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ILC2 orchestration of local immune function in adipose tissue: ILC2 orchestration of immune adipose function

Research output: Contribution to Journal/Magazine › Review article › peer-review

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ILC2 orchestration of local immune function in adipose tissue: ILC2 orchestration of immune adipose function. / Benezech, Cecile; Jackson-Jones, Lucy.
In: Frontiers in Immunology, Vol. 10, 171, 07.02.2019.

Research output: Contribution to Journal/Magazine › Review article › peer-review

Harvard

Benezech, C & Jackson-Jones, L 2019, 'ILC2 orchestration of local immune function in adipose tissue: ILC2 orchestration of immune adipose function', Frontiers in Immunology, vol. 10, 171. https://doi.org/10.3389/fimmu.2019.00171

APA

Benezech, C., & Jackson-Jones, L. (2019). ILC2 orchestration of local immune function in adipose tissue: ILC2 orchestration of immune adipose function. Frontiers in Immunology, 10, Article 171. https://doi.org/10.3389/fimmu.2019.00171

Vancouver

Benezech C, Jackson-Jones L. ILC2 orchestration of local immune function in adipose tissue: ILC2 orchestration of immune adipose function. Frontiers in Immunology. 2019 Feb 7;10:171. doi: 10.3389/fimmu.2019.00171

Author

Benezech, Cecile ; Jackson-Jones, Lucy. / ILC2 orchestration of local immune function in adipose tissue : ILC2 orchestration of immune adipose function. In: Frontiers in Immunology. 2019 ; Vol. 10.

Bibtex

@article{d14d2ae480024e4fbca021da9e3e48ed,
title = "ILC2 orchestration of local immune function in adipose tissue: ILC2 orchestration of immune adipose function",
abstract = "ILC2s were originally identified as IL-5 and IL-13 secreting {\textquoteleft}natural helper cells{\textquoteright} present within the fat associated lymphoid clusters of the mesenteries in both mouse and man. The presence of ILCs in adipose tissue has more recently expanded to include all ILC groups. Since their initial discovery, our knowledge of these cells and their role in adipose immune responses has expanded significantly. In this review we summarise the current literature on the role that ILC2s play in orchestrating adipose tissue function in both lean and obese states. We go on to address new data detailing interactions of adipose ILCs with innate like B-cells (IBC) and discuss how this interaction results in localised protection of mucosal sites during infection and inflammation via the production of innate antibodies. ",
keywords = "adipose, ILC2, FALCs, innate, antibodies, thermogenesis, mucosal, atherosclerosis",
author = "Cecile Benezech and Lucy Jackson-Jones",
year = "2019",
month = feb,
day = "7",
doi = "10.3389/fimmu.2019.00171",
language = "English",
volume = "10",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - ILC2 orchestration of local immune function in adipose tissue

T2 - ILC2 orchestration of immune adipose function

AU - Benezech, Cecile

AU - Jackson-Jones, Lucy

PY - 2019/2/7

Y1 - 2019/2/7

N2 - ILC2s were originally identified as IL-5 and IL-13 secreting ‘natural helper cells’ present within the fat associated lymphoid clusters of the mesenteries in both mouse and man. The presence of ILCs in adipose tissue has more recently expanded to include all ILC groups. Since their initial discovery, our knowledge of these cells and their role in adipose immune responses has expanded significantly. In this review we summarise the current literature on the role that ILC2s play in orchestrating adipose tissue function in both lean and obese states. We go on to address new data detailing interactions of adipose ILCs with innate like B-cells (IBC) and discuss how this interaction results in localised protection of mucosal sites during infection and inflammation via the production of innate antibodies.

AB - ILC2s were originally identified as IL-5 and IL-13 secreting ‘natural helper cells’ present within the fat associated lymphoid clusters of the mesenteries in both mouse and man. The presence of ILCs in adipose tissue has more recently expanded to include all ILC groups. Since their initial discovery, our knowledge of these cells and their role in adipose immune responses has expanded significantly. In this review we summarise the current literature on the role that ILC2s play in orchestrating adipose tissue function in both lean and obese states. We go on to address new data detailing interactions of adipose ILCs with innate like B-cells (IBC) and discuss how this interaction results in localised protection of mucosal sites during infection and inflammation via the production of innate antibodies.

KW - adipose

KW - ILC2

KW - FALCs

KW - innate

KW - antibodies

KW - thermogenesis

KW - mucosal

KW - atherosclerosis

U2 - 10.3389/fimmu.2019.00171

DO - 10.3389/fimmu.2019.00171

M3 - Review article

VL - 10

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

M1 - 171

ER -