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Genetic variation is associated with PTSD risk and aversive memory: Evidence from two trauma-Exposed African samples and one healthy European sample

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Genetic variation is associated with PTSD risk and aversive memory: Evidence from two trauma-Exposed African samples and one healthy European sample. / Wilker, Sarah; Schneider, Anna; Conrad, Daniela et al.
In: Translational Psychiatry, Vol. 8, No. 1, 251, 01.12.2018.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Wilker, S, Schneider, A, Conrad, D, Pfeiffer, A, Boeck, C, Lingenfelder, B, Freytag, V, Vukojevic, V, Vogler, C, Milnik, A, Papassotiropoulos, A, J.-F. de Quervain, D, Elbert, T, Kolassa, S & Kolassa, IT 2018, 'Genetic variation is associated with PTSD risk and aversive memory: Evidence from two trauma-Exposed African samples and one healthy European sample', Translational Psychiatry, vol. 8, no. 1, 251. https://doi.org/10.1038/s41398-018-0297-1

APA

Wilker, S., Schneider, A., Conrad, D., Pfeiffer, A., Boeck, C., Lingenfelder, B., Freytag, V., Vukojevic, V., Vogler, C., Milnik, A., Papassotiropoulos, A., J.-F. de Quervain, D., Elbert, T., Kolassa, S., & Kolassa, I. T. (2018). Genetic variation is associated with PTSD risk and aversive memory: Evidence from two trauma-Exposed African samples and one healthy European sample. Translational Psychiatry, 8(1), Article 251. https://doi.org/10.1038/s41398-018-0297-1

Vancouver

Wilker S, Schneider A, Conrad D, Pfeiffer A, Boeck C, Lingenfelder B et al. Genetic variation is associated with PTSD risk and aversive memory: Evidence from two trauma-Exposed African samples and one healthy European sample. Translational Psychiatry. 2018 Dec 1;8(1):251. doi: 10.1038/s41398-018-0297-1

Author

Wilker, Sarah ; Schneider, Anna ; Conrad, Daniela et al. / Genetic variation is associated with PTSD risk and aversive memory : Evidence from two trauma-Exposed African samples and one healthy European sample. In: Translational Psychiatry. 2018 ; Vol. 8, No. 1.

Bibtex

@article{d4fd9d840cf24af1b1c03a868cb4ea63,
title = "Genetic variation is associated with PTSD risk and aversive memory: Evidence from two trauma-Exposed African samples and one healthy European sample",
abstract = "The probability to develop posttraumatic stress disorder (PTSD), characterized by vivid, intrusive emotional memories of the encountered traumatic events, depends - among other factors - on the number of previous traumatic experiences (traumatic load) and individual genetic vulnerability. So far, our knowledge regarding the biological underpinnings of PTSD is relatively sparse. Genome-wide association studies (GWAS) followed by independent replication might help to discover novel, so far unknown biological mechanisms associated with the development of traumatic memories. Here, a GWAS was conducted in N = 924 Northern Ugandan rebel war survivors and identified seven suggestively significant single nucleotide polymorphisms (SNPs; p ≤ 1 × 10−5) for lifetime PTSD risk. Of these seven SNPs, the association of rs3852144 on chromosome 5 was replicated in an independent sample of Rwandan genocide survivors (N = 370, p <.01). While PTSD risk increased with accumulating traumatic experiences, the vulnerability was reduced in carriers of the minor G-allele in an additive manner. Correspondingly, memory for aversive pictures decreased with higher number of the minor G-allele in a sample of N = 2698 healthy Swiss individuals. Finally, investigations on N = 90 PTSD patients treated with Narrative Exposure Therapy indicated an additive effect of genotype on PTSD symptom change from pre-treatment to four months after treatment, but not between pre-treatment and the 10-months follow-up. In conclusion, emotional memory formation seems to decline with increasing number of rs3852144 G-alleles, rendering individuals more resilient to PTSD development. However, the impact on therapy outcome remains preliminary and further research is needed to determine how this intronic marker may affect memory processes in detail.",
author = "Sarah Wilker and Anna Schneider and Daniela Conrad and Anett Pfeiffer and Christina Boeck and Birke Lingenfelder and Virginie Freytag and Vanja Vukojevic and Christian Vogler and Annette Milnik and Andreas Papassotiropoulos and {J.-F. de Quervain}, Dominique and Thomas Elbert and Stephan Kolassa and Kolassa, {Iris Tatjana}",
note = "Publisher Copyright: {\textcopyright} 2018, The Author(s).",
year = "2018",
month = dec,
day = "1",
doi = "10.1038/s41398-018-0297-1",
language = "English",
volume = "8",
journal = "Translational Psychiatry",
issn = "2158-3188",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Genetic variation is associated with PTSD risk and aversive memory

