Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Joint modelling of longitudinal measurements and event time data.
AU - Henderson, Robin
AU - Diggle, Peter J.
AU - Dobson, Angela
PY - 2000/12
Y1 - 2000/12
N2 - This paper formulates a class of models for the joint behaviour of a sequence of longitudinal measurements and an associated sequence of event times, including single-event survival data. This class includes and extends a number of specific models which have been proposed recently, and, in the absence of association, reduces to separate models for the measurements and events based, respectively, on a normal linear model with correlated errors and a semi-parametric proportional hazards or intensity model with frailty. Special cases of the model class are discussed in detail and an estimation procedure which allows the two components to be linked through a latent stochastic process is described. Methods are illustrated using results from a clinical trial into the treatment of schizophrenia.
AB - This paper formulates a class of models for the joint behaviour of a sequence of longitudinal measurements and an associated sequence of event times, including single-event survival data. This class includes and extends a number of specific models which have been proposed recently, and, in the absence of association, reduces to separate models for the measurements and events based, respectively, on a normal linear model with correlated errors and a semi-parametric proportional hazards or intensity model with frailty. Special cases of the model class are discussed in detail and an estimation procedure which allows the two components to be linked through a latent stochastic process is described. Methods are illustrated using results from a clinical trial into the treatment of schizophrenia.
KW - Biomarkers
KW - Counting processes
KW - Informative drop-out
KW - Repeated measurements
KW - Serial correlation
KW - Survival
U2 - 10.1093/biostatistics/1.4.465
DO - 10.1093/biostatistics/1.4.465
M3 - Journal article
VL - 1
SP - 465
EP - 480
JO - Biostatistics
JF - Biostatistics
SN - 1468-4357
IS - 4
ER -