Rights statement: © 2018 Springer Nature Limited. All rights reserved. The Author's Accepted Manuscript (the accepted version of the manuscript as submitted by the author) may only be posted 6 months after the paper is published, consistent with our self-archiving embargo. Please note that the Author’s Accepted Manuscript may not be released under a Creative Commons license. For Nature Research Terms of Reuse of archived manuscripts please see: http://www.nature.com/authors/policies/license.html#terms
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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
AU - Evangelou, Evangelos
AU - Warren, Helen R
AU - Mosen-Ansorena, David
AU - Mifsud, Borbala
AU - Pazoki, Raha
AU - Gao, He
AU - Ntritsos, Georgios
AU - Dimou, Niki
AU - Cabrera, Claudia P
AU - Karaman, Ibrahim
AU - Ng, Fu Liang
AU - Evangelou, Marina
AU - Witkowska, Katarzyna
AU - Tzanis, Evan
AU - Hellwege, Jacklyn N
AU - Giri, Ayush
AU - Velez Edwards, Digna R
AU - Sun, Yan V
AU - Cho, Kelly
AU - Gaziano, J Michael
AU - Wilson, Peter W F
AU - Tsao, Philip S
AU - Kovesdy, Csaba P
AU - Esko, Tonu
AU - Mägi, Reedik
AU - Milani, Lili
AU - Almgren, Peter
AU - Boutin, Thibaud
AU - Debette, Stéphanie
AU - Ding, Jun
AU - Giulianini, Franco
AU - Holliday, Elizabeth G
AU - Jackson, Anne U
AU - Li-Gao, Ruifang
AU - Lin, Wei-Yu
AU - Luan, Jian'an
AU - Mangino, Massimo
AU - Oldmeadow, Christopher
AU - Prins, Bram Peter
AU - Qian, Yong
AU - Sargurupremraj, Muralidharan
AU - Shah, Nabi
AU - Surendran, Praveen
AU - Thériault, Sébastien
AU - Verweij, Niek
AU - Willems, Sara M
AU - Zhao, Jing-Hua
AU - Amouyel, Philippe
AU - Connell, John
AU - Knight, Joanne
AU - Million Veteran Program
N1 - © 2018 Springer Nature Limited. All rights reserved. The Author's Accepted Manuscript (the accepted version of the manuscript as submitted by the author) may only be posted 6 months after the paper is published, consistent with our self-archiving embargo. Please note that the Author’s Accepted Manuscript may not be released under a Creative Commons license. For Nature Research Terms of Reuse of archived manuscripts please see: http://www.nature.com/authors/policies/license.html#terms
PY - 2018/9/17
Y1 - 2018/9/17
N2 - High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
AB - High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
KW - Journal Article
U2 - 10.1038/s41588-018-0205-x
DO - 10.1038/s41588-018-0205-x
M3 - Journal article
C2 - 30224653
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
ER -