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Incorporating data received after a sequential trial has stopped into the final analysis: implementation and comparison of methods.

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Incorporating data received after a sequential trial has stopped into the final analysis: implementation and comparison of methods. / Whitehead, John; Bollard, Kim; Matsushita, Tatsuru; Sooriyarachchi, Marina Roshini; Whitehead, Anne.

In: Biometrics, Vol. 59, No. 3, 09.2003, p. 701-709.

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Whitehead, John ; Bollard, Kim ; Matsushita, Tatsuru ; Sooriyarachchi, Marina Roshini ; Whitehead, Anne. / Incorporating data received after a sequential trial has stopped into the final analysis: implementation and comparison of methods. In: Biometrics. 2003 ; Vol. 59, No. 3. pp. 701-709.

Bibtex

@article{df2ce975be1d445aa1b0b9ef3a378747,
title = "Incorporating data received after a sequential trial has stopped into the final analysis: implementation and comparison of methods.",
abstract = "In a sequential clinical trial, accrual of data on patients often continues after the stopping criterion for the study has been met. This is termed {"}overrunning.{"} Overrunning occurs mainly when the primary response from each patient is measured after some extended observation period. The objective of this article is to compare two methods of allowing for overrunning. In particular, simulation studies are reported that assess the two procedures in terms of how well they maintain the intended type I error rate. The effect on power resulting from the incorporation of {"}overrunning data{"} using the two procedures is evaluated.",
author = "John Whitehead and Kim Bollard and Tatsuru Matsushita and Sooriyarachchi, {Marina Roshini} and Anne Whitehead",
note = "RAE_import_type : Journal article RAE_uoa_type : Statistics and Operational Research",
year = "2003",
month = sep,
doi = "10.1111/1541-0420.00081",
language = "English",
volume = "59",
pages = "701--709",
journal = "Biometrics",
issn = "0006-341X",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Incorporating data received after a sequential trial has stopped into the final analysis: implementation and comparison of methods.

AU - Whitehead, John

AU - Bollard, Kim

AU - Matsushita, Tatsuru

AU - Sooriyarachchi, Marina Roshini

AU - Whitehead, Anne

N1 - RAE_import_type : Journal article RAE_uoa_type : Statistics and Operational Research

PY - 2003/9

Y1 - 2003/9

N2 - In a sequential clinical trial, accrual of data on patients often continues after the stopping criterion for the study has been met. This is termed "overrunning." Overrunning occurs mainly when the primary response from each patient is measured after some extended observation period. The objective of this article is to compare two methods of allowing for overrunning. In particular, simulation studies are reported that assess the two procedures in terms of how well they maintain the intended type I error rate. The effect on power resulting from the incorporation of "overrunning data" using the two procedures is evaluated.

AB - In a sequential clinical trial, accrual of data on patients often continues after the stopping criterion for the study has been met. This is termed "overrunning." Overrunning occurs mainly when the primary response from each patient is measured after some extended observation period. The objective of this article is to compare two methods of allowing for overrunning. In particular, simulation studies are reported that assess the two procedures in terms of how well they maintain the intended type I error rate. The effect on power resulting from the incorporation of "overrunning data" using the two procedures is evaluated.

U2 - 10.1111/1541-0420.00081

DO - 10.1111/1541-0420.00081

M3 - Journal article

VL - 59

SP - 701

EP - 709

JO - Biometrics

JF - Biometrics

SN - 0006-341X

IS - 3

ER -