Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Highly water-stable bimetallic organic framework MgCu-MOF74 for inhibiting bacterial infection and promoting bone regeneration
AU - Liu, Jiamin
AU - Tan, Yanni
AU - Shen, Erdong
AU - Liu, Bo
AU - Tian, Yingtao
AU - Liang, Luxin
AU - Yan, Xinxin
AU - Wu, Hong
PY - 2022/11/23
Y1 - 2022/11/23
N2 - As a typical metal-organic framework (MOF), Mg-MOF74 can release biocompatible Mg 2+when the framework is degraded, and it has the potential to be used as filler in the field of bone tissue engineering. However, Mg-MOF74 has poor stability in aqueous environment and limited antibacterial ability, which limit its further development and applications. In this work, MgCu-MOF74 particles with different Cu content were synthesized through a facile one-step hydrothermal method. The physicochemical properties and water stability of the synthesized powders were characterized. The osteogenic potential of the MgCu-MOF74 particles on human osteogenic sarcoma cells (SaOS-2) was evaluated. The hybrid MgCu-MOF74 exhibited favorable water stability. These results indicated that MgCu-MOF74 enhanced cellular viability, alkaline phosphatase levels, collagen (COL) synthesis and osteogenesis-related gene expression. Moreover, the samples doped with Cu 2+were more sensitive to the acidic microenvironment produced by bacteria, and exhibited stronger antibacterial ability than Mg-MOF74. In conclusion, MgCu-MOF-74 with good water stability, osteogenic ability and antibacterial ability, which could be attributed to the doping of Cu 2+. Hence, MgCu-MOF74 shows great potential as a novel medical bio-functional fillers for the treatment of bone defects.
AB - As a typical metal-organic framework (MOF), Mg-MOF74 can release biocompatible Mg 2+when the framework is degraded, and it has the potential to be used as filler in the field of bone tissue engineering. However, Mg-MOF74 has poor stability in aqueous environment and limited antibacterial ability, which limit its further development and applications. In this work, MgCu-MOF74 particles with different Cu content were synthesized through a facile one-step hydrothermal method. The physicochemical properties and water stability of the synthesized powders were characterized. The osteogenic potential of the MgCu-MOF74 particles on human osteogenic sarcoma cells (SaOS-2) was evaluated. The hybrid MgCu-MOF74 exhibited favorable water stability. These results indicated that MgCu-MOF74 enhanced cellular viability, alkaline phosphatase levels, collagen (COL) synthesis and osteogenesis-related gene expression. Moreover, the samples doped with Cu 2+were more sensitive to the acidic microenvironment produced by bacteria, and exhibited stronger antibacterial ability than Mg-MOF74. In conclusion, MgCu-MOF-74 with good water stability, osteogenic ability and antibacterial ability, which could be attributed to the doping of Cu 2+. Hence, MgCu-MOF74 shows great potential as a novel medical bio-functional fillers for the treatment of bone defects.
KW - Bacterial Infections
KW - Osteogenesis
KW - magnesium metal organic framework-74
KW - Metal-Organic Frameworks - pharmacology
KW - Anti-Bacterial Agents - chemistry
KW - Tissue Scaffolds - chemistry
KW - Humans
KW - copper
KW - Bone Regeneration
KW - bone repair
KW - osteogenesis
KW - antibacterial
KW - Water
U2 - 10.1088/1748-605X/aca24c
DO - 10.1088/1748-605X/aca24c
M3 - Journal article
C2 - 36368050
VL - 17
JO - Biomedical Materials
JF - Biomedical Materials
SN - 1748-6041
IS - 6
M1 - 065026
ER -