Peste des petits ruminants virus infects a wide range of domestic and wild small ruminants and the host spectrum has recently increased to camels. Despite this host range, the clinical manifestation varies not only between domestic and wild small ruminants but also between different species. Studies have begun to reveal different host genetics and non-genetic factors that may play significant roles in disease outcome and virus susceptibility. The role of wild small ruminants in the epizootiology of PPRV is not fully understood, however, evidences indicate that these could play a role in disease transmission. Understanding these factors may be of help in disease control and eradication campaigns.