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Graphene sculpturene nanopores for DNA nucleobase sensing

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Graphene sculpturene nanopores for DNA nucleobase sensing. / Sadeghi, Hatef; Algaragholy, L.; Pope, T. et al.
In: Journal of Physical Chemistry B, Vol. 118, No. 24, 19.06.2014, p. 6908-6914.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Sadeghi, H, Algaragholy, L, Pope, T, Bailey, S, Visontai, D, Manrique, D, Ferrer, J, Garcia-Suarez, V, Sangtarash, S & Lambert, CJ 2014, 'Graphene sculpturene nanopores for DNA nucleobase sensing', Journal of Physical Chemistry B, vol. 118, no. 24, pp. 6908-6914. https://doi.org/10.1021/jp5034917

APA

Sadeghi, H., Algaragholy, L., Pope, T., Bailey, S., Visontai, D., Manrique, D., Ferrer, J., Garcia-Suarez, V., Sangtarash, S., & Lambert, C. J. (2014). Graphene sculpturene nanopores for DNA nucleobase sensing. Journal of Physical Chemistry B, 118(24), 6908-6914. https://doi.org/10.1021/jp5034917

Vancouver

Sadeghi H, Algaragholy L, Pope T, Bailey S, Visontai D, Manrique D et al. Graphene sculpturene nanopores for DNA nucleobase sensing. Journal of Physical Chemistry B. 2014 Jun 19;118(24):6908-6914. doi: 10.1021/jp5034917

Author

Sadeghi, Hatef ; Algaragholy, L. ; Pope, T. et al. / Graphene sculpturene nanopores for DNA nucleobase sensing. In: Journal of Physical Chemistry B. 2014 ; Vol. 118, No. 24. pp. 6908-6914.

Bibtex

@article{5047450ef93945e2999da27b083c599a,
title = "Graphene sculpturene nanopores for DNA nucleobase sensing",
abstract = "To demonstrate the potential of nanopores in bilayer graphene for DNA sequencing, we computed the current-voltage characteristics of a bilayer graphene junction containing a nanopore and found that they change significantly when nucleobases are transported through the pore. To demonstrate the sensitivity and selectivity of example devices, we computed the probability distribution P-X(beta) of the quantity beta representing the change in the logarithmic current through the pore due to the presence of a nucleobase X (X = adenine, thymine, guanine, or cytosine). We quantified the selectivity of the bilayer-graphene nanopores by showing that P-X(beta) exhibits distinct peaks for each base X. To demonstrate that such discriminating sensing is a general feature of bilayer nanopores, the well-separated positions of these peaks were shown to be present for different pores, with alternative examples of electrical contacts.",
keywords = "SOLID-STATE NANOPORES, ELECTROCHEMICAL SENSOR, SEQUENCING TECHNOLOGIES, SENSITIVE DETECTION, CARBON NANOTUBES, BIOSENSORS, SINGLE, TRANSLOCATION, GENERATIONS, CHALLENGES",
author = "Hatef Sadeghi and L. Algaragholy and T. Pope and S. Bailey and D. Visontai and D. Manrique and J. Ferrer and V. Garcia-Suarez and Sara Sangtarash and Lambert, {Colin J.}",
year = "2014",
month = jun,
day = "19",
doi = "10.1021/jp5034917",
language = "English",
volume = "118",
pages = "6908--6914",
journal = "Journal of Physical Chemistry B",
issn = "1520-6106",
publisher = "AMER CHEMICAL SOC",
number = "24",

}

RIS

TY - JOUR

T1 - Graphene sculpturene nanopores for DNA nucleobase sensing

AU - Sadeghi, Hatef

AU - Algaragholy, L.

AU - Pope, T.

AU - Bailey, S.

AU - Visontai, D.

AU - Manrique, D.

AU - Ferrer, J.

AU - Garcia-Suarez, V.

AU - Sangtarash, Sara

AU - Lambert, Colin J.

PY - 2014/6/19

Y1 - 2014/6/19

N2 - To demonstrate the potential of nanopores in bilayer graphene for DNA sequencing, we computed the current-voltage characteristics of a bilayer graphene junction containing a nanopore and found that they change significantly when nucleobases are transported through the pore. To demonstrate the sensitivity and selectivity of example devices, we computed the probability distribution P-X(beta) of the quantity beta representing the change in the logarithmic current through the pore due to the presence of a nucleobase X (X = adenine, thymine, guanine, or cytosine). We quantified the selectivity of the bilayer-graphene nanopores by showing that P-X(beta) exhibits distinct peaks for each base X. To demonstrate that such discriminating sensing is a general feature of bilayer nanopores, the well-separated positions of these peaks were shown to be present for different pores, with alternative examples of electrical contacts.

AB - To demonstrate the potential of nanopores in bilayer graphene for DNA sequencing, we computed the current-voltage characteristics of a bilayer graphene junction containing a nanopore and found that they change significantly when nucleobases are transported through the pore. To demonstrate the sensitivity and selectivity of example devices, we computed the probability distribution P-X(beta) of the quantity beta representing the change in the logarithmic current through the pore due to the presence of a nucleobase X (X = adenine, thymine, guanine, or cytosine). We quantified the selectivity of the bilayer-graphene nanopores by showing that P-X(beta) exhibits distinct peaks for each base X. To demonstrate that such discriminating sensing is a general feature of bilayer nanopores, the well-separated positions of these peaks were shown to be present for different pores, with alternative examples of electrical contacts.

KW - SOLID-STATE NANOPORES

KW - ELECTROCHEMICAL SENSOR

KW - SEQUENCING TECHNOLOGIES

KW - SENSITIVE DETECTION

KW - CARBON NANOTUBES

KW - BIOSENSORS

KW - SINGLE

KW - TRANSLOCATION

KW - GENERATIONS

KW - CHALLENGES

U2 - 10.1021/jp5034917

DO - 10.1021/jp5034917

M3 - Journal article

VL - 118

SP - 6908

EP - 6914

JO - Journal of Physical Chemistry B

JF - Journal of Physical Chemistry B

SN - 1520-6106

IS - 24

ER -