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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Identifying Plasmodium falciparum transmission patterns through parasite prevalence and entomological inoculation rate
AU - Amoah, Benjamin
AU - McCann, Robert S.
AU - Kabaghe, Alinune N.
AU - Mburu, Monicah M
AU - Chipeta, Michael G.
AU - Moraga, Paula
AU - Gowelo, Steven
AU - Tizifa, T.
AU - van den Berg, Henk
AU - Mzilahowa, Themba
AU - Takken, Willem
AU - van Vugt, Michèle
AU - Phiri, Kamija S.
AU - Diggle, Peter
AU - Terlouw, Dianne J.
AU - Giorgi, Emanuele
PY - 2021/10/21
Y1 - 2021/10/21
N2 - Background: Monitoring malaria transmission is a critical component of efforts to achieve targets for elimination and eradication. Two commonly monitored metrics of transmission intensity are parasite prevalence (PR) and the entomological inoculation rate (EIR). Comparing the spatial and temporal variations in the PR and EIR of a given geographical region and modelling the relationship between the two metrics may provide a fuller picture of the malaria epidemiology of the region to inform control activities.Methods: Using geostatistical methods, we compare the spatial and temporal patterns of Plasmodium falciparum EIR and PR using data collected over 38 months in a rural area of Malawi.We then quantify the relationship between EIR and PR by using empirical and mechanistic statistical models.Results: Hotspots identified through the EIR and PR partly overlapped during high transmission seasons but not during low transmission seasons. The estimated relationship showed a 1-month delayed effect of EIR on PR such that at lower levels of EIR, increases in EIR are associated with rapid rise in PR, whereas at higher levels of EIR, changes in EIR do not translate into notable changes in PR.Conclusions: Our study emphasises the need for integrated malaria control strategies that combine vector and human host managements monitored by both entomological and parasitaemia indices.
AB - Background: Monitoring malaria transmission is a critical component of efforts to achieve targets for elimination and eradication. Two commonly monitored metrics of transmission intensity are parasite prevalence (PR) and the entomological inoculation rate (EIR). Comparing the spatial and temporal variations in the PR and EIR of a given geographical region and modelling the relationship between the two metrics may provide a fuller picture of the malaria epidemiology of the region to inform control activities.Methods: Using geostatistical methods, we compare the spatial and temporal patterns of Plasmodium falciparum EIR and PR using data collected over 38 months in a rural area of Malawi.We then quantify the relationship between EIR and PR by using empirical and mechanistic statistical models.Results: Hotspots identified through the EIR and PR partly overlapped during high transmission seasons but not during low transmission seasons. The estimated relationship showed a 1-month delayed effect of EIR on PR such that at lower levels of EIR, increases in EIR are associated with rapid rise in PR, whereas at higher levels of EIR, changes in EIR do not translate into notable changes in PR.Conclusions: Our study emphasises the need for integrated malaria control strategies that combine vector and human host managements monitored by both entomological and parasitaemia indices.
U2 - 10.7554/eLife.65682
DO - 10.7554/eLife.65682
M3 - Journal article
VL - 2021
JO - eLife
JF - eLife
SN - 2050-084X
M1 - e65682
ER -