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Hypertension drives parenchymal β-amyloid accumulation in the brain parenchyma

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Hypertension drives parenchymal β-amyloid accumulation in the brain parenchyma. / Bueche, Celine Z.; Hawkes, Cheryl; Garz, Cornelia et al.
In: Annals of Clinical and Translational Neurology, Vol. 1, No. 2, 01.01.2014, p. 124-129.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Bueche, CZ, Hawkes, C, Garz, C, Vielhaber, S, Attems, J, Knight, RT, Reymann, K, Heinze, HJ, Carare, RO & Schreiber, S 2014, 'Hypertension drives parenchymal β-amyloid accumulation in the brain parenchyma', Annals of Clinical and Translational Neurology, vol. 1, no. 2, pp. 124-129. https://doi.org/10.1002/acn3.27

APA

Bueche, C. Z., Hawkes, C., Garz, C., Vielhaber, S., Attems, J., Knight, R. T., Reymann, K., Heinze, H. J., Carare, R. O., & Schreiber, S. (2014). Hypertension drives parenchymal β-amyloid accumulation in the brain parenchyma. Annals of Clinical and Translational Neurology, 1(2), 124-129. https://doi.org/10.1002/acn3.27

Vancouver

Bueche CZ, Hawkes C, Garz C, Vielhaber S, Attems J, Knight RT et al. Hypertension drives parenchymal β-amyloid accumulation in the brain parenchyma. Annals of Clinical and Translational Neurology. 2014 Jan 1;1(2):124-129. doi: 10.1002/acn3.27

Author

Bueche, Celine Z. ; Hawkes, Cheryl ; Garz, Cornelia et al. / Hypertension drives parenchymal β-amyloid accumulation in the brain parenchyma. In: Annals of Clinical and Translational Neurology. 2014 ; Vol. 1, No. 2. pp. 124-129.

Bibtex

@article{8b84cdd62a3146029d1d28bd91df60c2,
title = "Hypertension drives parenchymal β-amyloid accumulation in the brain parenchyma",
abstract = "There is substantial controversy regarding the causative role of amyloid β (Aβ) deposition in Alzheimer's disease (AD). The cerebrovasculature plays an important role in the elimination of Ab from the brain and hypertension is a wellknown risk factor for AD. In spontaneously hypertensive stroke-prone rats (SHRSP), an animal model of chronic arterial hypertension, cerebral small vessel disease (CSVD) leads to age-dependent parenchymal Aβ accumulation similar to that observed in AD. These data approve the neuropathological link between CSVD and AD, confirm the challenge that parenchymal Aβ deposition is a specific marker for AD and disclose the meaning of SHRSP as valid experimental model to investigate the association between hypertension, CSVD, and Aβ plaques.",
author = "Bueche, {Celine Z.} and Cheryl Hawkes and Cornelia Garz and Stefan Vielhaber and Johannes Attems and Knight, {Robert T.} and Klaus Reymann and Heinze, {Hans Jochen} and Carare, {Roxana O.} and Stefanie Schreiber",
year = "2014",
month = jan,
day = "1",
doi = "10.1002/acn3.27",
language = "English",
volume = "1",
pages = "124--129",
journal = "Annals of Clinical and Translational Neurology",
issn = "2328-9503",
publisher = "John Wiley and Sons Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Hypertension drives parenchymal β-amyloid accumulation in the brain parenchyma

AU - Bueche, Celine Z.

AU - Hawkes, Cheryl

AU - Garz, Cornelia

AU - Vielhaber, Stefan

AU - Attems, Johannes

AU - Knight, Robert T.

AU - Reymann, Klaus

AU - Heinze, Hans Jochen

AU - Carare, Roxana O.

AU - Schreiber, Stefanie

PY - 2014/1/1

Y1 - 2014/1/1

N2 - There is substantial controversy regarding the causative role of amyloid β (Aβ) deposition in Alzheimer's disease (AD). The cerebrovasculature plays an important role in the elimination of Ab from the brain and hypertension is a wellknown risk factor for AD. In spontaneously hypertensive stroke-prone rats (SHRSP), an animal model of chronic arterial hypertension, cerebral small vessel disease (CSVD) leads to age-dependent parenchymal Aβ accumulation similar to that observed in AD. These data approve the neuropathological link between CSVD and AD, confirm the challenge that parenchymal Aβ deposition is a specific marker for AD and disclose the meaning of SHRSP as valid experimental model to investigate the association between hypertension, CSVD, and Aβ plaques.

AB - There is substantial controversy regarding the causative role of amyloid β (Aβ) deposition in Alzheimer's disease (AD). The cerebrovasculature plays an important role in the elimination of Ab from the brain and hypertension is a wellknown risk factor for AD. In spontaneously hypertensive stroke-prone rats (SHRSP), an animal model of chronic arterial hypertension, cerebral small vessel disease (CSVD) leads to age-dependent parenchymal Aβ accumulation similar to that observed in AD. These data approve the neuropathological link between CSVD and AD, confirm the challenge that parenchymal Aβ deposition is a specific marker for AD and disclose the meaning of SHRSP as valid experimental model to investigate the association between hypertension, CSVD, and Aβ plaques.

U2 - 10.1002/acn3.27

DO - 10.1002/acn3.27

M3 - Journal article

AN - SCOPUS:84920583023

VL - 1

SP - 124

EP - 129

JO - Annals of Clinical and Translational Neurology

JF - Annals of Clinical and Translational Neurology

SN - 2328-9503

IS - 2

ER -