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Increased Aβ pathology in aged Tg2576 mice born to mothers fed a high fat diet

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Increased Aβ pathology in aged Tg2576 mice born to mothers fed a high fat diet. / Nizari, Shereen; Carare, Roxana O.; Hawkes, Cheryl A.
In: Scientific Reports, Vol. 6, 21981, 25.02.2016.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Nizari, S, Carare, RO & Hawkes, CA 2016, 'Increased Aβ pathology in aged Tg2576 mice born to mothers fed a high fat diet', Scientific Reports, vol. 6, 21981. https://doi.org/10.1038/srep21981

APA

Nizari, S., Carare, R. O., & Hawkes, C. A. (2016). Increased Aβ pathology in aged Tg2576 mice born to mothers fed a high fat diet. Scientific Reports, 6, Article 21981. https://doi.org/10.1038/srep21981

Vancouver

Nizari S, Carare RO, Hawkes CA. Increased Aβ pathology in aged Tg2576 mice born to mothers fed a high fat diet. Scientific Reports. 2016 Feb 25;6:21981. doi: 10.1038/srep21981

Author

Nizari, Shereen ; Carare, Roxana O. ; Hawkes, Cheryl A. / Increased Aβ pathology in aged Tg2576 mice born to mothers fed a high fat diet. In: Scientific Reports. 2016 ; Vol. 6.

Bibtex

@article{72d8add2bdaa478fae2a0628808ba7a1,
title = "Increased Aβ pathology in aged Tg2576 mice born to mothers fed a high fat diet",
abstract = "Maternal obesity is associated with increased risk of developing diabetes, obesity and premature death in adult offspring. Mid-life diabetes, hypertension and hypercholesterolaemia are risk factors for the development of sporadic Alzheimer's disease (AD). A key pathogenic feature of AD is the accumulation of β-amyloid (Aβ) in the brain. The purpose of this study was to investigate the effect of high fat diet feeding during early life on Aβ pathology in the Tg2576 mouse model of AD. Female mice were fed a standard (C) or high fat (HF) diet before mating and during gestation and lactation. At weaning, male offspring were fed a C diet. Significantly higher levels of guanidine-soluble Aβ and plaque loads were observed in the hippocampi of 11-month old Tg2576 mice born to mothers fed a HF diet. Changes in the extracellular matrix led to increased retention of Aβ within the parenchyma. These data support a role for maternal and gestational health on the health of the aged brain and pathologies associated with AD and may provide a novel target for both the prevention and treatment of AD.",
author = "Shereen Nizari and Carare, {Roxana O.} and Hawkes, {Cheryl A.}",
year = "2016",
month = feb,
day = "25",
doi = "10.1038/srep21981",
language = "English",
volume = "6",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Increased Aβ pathology in aged Tg2576 mice born to mothers fed a high fat diet

AU - Nizari, Shereen

AU - Carare, Roxana O.

AU - Hawkes, Cheryl A.

PY - 2016/2/25

Y1 - 2016/2/25

N2 - Maternal obesity is associated with increased risk of developing diabetes, obesity and premature death in adult offspring. Mid-life diabetes, hypertension and hypercholesterolaemia are risk factors for the development of sporadic Alzheimer's disease (AD). A key pathogenic feature of AD is the accumulation of β-amyloid (Aβ) in the brain. The purpose of this study was to investigate the effect of high fat diet feeding during early life on Aβ pathology in the Tg2576 mouse model of AD. Female mice were fed a standard (C) or high fat (HF) diet before mating and during gestation and lactation. At weaning, male offspring were fed a C diet. Significantly higher levels of guanidine-soluble Aβ and plaque loads were observed in the hippocampi of 11-month old Tg2576 mice born to mothers fed a HF diet. Changes in the extracellular matrix led to increased retention of Aβ within the parenchyma. These data support a role for maternal and gestational health on the health of the aged brain and pathologies associated with AD and may provide a novel target for both the prevention and treatment of AD.

AB - Maternal obesity is associated with increased risk of developing diabetes, obesity and premature death in adult offspring. Mid-life diabetes, hypertension and hypercholesterolaemia are risk factors for the development of sporadic Alzheimer's disease (AD). A key pathogenic feature of AD is the accumulation of β-amyloid (Aβ) in the brain. The purpose of this study was to investigate the effect of high fat diet feeding during early life on Aβ pathology in the Tg2576 mouse model of AD. Female mice were fed a standard (C) or high fat (HF) diet before mating and during gestation and lactation. At weaning, male offspring were fed a C diet. Significantly higher levels of guanidine-soluble Aβ and plaque loads were observed in the hippocampi of 11-month old Tg2576 mice born to mothers fed a HF diet. Changes in the extracellular matrix led to increased retention of Aβ within the parenchyma. These data support a role for maternal and gestational health on the health of the aged brain and pathologies associated with AD and may provide a novel target for both the prevention and treatment of AD.

U2 - 10.1038/srep21981

DO - 10.1038/srep21981

M3 - Journal article

C2 - 26911528

AN - SCOPUS:84959432459

VL - 6

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 21981

ER -