Home > Research > Publications & Outputs > Incipient cardiovascular autonomic imbalance re...
View graph of relations

Incipient cardiovascular autonomic imbalance revealed by wavelet analysis of heart rate variability in Type 2 diabetic patients.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Published

Standard

Incipient cardiovascular autonomic imbalance revealed by wavelet analysis of heart rate variability in Type 2 diabetic patients. / Urbančič-Rovan, Vilma; Meglič, Bernard; Stefanovska, Aneta et al.
In: Diabetic Medicine, Vol. 24, No. 1, 01.2007, p. 18-26.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

APA

Vancouver

Urbančič-Rovan V, Meglič B, Stefanovska A, Bernjak A, Ažman-Juvan K, Kocijančič A. Incipient cardiovascular autonomic imbalance revealed by wavelet analysis of heart rate variability in Type 2 diabetic patients. Diabetic Medicine. 2007 Jan;24(1):18-26. doi: 10.1111/j.1464-5491.2007.02019.x

Author

Urbančič-Rovan, Vilma ; Meglič, Bernard ; Stefanovska, Aneta et al. / Incipient cardiovascular autonomic imbalance revealed by wavelet analysis of heart rate variability in Type 2 diabetic patients. In: Diabetic Medicine. 2007 ; Vol. 24, No. 1. pp. 18-26.

Bibtex

@article{14b221698ccd4a41ae060fb2a0cbbc88,
title = "Incipient cardiovascular autonomic imbalance revealed by wavelet analysis of heart rate variability in Type 2 diabetic patients.",
abstract = "Abstract Aim Incipient cardiovascular autonomic imbalance is not readily diagnosed by conventional methods. Spectral analysis of heart rate variability (HRV) by wavelet transform (WT) was used to measure cardiovascular autonomic function in patients with Type 2 diabetes. Methods Thirty-two diabetic patients without (D), 26 with cardiovascular autonomic neuropathy (DAN) and 72 control subjects (C) participated. A 30-min HRV time series was analysed by wavelet transformation and four characteristic frequency intervals were defined: I (0.0095–0.021 Hz), II (0.021–0.052 Hz), III (0.052–0.145 Hz) and IV (0.145–0.6 Hz). Results When compared with C, in both D and DAN the normalized power and amplitude of interval II were increased and of interval IV decreased, resulting in a significantly higher II/IV ratio. Furthermore, in DAN the normalized power and amplitude of interval I were increased and of interval III decreased when compared with the D and C groups. The diabetic patients were divided in two equal subgroups according to HbA1c < 8.0% and ≥ 8.0%. In the subgroup with HbA 1c ≥ 8.0%, normalized power in interval II was significantly higher and in interval IV significantly lower than in the subgroup with HbA 1c < 8.0%. In D, but not in DAN patients prescribed ACE inhibitors, the absolute amplitude and power of oscillations were significantly higher than in patients not taking ACE inhibitor therapy. Conclusions Patients with diabetes have increased sympathetic and decreased parasympathetic cardiac activity regardless of the presence of autonomic neuropathy. Glycaemic control and treatment with ACE inhibitors may favourably influence HRV in diabetic patients without autonomic neuropathy.",
keywords = "autonomic nervous system • cardiac autonomic neuropathy • heart rate variability • non-linear dynamics",
author = "Vilma Urban{\v c}i{\v c}-Rovan and Bernard Megli{\v c} and Aneta Stefanovska and Alan Bernjak and Katja A{\v z}man-Juvan and Andreja Kocijan{\v c}i{\v c}",
year = "2007",
month = jan,
doi = "10.1111/j.1464-5491.2007.02019.x",
language = "English",
volume = "24",
pages = "18--26",
journal = "Diabetic Medicine",
issn = "0742-3071",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Incipient cardiovascular autonomic imbalance revealed by wavelet analysis of heart rate variability in Type 2 diabetic patients.

