Immunogold labeling of cerebrovascular and neuritic plaque amyloid fibrils in Alzheimer's disease with an anti-β protein monoclonal antibody

Biomedical and Life Sciences

Keywords

Alzheimer Disease, Amyloid, Amyloid beta-Peptides, Antibodies, Monoclonal, Humans, Immunoenzyme Techniques, Immunohistochemistry, Microscopy, Electron, Neurofibrils

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Immunogold labeling of cerebrovascular and neuritic plaque amyloid fibrils in Alzheimer's disease with an anti-β protein monoclonal antibody. / Ikeda, S; Wong, C W; Allsop, D et al.
In: Laboratory Investigation, Vol. 57, No. 4, 1987, p. 446-9.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Bibtex

@article{6cf1275807a44145ab8a8c32c89fcb1c,

title = "Immunogold labeling of cerebrovascular and neuritic plaque amyloid fibrils in Alzheimer's disease with an anti-β protein monoclonal antibody",

abstract = "A monoclonal antibody raised to a synthetic peptide consisting of residues 8 to 17 of the amyloid beta protein of Alzheimer's disease was employed for immunogold electron microscopic studies on amyloid fibrils of cerebrovascular walls and neuritic plaques in this disease. Electron microscopy revealed a specific gold labeling of the amyloid fibrils in these structures. This provides ultrastructural evidence that beta protein is intimately associated with the amyloid fibril. With previous chemical evidence, this observation supports the concentration that it is an intrinsic component of the fibril.",

keywords = "Alzheimer Disease, Amyloid, Amyloid beta-Peptides, Antibodies, Monoclonal, Humans, Immunoenzyme Techniques, Immunohistochemistry, Microscopy, Electron, Neurofibrils",

author = "S Ikeda and Wong, {C W} and D Allsop and M Landon and M Kidd and Glenner, {G G}",

year = "1987",

language = "English",

volume = "57",

pages = "446--9",

journal = "Laboratory Investigation",

issn = "0023-6837",

publisher = "Nature Publishing Group",

number = "4",

}

RIS

TY - JOUR

T1 - Immunogold labeling of cerebrovascular and neuritic plaque amyloid fibrils in Alzheimer's disease with an anti-β protein monoclonal antibody

AU - Ikeda, S

AU - Wong, C W

AU - Allsop, D

AU - Landon, M

AU - Kidd, M

AU - Glenner, G G

PY - 1987

Y1 - 1987

N2 - A monoclonal antibody raised to a synthetic peptide consisting of residues 8 to 17 of the amyloid beta protein of Alzheimer's disease was employed for immunogold electron microscopic studies on amyloid fibrils of cerebrovascular walls and neuritic plaques in this disease. Electron microscopy revealed a specific gold labeling of the amyloid fibrils in these structures. This provides ultrastructural evidence that beta protein is intimately associated with the amyloid fibril. With previous chemical evidence, this observation supports the concentration that it is an intrinsic component of the fibril.

AB - A monoclonal antibody raised to a synthetic peptide consisting of residues 8 to 17 of the amyloid beta protein of Alzheimer's disease was employed for immunogold electron microscopic studies on amyloid fibrils of cerebrovascular walls and neuritic plaques in this disease. Electron microscopy revealed a specific gold labeling of the amyloid fibrils in these structures. This provides ultrastructural evidence that beta protein is intimately associated with the amyloid fibril. With previous chemical evidence, this observation supports the concentration that it is an intrinsic component of the fibril.

KW - Alzheimer Disease

KW - Amyloid

KW - Amyloid beta-Peptides

KW - Antibodies, Monoclonal

KW - Humans

KW - Immunoenzyme Techniques

KW - Immunohistochemistry

KW - Microscopy, Electron

KW - Neurofibrils

M3 - Journal article

C2 - 3312810

VL - 57

SP - 446

EP - 449

JO - Laboratory Investigation

JF - Laboratory Investigation

SN - 0023-6837

IS - 4

ER -

Research

Keywords