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GRADE Concept Paper 9: Rationale and process for creating a GRADE Ontology

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GRADE Concept Paper 9: Rationale and process for creating a GRADE Ontology. / Whaley, Paul; Alper, Brian S; Dehnbostel, Joanne et al.
In: Journal of clinical epidemiology, 31.07.2025.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Whaley, P, Alper, BS, Dehnbostel, J, Alva-Diaz, C, Antoniou, SA, Bognanni, A, Bracchiglione, J, Dalsbø, TK, Grant, S, Hunter, J, Iorio, A, Lagisz, M, Lehmann, H, Li, S, Meerpohl, JJ, Mokrane, S, Monaco, CF, Neumann, I, Pottie, K, Sayfi, S, Sekercioglu, N, Singh, JA, Sousa-Pinto, B, Tufte, J, Vasanthan, LT, Wang, L, Xia, J, Yao, X & Schünemann, H 2025, 'GRADE Concept Paper 9: Rationale and process for creating a GRADE Ontology', Journal of clinical epidemiology. https://doi.org/10.1016/j.jclinepi.2025.111921

APA

Whaley, P., Alper, B. S., Dehnbostel, J., Alva-Diaz, C., Antoniou, S. A., Bognanni, A., Bracchiglione, J., Dalsbø, T. K., Grant, S., Hunter, J., Iorio, A., Lagisz, M., Lehmann, H., Li, S., Meerpohl, J. J., Mokrane, S., Monaco, C. F., Neumann, I., Pottie, K., ... Schünemann, H. (in press). GRADE Concept Paper 9: Rationale and process for creating a GRADE Ontology. Journal of clinical epidemiology, Article 111921. https://doi.org/10.1016/j.jclinepi.2025.111921

Vancouver

Whaley P, Alper BS, Dehnbostel J, Alva-Diaz C, Antoniou SA, Bognanni A et al. GRADE Concept Paper 9: Rationale and process for creating a GRADE Ontology. Journal of clinical epidemiology. 2025 Jul 31;111921. doi: 10.1016/j.jclinepi.2025.111921

Author

Whaley, Paul ; Alper, Brian S ; Dehnbostel, Joanne et al. / GRADE Concept Paper 9 : Rationale and process for creating a GRADE Ontology. In: Journal of clinical epidemiology. 2025.

Bibtex

@article{9cee7778b2754569b6e07c9408cdabad,
title = "GRADE Concept Paper 9: Rationale and process for creating a GRADE Ontology",
abstract = "As the rate of research production accelerates, the ability to efficiently and unambiguously communicate judgements relating to the synthesis, evaluation, and use of scientific information becomes paramount. Scientific information can be viewed as a {"}layered infrastructure{"} of data, evidence, knowledge, and use. The GRADE approach serves as a de facto data standard in this infrastructure, reducing ambiguity in claims to knowledge (in the form of judgements of certainty in the evidence when answering research questions) and level of commitment to possible solutions to problems (in the form of strength of recommendations for interventions). However, the absence of a formalised terminology standard within GRADE limits the efficiency, rigour, consistency, and interoperability with which it is used. This GRADE concept paper outlines the potential benefits of a GRADE Ontology for the creators, educators, and users of systematic reviews, health guidelines, and health technology assessments, and the development of tools that help with conducting, finding, and summarising the same. It also presents the processes for the development and maintenance of the GRADE Ontology. [Abstract copyright: Copyright {\textcopyright} 2025. Published by Elsevier Inc.]",
keywords = "evidence-to-decisions, certainty of evidence, data standards, GRADE approach, ontology",
author = "Paul Whaley and Alper, {Brian S} and Joanne Dehnbostel and Carlos Alva-Diaz and Antoniou, {Stavros A} and Antonio Bognanni and Javier Bracchiglione and Dalsb{\o}, {Therese Kristine} and Sean Grant and Jennifer Hunter and Alfonso Iorio and Malgorzata Lagisz and Harold Lehmann and Sheyu Li and Meerpohl, {Joerg J} and Saphia Mokrane and Monaco, {Cau{\^e} F} and Ignacio Neumann and Kevin Pottie and Shahab Sayfi and Nigar Sekercioglu and Singh, {Jasvinder A} and Bernardo Sousa-Pinto and Janice Tufte and Vasanthan, {Lenny Thinagaran} and Li Wang and Jun Xia and Xiaomei Yao and Holger Sch{\"u}nemann",
year = "2025",
month = jul,
day = "31",
doi = "10.1016/j.jclinepi.2025.111921",
language = "English",
journal = "Journal of clinical epidemiology",
issn = "0895-4356",
publisher = "Elsevier USA",

