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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. / Evangelou, Evangelos; Warren, Helen R; Mosen-Ansorena, David; Mifsud, Borbala; Pazoki, Raha; Gao, He; Ntritsos, Georgios; Dimou, Niki; Cabrera, Claudia P; Karaman, Ibrahim; Ng, Fu Liang; Evangelou, Marina; Witkowska, Katarzyna; Tzanis, Evan; Hellwege, Jacklyn N; Giri, Ayush; Velez Edwards, Digna R; Sun, Yan V; Cho, Kelly; Gaziano, J Michael; Wilson, Peter W F; Tsao, Philip S; Kovesdy, Csaba P; Esko, Tonu; Mägi, Reedik; Milani, Lili; Almgren, Peter; Boutin, Thibaud; Debette, Stéphanie; Ding, Jun; Giulianini, Franco; Holliday, Elizabeth G; Jackson, Anne U; Li-Gao, Ruifang; Lin, Wei-Yu; Luan, Jian'an; Mangino, Massimo; Oldmeadow, Christopher; Prins, Bram Peter; Qian, Yong; Sargurupremraj, Muralidharan; Shah, Nabi; Surendran, Praveen; Thériault, Sébastien; Verweij, Niek; Willems, Sara M; Zhao, Jing-Hua; Amouyel, Philippe; Connell, John; Knight, Joanne; Million Veteran Program.

In: Nature Genetics, 17.09.2018.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Evangelou, E, Warren, HR, Mosen-Ansorena, D, Mifsud, B, Pazoki, R, Gao, H, Ntritsos, G, Dimou, N, Cabrera, CP, Karaman, I, Ng, FL, Evangelou, M, Witkowska, K, Tzanis, E, Hellwege, JN, Giri, A, Velez Edwards, DR, Sun, YV, Cho, K, Gaziano, JM, Wilson, PWF, Tsao, PS, Kovesdy, CP, Esko, T, Mägi, R, Milani, L, Almgren, P, Boutin, T, Debette, S, Ding, J, Giulianini, F, Holliday, EG, Jackson, AU, Li-Gao, R, Lin, W-Y, Luan, J, Mangino, M, Oldmeadow, C, Prins, BP, Qian, Y, Sargurupremraj, M, Shah, N, Surendran, P, Thériault, S, Verweij, N, Willems, SM, Zhao, J-H, Amouyel, P, Connell, J, Knight, J & Million Veteran Program 2018, 'Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits', Nature Genetics. https://doi.org/10.1038/s41588-018-0205-x

APA

Evangelou, E., Warren, H. R., Mosen-Ansorena, D., Mifsud, B., Pazoki, R., Gao, H., Ntritsos, G., Dimou, N., Cabrera, C. P., Karaman, I., Ng, F. L., Evangelou, M., Witkowska, K., Tzanis, E., Hellwege, J. N., Giri, A., Velez Edwards, D. R., Sun, Y. V., Cho, K., ... Million Veteran Program (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics. https://doi.org/10.1038/s41588-018-0205-x

Vancouver

Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H et al. Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics. 2018 Sep 17. https://doi.org/10.1038/s41588-018-0205-x

Author

Evangelou, Evangelos ; Warren, Helen R ; Mosen-Ansorena, David ; Mifsud, Borbala ; Pazoki, Raha ; Gao, He ; Ntritsos, Georgios ; Dimou, Niki ; Cabrera, Claudia P ; Karaman, Ibrahim ; Ng, Fu Liang ; Evangelou, Marina ; Witkowska, Katarzyna ; Tzanis, Evan ; Hellwege, Jacklyn N ; Giri, Ayush ; Velez Edwards, Digna R ; Sun, Yan V ; Cho, Kelly ; Gaziano, J Michael ; Wilson, Peter W F ; Tsao, Philip S ; Kovesdy, Csaba P ; Esko, Tonu ; Mägi, Reedik ; Milani, Lili ; Almgren, Peter ; Boutin, Thibaud ; Debette, Stéphanie ; Ding, Jun ; Giulianini, Franco ; Holliday, Elizabeth G ; Jackson, Anne U ; Li-Gao, Ruifang ; Lin, Wei-Yu ; Luan, Jian'an ; Mangino, Massimo ; Oldmeadow, Christopher ; Prins, Bram Peter ; Qian, Yong ; Sargurupremraj, Muralidharan ; Shah, Nabi ; Surendran, Praveen ; Thériault, Sébastien ; Verweij, Niek ; Willems, Sara M ; Zhao, Jing-Hua ; Amouyel, Philippe ; Connell, John ; Knight, Joanne ; Million Veteran Program. / Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. In: Nature Genetics. 2018.

