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Identification and efficacy of longitudinal markers for survival.

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Identification and efficacy of longitudinal markers for survival. / Henderson, Robin; Diggle, Peter J.; Dobson, Angela.
In: Biostatistics, Vol. 3, No. 1, 03.2002, p. 33-50.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Henderson, R, Diggle, PJ & Dobson, A 2002, 'Identification and efficacy of longitudinal markers for survival.', Biostatistics, vol. 3, no. 1, pp. 33-50. https://doi.org/10.1093/biostatistics/3.1.33

APA

Henderson, R., Diggle, P. J., & Dobson, A. (2002). Identification and efficacy of longitudinal markers for survival. Biostatistics, 3(1), 33-50. https://doi.org/10.1093/biostatistics/3.1.33

Vancouver

Henderson R, Diggle PJ, Dobson A. Identification and efficacy of longitudinal markers for survival. Biostatistics. 2002 Mar;3(1):33-50. doi: 10.1093/biostatistics/3.1.33

Author

Henderson, Robin ; Diggle, Peter J. ; Dobson, Angela. / Identification and efficacy of longitudinal markers for survival. In: Biostatistics. 2002 ; Vol. 3, No. 1. pp. 33-50.

Bibtex

@article{2eb09ce011354b14a21d6379a4ca5c47,
title = "Identification and efficacy of longitudinal markers for survival.",
abstract = "Methods for the combined analysis of survival time and longitudinal biomarker data have been developed in recent years, with most emphasis on modelling and estimation. This paper focuses on the use of longitudinal marker trajectories as individual-level surrogates for survival. A score test for association which requires only standard methods for implementation is derived for the initial identification of candidate biomarkers. Methods for assessing efficacy of markers are discussed and a measure contrasting conditional and marginal distibutions is proposed. An application using prothrombin index as biomarker for survival of liver cirrhosis patients is included.",
keywords = "Explained variation, Joint modelling, Residual lifetime distribution, Score test, Surrogates",
author = "Robin Henderson and Diggle, {Peter J.} and Angela Dobson",
year = "2002",
month = mar,
doi = "10.1093/biostatistics/3.1.33",
language = "English",
volume = "3",
pages = "33--50",
journal = "Biostatistics",
issn = "1468-4357",
publisher = "Oxford University Press",
number = "1",

}

RIS

TY - JOUR

T1 - Identification and efficacy of longitudinal markers for survival.

AU - Henderson, Robin

AU - Diggle, Peter J.

AU - Dobson, Angela

PY - 2002/3

Y1 - 2002/3

N2 - Methods for the combined analysis of survival time and longitudinal biomarker data have been developed in recent years, with most emphasis on modelling and estimation. This paper focuses on the use of longitudinal marker trajectories as individual-level surrogates for survival. A score test for association which requires only standard methods for implementation is derived for the initial identification of candidate biomarkers. Methods for assessing efficacy of markers are discussed and a measure contrasting conditional and marginal distibutions is proposed. An application using prothrombin index as biomarker for survival of liver cirrhosis patients is included.

AB - Methods for the combined analysis of survival time and longitudinal biomarker data have been developed in recent years, with most emphasis on modelling and estimation. This paper focuses on the use of longitudinal marker trajectories as individual-level surrogates for survival. A score test for association which requires only standard methods for implementation is derived for the initial identification of candidate biomarkers. Methods for assessing efficacy of markers are discussed and a measure contrasting conditional and marginal distibutions is proposed. An application using prothrombin index as biomarker for survival of liver cirrhosis patients is included.

KW - Explained variation

KW - Joint modelling

KW - Residual lifetime distribution

KW - Score test

KW - Surrogates

U2 - 10.1093/biostatistics/3.1.33

DO - 10.1093/biostatistics/3.1.33

M3 - Journal article

VL - 3

SP - 33

EP - 50

JO - Biostatistics

JF - Biostatistics

SN - 1468-4357

IS - 1

ER -