T2 - Evidence from two trauma-Exposed African samples and one healthy European sample

AU - Wilker, Sarah

AU - Schneider, Anna

AU - Conrad, Daniela

AU - Pfeiffer, Anett

AU - Boeck, Christina

AU - Lingenfelder, Birke

AU - Freytag, Virginie

AU - Vukojevic, Vanja

AU - Vogler, Christian

AU - Milnik, Annette

AU - Papassotiropoulos, Andreas

AU - J.-F. de Quervain, Dominique

AU - Elbert, Thomas

AU - Kolassa, Stephan

AU - Kolassa, Iris Tatjana

N1 - Publisher Copyright: © 2018, The Author(s).

PY - 2018/12/1

Y1 - 2018/12/1

N2 - The probability to develop posttraumatic stress disorder (PTSD), characterized by vivid, intrusive emotional memories of the encountered traumatic events, depends - among other factors - on the number of previous traumatic experiences (traumatic load) and individual genetic vulnerability. So far, our knowledge regarding the biological underpinnings of PTSD is relatively sparse. Genome-wide association studies (GWAS) followed by independent replication might help to discover novel, so far unknown biological mechanisms associated with the development of traumatic memories. Here, a GWAS was conducted in N = 924 Northern Ugandan rebel war survivors and identified seven suggestively significant single nucleotide polymorphisms (SNPs; p ≤ 1 × 10−5) for lifetime PTSD risk. Of these seven SNPs, the association of rs3852144 on chromosome 5 was replicated in an independent sample of Rwandan genocide survivors (N = 370, p <.01). While PTSD risk increased with accumulating traumatic experiences, the vulnerability was reduced in carriers of the minor G-allele in an additive manner. Correspondingly, memory for aversive pictures decreased with higher number of the minor G-allele in a sample of N = 2698 healthy Swiss individuals. Finally, investigations on N = 90 PTSD patients treated with Narrative Exposure Therapy indicated an additive effect of genotype on PTSD symptom change from pre-treatment to four months after treatment, but not between pre-treatment and the 10-months follow-up. In conclusion, emotional memory formation seems to decline with increasing number of rs3852144 G-alleles, rendering individuals more resilient to PTSD development. However, the impact on therapy outcome remains preliminary and further research is needed to determine how this intronic marker may affect memory processes in detail.

AB - The probability to develop posttraumatic stress disorder (PTSD), characterized by vivid, intrusive emotional memories of the encountered traumatic events, depends - among other factors - on the number of previous traumatic experiences (traumatic load) and individual genetic vulnerability. So far, our knowledge regarding the biological underpinnings of PTSD is relatively sparse. Genome-wide association studies (GWAS) followed by independent replication might help to discover novel, so far unknown biological mechanisms associated with the development of traumatic memories. Here, a GWAS was conducted in N = 924 Northern Ugandan rebel war survivors and identified seven suggestively significant single nucleotide polymorphisms (SNPs; p ≤ 1 × 10−5) for lifetime PTSD risk. Of these seven SNPs, the association of rs3852144 on chromosome 5 was replicated in an independent sample of Rwandan genocide survivors (N = 370, p <.01). While PTSD risk increased with accumulating traumatic experiences, the vulnerability was reduced in carriers of the minor G-allele in an additive manner. Correspondingly, memory for aversive pictures decreased with higher number of the minor G-allele in a sample of N = 2698 healthy Swiss individuals. Finally, investigations on N = 90 PTSD patients treated with Narrative Exposure Therapy indicated an additive effect of genotype on PTSD symptom change from pre-treatment to four months after treatment, but not between pre-treatment and the 10-months follow-up. In conclusion, emotional memory formation seems to decline with increasing number of rs3852144 G-alleles, rendering individuals more resilient to PTSD development. However, the impact on therapy outcome remains preliminary and further research is needed to determine how this intronic marker may affect memory processes in detail.

UR - http://www.scopus.com/inward/record.url?scp=85057085335&partnerID=8YFLogxK

U2 - 10.1038/s41398-018-0297-1

DO - 10.1038/s41398-018-0297-1

M3 - Journal article

C2 - 30467376

AN - SCOPUS:85057085335

VL - 8

JO - Translational Psychiatry

JF - Translational Psychiatry

SN - 2158-3188

IS - 1

M1 - 251

ER -