}

RIS

TY - JOUR

T1 - GRADE Concept Paper 9

T2 - Rationale and process for creating a GRADE Ontology

AU - Whaley, Paul

AU - Alper, Brian S

AU - Dehnbostel, Joanne

AU - Alva-Diaz, Carlos

AU - Antoniou, Stavros A

AU - Bognanni, Antonio

AU - Bracchiglione, Javier

AU - Dalsbø, Therese Kristine

AU - Grant, Sean

AU - Hunter, Jennifer

AU - Iorio, Alfonso

AU - Lagisz, Malgorzata

AU - Lehmann, Harold

AU - Li, Sheyu

AU - Meerpohl, Joerg J

AU - Mokrane, Saphia

AU - Monaco, Cauê F

AU - Neumann, Ignacio

AU - Pottie, Kevin

AU - Sayfi, Shahab

AU - Sekercioglu, Nigar

AU - Singh, Jasvinder A

AU - Sousa-Pinto, Bernardo

AU - Tufte, Janice

AU - Vasanthan, Lenny Thinagaran

AU - Wang, Li

AU - Xia, Jun

AU - Yao, Xiaomei

AU - Schünemann, Holger

PY - 2025/7/31

Y1 - 2025/7/31

N2 - As the rate of research production accelerates, the ability to efficiently and unambiguously communicate judgements relating to the synthesis, evaluation, and use of scientific information becomes paramount. Scientific information can be viewed as a "layered infrastructure" of data, evidence, knowledge, and use. The GRADE approach serves as a de facto data standard in this infrastructure, reducing ambiguity in claims to knowledge (in the form of judgements of certainty in the evidence when answering research questions) and level of commitment to possible solutions to problems (in the form of strength of recommendations for interventions). However, the absence of a formalised terminology standard within GRADE limits the efficiency, rigour, consistency, and interoperability with which it is used. This GRADE concept paper outlines the potential benefits of a GRADE Ontology for the creators, educators, and users of systematic reviews, health guidelines, and health technology assessments, and the development of tools that help with conducting, finding, and summarising the same. It also presents the processes for the development and maintenance of the GRADE Ontology. [Abstract copyright: Copyright © 2025. Published by Elsevier Inc.]

AB - As the rate of research production accelerates, the ability to efficiently and unambiguously communicate judgements relating to the synthesis, evaluation, and use of scientific information becomes paramount. Scientific information can be viewed as a "layered infrastructure" of data, evidence, knowledge, and use. The GRADE approach serves as a de facto data standard in this infrastructure, reducing ambiguity in claims to knowledge (in the form of judgements of certainty in the evidence when answering research questions) and level of commitment to possible solutions to problems (in the form of strength of recommendations for interventions). However, the absence of a formalised terminology standard within GRADE limits the efficiency, rigour, consistency, and interoperability with which it is used. This GRADE concept paper outlines the potential benefits of a GRADE Ontology for the creators, educators, and users of systematic reviews, health guidelines, and health technology assessments, and the development of tools that help with conducting, finding, and summarising the same. It also presents the processes for the development and maintenance of the GRADE Ontology. [Abstract copyright: Copyright © 2025. Published by Elsevier Inc.]

KW - evidence-to-decisions

KW - certainty of evidence

KW - data standards

KW - GRADE approach

KW - ontology

U2 - 10.1016/j.jclinepi.2025.111921

DO - 10.1016/j.jclinepi.2025.111921

M3 - Journal article

C2 - 40769258

JO - Journal of clinical epidemiology

JF - Journal of clinical epidemiology

SN - 0895-4356

M1 - 111921

ER -