Bibtex

@article{80fd689d872b4770a76666931a2febe8,
title = "Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits",
abstract = "High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.",
keywords = "Journal Article",
author = "Evangelos Evangelou and Warren, {Helen R} and David Mosen-Ansorena and Borbala Mifsud and Raha Pazoki and He Gao and Georgios Ntritsos and Niki Dimou and Cabrera, {Claudia P} and Ibrahim Karaman and Ng, {Fu Liang} and Marina Evangelou and Katarzyna Witkowska and Evan Tzanis and Hellwege, {Jacklyn N} and Ayush Giri and {Velez Edwards}, {Digna R} and Sun, {Yan V} and Kelly Cho and Gaziano, {J Michael} and Wilson, {Peter W F} and Tsao, {Philip S} and Kovesdy, {Csaba P} and Tonu Esko and Reedik M{\"a}gi and Lili Milani and Peter Almgren and Thibaud Boutin and St{\'e}phanie Debette and Jun Ding and Franco Giulianini and Holliday, {Elizabeth G} and Jackson, {Anne U} and Ruifang Li-Gao and Wei-Yu Lin and Jian'an Luan and Massimo Mangino and Christopher Oldmeadow and Prins, {Bram Peter} and Yong Qian and Muralidharan Sargurupremraj and Nabi Shah and Praveen Surendran and S{\'e}bastien Th{\'e}riault and Niek Verweij and Willems, {Sara M} and Jing-Hua Zhao and Philippe Amouyel and John Connell and Joanne Knight and {Million Veteran Program}",
note = "{\textcopyright} 2018 Springer Nature Limited. All rights reserved. The Author's Accepted Manuscript (the accepted version of the manuscript as submitted by the author) may only be posted 6 months after the paper is published, consistent with our self-archiving embargo. Please note that the Author{\textquoteright}s Accepted Manuscript may not be released under a Creative Commons license. For Nature Research Terms of Reuse of archived manuscripts please see: http://www.nature.com/authors/policies/license.html#terms ",
year = "2018",
month = sep,
day = "17",
doi = "10.1038/s41588-018-0205-x",
language = "English",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

AU - Evangelou, Evangelos

AU - Warren, Helen R

AU - Mosen-Ansorena, David

AU - Mifsud, Borbala

AU - Pazoki, Raha

AU - Gao, He

AU - Ntritsos, Georgios

AU - Dimou, Niki

AU - Cabrera, Claudia P

AU - Karaman, Ibrahim

AU - Ng, Fu Liang

AU - Evangelou, Marina

AU - Witkowska, Katarzyna

AU - Tzanis, Evan

AU - Hellwege, Jacklyn N

AU - Giri, Ayush

AU - Velez Edwards, Digna R

AU - Sun, Yan V

AU - Cho, Kelly

AU - Gaziano, J Michael

AU - Wilson, Peter W F

AU - Tsao, Philip S

AU - Kovesdy, Csaba P

AU - Esko, Tonu

AU - Mägi, Reedik

AU - Milani, Lili

AU - Almgren, Peter

AU - Boutin, Thibaud

AU - Debette, Stéphanie

AU - Ding, Jun

AU - Giulianini, Franco

AU - Holliday, Elizabeth G

AU - Jackson, Anne U

AU - Li-Gao, Ruifang

AU - Lin, Wei-Yu

AU - Luan, Jian'an

AU - Mangino, Massimo

AU - Oldmeadow, Christopher

AU - Prins, Bram Peter

AU - Qian, Yong

AU - Sargurupremraj, Muralidharan

AU - Shah, Nabi

AU - Surendran, Praveen

AU - Thériault, Sébastien

AU - Verweij, Niek

AU - Willems, Sara M

AU - Zhao, Jing-Hua

AU - Amouyel, Philippe

AU - Connell, John

AU - Knight, Joanne

AU - Million Veteran Program

N1 - © 2018 Springer Nature Limited. All rights reserved. The Author's Accepted Manuscript (the accepted version of the manuscript as submitted by the author) may only be posted 6 months after the paper is published, consistent with our self-archiving embargo. Please note that the Author’s Accepted Manuscript may not be released under a Creative Commons license. For Nature Research Terms of Reuse of archived manuscripts please see: http://www.nature.com/authors/policies/license.html#terms

PY - 2018/9/17

Y1 - 2018/9/17

N2 - High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

AB - High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

KW - Journal Article

U2 - 10.1038/s41588-018-0205-x

DO - 10.1038/s41588-018-0205-x

M3 - Journal article

C2 - 30224653

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

ER -