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Immunogold labeling of cerebrovascular and neuritic plaque amyloid fibrils in Alzheimer's disease with an anti-β protein monoclonal antibody

Research output: Contribution to Journal/MagazineJournal articlepeer-review

  • S Ikeda
  • C W Wong
  • D Allsop
  • M Landon
  • M Kidd
  • G G Glenner
<mark>Journal publication date</mark>1987
<mark>Journal</mark>Laboratory Investigation
Issue number4
Number of pages4
Pages (from-to)446-9
Publication StatusPublished
<mark>Original language</mark>English


A monoclonal antibody raised to a synthetic peptide consisting of residues 8 to 17 of the amyloid beta protein of Alzheimer's disease was employed for immunogold electron microscopic studies on amyloid fibrils of cerebrovascular walls and neuritic plaques in this disease. Electron microscopy revealed a specific gold labeling of the amyloid fibrils in these structures. This provides ultrastructural evidence that beta protein is intimately associated with the amyloid fibril. With previous chemical evidence, this observation supports the concentration that it is an intrinsic component of the fibril.