AU - Urbančič-Rovan, Vilma

AU - Meglič, Bernard

AU - Stefanovska, Aneta

AU - Bernjak, Alan

AU - Ažman-Juvan, Katja

AU - Kocijančič, Andreja

PY - 2007/1

Y1 - 2007/1

N2 - Abstract Aim Incipient cardiovascular autonomic imbalance is not readily diagnosed by conventional methods. Spectral analysis of heart rate variability (HRV) by wavelet transform (WT) was used to measure cardiovascular autonomic function in patients with Type 2 diabetes. Methods Thirty-two diabetic patients without (D), 26 with cardiovascular autonomic neuropathy (DAN) and 72 control subjects (C) participated. A 30-min HRV time series was analysed by wavelet transformation and four characteristic frequency intervals were defined: I (0.0095–0.021 Hz), II (0.021–0.052 Hz), III (0.052–0.145 Hz) and IV (0.145–0.6 Hz). Results When compared with C, in both D and DAN the normalized power and amplitude of interval II were increased and of interval IV decreased, resulting in a significantly higher II/IV ratio. Furthermore, in DAN the normalized power and amplitude of interval I were increased and of interval III decreased when compared with the D and C groups. The diabetic patients were divided in two equal subgroups according to HbA1c < 8.0% and ≥ 8.0%. In the subgroup with HbA 1c ≥ 8.0%, normalized power in interval II was significantly higher and in interval IV significantly lower than in the subgroup with HbA 1c < 8.0%. In D, but not in DAN patients prescribed ACE inhibitors, the absolute amplitude and power of oscillations were significantly higher than in patients not taking ACE inhibitor therapy. Conclusions Patients with diabetes have increased sympathetic and decreased parasympathetic cardiac activity regardless of the presence of autonomic neuropathy. Glycaemic control and treatment with ACE inhibitors may favourably influence HRV in diabetic patients without autonomic neuropathy.

AB - Abstract Aim Incipient cardiovascular autonomic imbalance is not readily diagnosed by conventional methods. Spectral analysis of heart rate variability (HRV) by wavelet transform (WT) was used to measure cardiovascular autonomic function in patients with Type 2 diabetes. Methods Thirty-two diabetic patients without (D), 26 with cardiovascular autonomic neuropathy (DAN) and 72 control subjects (C) participated. A 30-min HRV time series was analysed by wavelet transformation and four characteristic frequency intervals were defined: I (0.0095–0.021 Hz), II (0.021–0.052 Hz), III (0.052–0.145 Hz) and IV (0.145–0.6 Hz). Results When compared with C, in both D and DAN the normalized power and amplitude of interval II were increased and of interval IV decreased, resulting in a significantly higher II/IV ratio. Furthermore, in DAN the normalized power and amplitude of interval I were increased and of interval III decreased when compared with the D and C groups. The diabetic patients were divided in two equal subgroups according to HbA1c < 8.0% and ≥ 8.0%. In the subgroup with HbA 1c ≥ 8.0%, normalized power in interval II was significantly higher and in interval IV significantly lower than in the subgroup with HbA 1c < 8.0%. In D, but not in DAN patients prescribed ACE inhibitors, the absolute amplitude and power of oscillations were significantly higher than in patients not taking ACE inhibitor therapy. Conclusions Patients with diabetes have increased sympathetic and decreased parasympathetic cardiac activity regardless of the presence of autonomic neuropathy. Glycaemic control and treatment with ACE inhibitors may favourably influence HRV in diabetic patients without autonomic neuropathy.

KW - autonomic nervous system • cardiac autonomic neuropathy • heart rate variability • non-linear dynamics

U2 - 10.1111/j.1464-5491.2007.02019.x

DO - 10.1111/j.1464-5491.2007.02019.x

M3 - Journal article

VL - 24

SP - 18

EP - 26

JO - Diabetic Medicine

JF - Diabetic Medicine

SN - 0742-3071

IS - 1

ER -