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Induction of innate immunity and its perturbation by influenza viruses

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Induction of innate immunity and its perturbation by influenza viruses. / Goraya, Mohsan Ullah; Wang, Song; Munir, Muhammad et al.
In: Protein and Cell, Vol. 6, No. 10, 10.2015, p. 712-721.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Goraya, MU, Wang, S, Munir, M & Chen, J-L 2015, 'Induction of innate immunity and its perturbation by influenza viruses', Protein and Cell, vol. 6, no. 10, pp. 712-721. https://doi.org/10.1007/s13238-015-0191-z

APA

Goraya, M. U., Wang, S., Munir, M., & Chen, J-L. (2015). Induction of innate immunity and its perturbation by influenza viruses. Protein and Cell, 6(10), 712-721. https://doi.org/10.1007/s13238-015-0191-z

Vancouver

Goraya MU, Wang S, Munir M, Chen J-L. Induction of innate immunity and its perturbation by influenza viruses. Protein and Cell. 2015 Oct;6(10):712-721. Epub 2015 Jul 24. doi: 10.1007/s13238-015-0191-z

Author

Goraya, Mohsan Ullah ; Wang, Song ; Munir, Muhammad et al. / Induction of innate immunity and its perturbation by influenza viruses. In: Protein and Cell. 2015 ; Vol. 6, No. 10. pp. 712-721.

Bibtex

@article{1d429bed9b73422a8614c7f35e289803,
title = "Induction of innate immunity and its perturbation by influenza viruses",
abstract = "Influenza A viruses (IAV) are highly contagious pathogens causing dreadful losses to human and animal, around the globe. IAVs first interact with the host through epithelial cells, and the viral RNA containing a 5'-triphosphate group is thought to be the critical trigger for activation of effective innate immunity via pattern recognition receptors-dependent signaling pathways. These induced immune responses establish the antiviral state of the host for effective suppression of viral replication and enhancing viral clearance. However, IAVs have evolved a variety of mechanisms by which they can invade host cells, circumvent the host immune responses, and use the machineries of host cells to synthesize and transport their own components, which help them to establish a successful infection and replication. In this review, we will highlight the molecular mechanisms of how IAV infection stimulates the host innate immune system and strategies by which IAV evades host responses.",
keywords = "Animals, Humans, Immune Evasion, Immunity, Innate, Influenza A virus, Influenza, Human, Receptors, Pattern Recognition, Virus Attachment, Journal Article, Research Support, Non-U.S. Gov't, Review",
author = "Goraya, {Mohsan Ullah} and Song Wang and Muhammad Munir and Ji-Long Chen",
year = "2015",
month = oct,
doi = "10.1007/s13238-015-0191-z",
language = "English",
volume = "6",
pages = "712--721",
journal = "Protein and Cell",
issn = "1674-800X",
publisher = "SpringerOpen",
number = "10",

}

RIS

TY - JOUR

T1 - Induction of innate immunity and its perturbation by influenza viruses

AU - Goraya, Mohsan Ullah

AU - Wang, Song

AU - Munir, Muhammad

AU - Chen, Ji-Long

PY - 2015/10

Y1 - 2015/10

N2 - Influenza A viruses (IAV) are highly contagious pathogens causing dreadful losses to human and animal, around the globe. IAVs first interact with the host through epithelial cells, and the viral RNA containing a 5'-triphosphate group is thought to be the critical trigger for activation of effective innate immunity via pattern recognition receptors-dependent signaling pathways. These induced immune responses establish the antiviral state of the host for effective suppression of viral replication and enhancing viral clearance. However, IAVs have evolved a variety of mechanisms by which they can invade host cells, circumvent the host immune responses, and use the machineries of host cells to synthesize and transport their own components, which help them to establish a successful infection and replication. In this review, we will highlight the molecular mechanisms of how IAV infection stimulates the host innate immune system and strategies by which IAV evades host responses.

AB - Influenza A viruses (IAV) are highly contagious pathogens causing dreadful losses to human and animal, around the globe. IAVs first interact with the host through epithelial cells, and the viral RNA containing a 5'-triphosphate group is thought to be the critical trigger for activation of effective innate immunity via pattern recognition receptors-dependent signaling pathways. These induced immune responses establish the antiviral state of the host for effective suppression of viral replication and enhancing viral clearance. However, IAVs have evolved a variety of mechanisms by which they can invade host cells, circumvent the host immune responses, and use the machineries of host cells to synthesize and transport their own components, which help them to establish a successful infection and replication. In this review, we will highlight the molecular mechanisms of how IAV infection stimulates the host innate immune system and strategies by which IAV evades host responses.

KW - Animals

KW - Humans

KW - Immune Evasion

KW - Immunity, Innate

KW - Influenza A virus

KW - Influenza, Human

KW - Receptors, Pattern Recognition

KW - Virus Attachment

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1007/s13238-015-0191-z

DO - 10.1007/s13238-015-0191-z

M3 - Journal article

C2 - 26206138

VL - 6

SP - 712

EP - 721

JO - Protein and Cell

JF - Protein and Cell

SN - 1674-800X

IS - 10

ER -