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Hippocampal activity during the transverse patterning task declines with cognitive competence but not with age

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Hippocampal activity during the transverse patterning task declines with cognitive competence but not with age. / Leirer, Vera Maria; Wienbruch, Christian; Paul-Jordanov, Isabella et al.
In: BMC Neuroscience, Vol. 11, 113, 2010.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Leirer, VM, Wienbruch, C, Paul-Jordanov, I, Kolassa, S, Elbert, T & Kolassa, IT 2010, 'Hippocampal activity during the transverse patterning task declines with cognitive competence but not with age', BMC Neuroscience, vol. 11, 113. https://doi.org/10.1186/1471-2202-11-113

APA

Leirer, V. M., Wienbruch, C., Paul-Jordanov, I., Kolassa, S., Elbert, T., & Kolassa, I. T. (2010). Hippocampal activity during the transverse patterning task declines with cognitive competence but not with age. BMC Neuroscience, 11, Article 113. https://doi.org/10.1186/1471-2202-11-113

Vancouver

Leirer VM, Wienbruch C, Paul-Jordanov I, Kolassa S, Elbert T, Kolassa IT. Hippocampal activity during the transverse patterning task declines with cognitive competence but not with age. BMC Neuroscience. 2010;11:113. doi: 10.1186/1471-2202-11-113

Author

Leirer, Vera Maria ; Wienbruch, Christian ; Paul-Jordanov, Isabella et al. / Hippocampal activity during the transverse patterning task declines with cognitive competence but not with age. In: BMC Neuroscience. 2010 ; Vol. 11.

Bibtex

@article{90009578d3fa46929e8f196a045b4075,
title = "Hippocampal activity during the transverse patterning task declines with cognitive competence but not with age",
abstract = "BackgroundThe hippocampus is a brain region that is particularly affected by age-related morphological changes. It is generally assumed that a loss in hippocampal volume results in functional deficits that contribute to age-related cognitive decline. In a combined cross-sectional behavioural and magnetoencephalography (MEG) study we investigated whether hippocampal-associated neural current flow during a transverse patterning task - which requires learning relational associations between stimuli - correlates with age and whether it is modulated by cognitive competence.ResultsBetter performance in several tests of verbal memory, verbal fluency and executive function was indeed associated with higher hippocampal neural activity. Age, however, was not related to the strength of hippocampal neural activity: elderly participants responded slower than younger individuals but on average produced the same neural mass activity.ConclusionsOur results suggest that in non-pathological aging, hippocampal neural activity does not decrease with age but is rather related to cognitive competence.",
author = "Leirer, {Vera Maria} and Christian Wienbruch and Isabella Paul-Jordanov and Stephan Kolassa and Thomas Elbert and Kolassa, {Iris- Tatjana}",
year = "2010",
doi = "10.1186/1471-2202-11-113",
language = "English",
volume = "11",
journal = "BMC Neuroscience",
issn = "1471-2202",
publisher = "BioMed Central",

}

RIS

TY - JOUR

T1 - Hippocampal activity during the transverse patterning task declines with cognitive competence but not with age

AU - Leirer, Vera Maria

AU - Wienbruch, Christian

AU - Paul-Jordanov, Isabella

AU - Kolassa, Stephan

AU - Elbert, Thomas

AU - Kolassa, Iris- Tatjana

PY - 2010

Y1 - 2010

N2 - BackgroundThe hippocampus is a brain region that is particularly affected by age-related morphological changes. It is generally assumed that a loss in hippocampal volume results in functional deficits that contribute to age-related cognitive decline. In a combined cross-sectional behavioural and magnetoencephalography (MEG) study we investigated whether hippocampal-associated neural current flow during a transverse patterning task - which requires learning relational associations between stimuli - correlates with age and whether it is modulated by cognitive competence.ResultsBetter performance in several tests of verbal memory, verbal fluency and executive function was indeed associated with higher hippocampal neural activity. Age, however, was not related to the strength of hippocampal neural activity: elderly participants responded slower than younger individuals but on average produced the same neural mass activity.ConclusionsOur results suggest that in non-pathological aging, hippocampal neural activity does not decrease with age but is rather related to cognitive competence.

AB - BackgroundThe hippocampus is a brain region that is particularly affected by age-related morphological changes. It is generally assumed that a loss in hippocampal volume results in functional deficits that contribute to age-related cognitive decline. In a combined cross-sectional behavioural and magnetoencephalography (MEG) study we investigated whether hippocampal-associated neural current flow during a transverse patterning task - which requires learning relational associations between stimuli - correlates with age and whether it is modulated by cognitive competence.ResultsBetter performance in several tests of verbal memory, verbal fluency and executive function was indeed associated with higher hippocampal neural activity. Age, however, was not related to the strength of hippocampal neural activity: elderly participants responded slower than younger individuals but on average produced the same neural mass activity.ConclusionsOur results suggest that in non-pathological aging, hippocampal neural activity does not decrease with age but is rather related to cognitive competence.

U2 - 10.1186/1471-2202-11-113

DO - 10.1186/1471-2202-11-113

M3 - Journal article

VL - 11

JO - BMC Neuroscience

JF - BMC Neuroscience

SN - 1471-2202

M1 - 113

ER -