved, rather than relying on the traditional approach of using total-extractable concentrations. However, implementation remains difficult because scientific developments on bioavailability are not always translated into ready-to-use approaches for regulators. Similarly, bioavailability remains largely unexplored within prospective regulatory frameworks that address the approval and regulation of organic chemicals. This article discusses bioavailability concepts and methods, as well as possible pathways for the implementation of bioavailability into risk assessment and regulation; in addition, this article offers a simple, pragmatic and justifiable approach for use within retrospective and prospective risk assessment.

AB - The bioavailability of organic chemicals in soil and sediment is an important area of scientific investigation for environmental scientists, although this area of study remains only partially recognized by regulators and industries working in the environmental sector. Regulators have recently started to consider bioavailability within retrospective risk assessment frameworks for organic chemicals; by doing so, realistic decision-making with regard to polluted environments can be achieved, rather than relying on the traditional approach of using total-extractable concentrations. However, implementation remains difficult because scientific developments on bioavailability are not always translated into ready-to-use approaches for regulators. Similarly, bioavailability remains largely unexplored within prospective regulatory frameworks that address the approval and regulation of organic chemicals. This article discusses bioavailability concepts and methods, as well as possible pathways for the implementation of bioavailability into risk assessment and regulation; in addition, this article offers a simple, pragmatic and justifiable approach for use within retrospective and prospective risk assessment.

KW - POLYCYCLIC AROMATIC-HYDROCARBONS

KW - DESORPTION-KINETICS

KW - CONTAMINATED SEDIMENTS

KW - MICROBIAL AVAILABILITY

KW - PAH BIOAVAILABILITY

KW - IN-SITU

KW - SOIL

KW - EXTRACTION

KW - BIODEGRADATION

KW - FRAMEWORK

U2 - 10.1021/acs.est.5b02412

DO - 10.1021/acs.est.5b02412

M3 - Journal article

VL - 49

SP - 10255

EP - 10264

JO - Environmental Science and Technology

JF - Environmental Science and Technology

SN - 0013-936X

IS - 17

ER -