Sociological studies of sustainable transformation have highlighted the relevance of ‘unequal’ and ‘uneven’ transformation dynamics. We argue that a practice-based approach provides far more insight into such unequal dynamics than currently recognized. We re-interpret the political concepts of agonism, antagonism and historic bloc that Gramsci used to analyse domination in order to theorize practice constellations and dynamics that are responsible for the perpetuation of unsustainable practices and the suppression of sustainable ones. Based on empirical findings, we also expand his vocabulary by introducing the concept of synergy. Using the example of urban cycling in Las Palmas de Gran Canaria, we propose a Gramscian-inspired account of power and domination in practices as a way of understanding inequality in transformation efforts.